{"id":12512,"date":"2025-08-20T22:35:07","date_gmt":"2025-08-20T22:35:07","guid":{"rendered":"https:\/\/www.europesays.com\/ie\/12512\/"},"modified":"2025-08-20T22:35:07","modified_gmt":"2025-08-20T22:35:07","slug":"inappropriate-prescribing-tied-to-mortality-risk-in-seniors","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/ie\/12512\/","title":{"rendered":"Inappropriate Prescribing Tied to Mortality Risk in Seniors"},"content":{"rendered":"<p><strong>TOPLINE:<\/strong><\/p>\n<p>Older adults who were prescribed medications flagged as potentially inappropriate had an increased risk for mortality, with more than 80% exposed to potentially inappropriate prescribing. Potential prescribing omissions of indicated medications were also linked to increased mortality risk.<\/p>\n<p><strong>METHODOLOGY:<\/strong><\/p>\n<ul>\n<li>Researchers assessed potentially inappropriate prescribing and its link to long-term mortality in 1210 community-dwelling older adults (mean age, 72.9 years; 53% women) from a community-based longitudinal study in Israel, using data collected from 1999 to 2007.<\/li>\n<li>Participants were asked to bring their regular medications and a summary letter from their treating physician, with medication information documented on a form.<\/li>\n<li>Potentially inappropriate medications were identified from the 2023 American Geriatrics Society Beers Criteria and the European Screening Tool of Older Persons\u2019 Prescription (STOPP) version 3; potential prescribing omissions were identified using the Screening Tool to Alert doctors to Right Treatment version 3 criteria.<\/li>\n<li>Outcomes included all-cause mortality and noncancer mortality, identified using diagnostic codes. The median follow-up duration was 13 years.<\/li>\n<\/ul>\n<p><strong>TAKEAWAY:<\/strong><\/p>\n<ul>\n<li>On the basis of at least one criterion, 81.2% of participants took a drug listed as potentially inappropriate, and 37.9% were exposed to potentially inappropriate medications and omissions.<\/li>\n<li>Exposure to two or more potentially inappropriate medications using the Beers criteria was associated with an increased risk for all-cause mortality (adjusted hazard ratio [aHR], 1.31; 95% CI, 1.04-1.64).<\/li>\n<li>Exposure to two or more potentially inappropriate medications was linked to an increase in the risk for noncancer mortality (Beers criteria: aHR, 1.40; 95% CI, 1.09-1.80; STOPP criteria: aHR, 1.42; 95% CI, 1.12-1.81).<\/li>\n<li>Exposure to two or more potential prescribing omissions was linked to an increase in the risk for all-cause mortality (aHR, 1.84; 95% CI, 1.24-2.72) and for noncancer mortality (aHR, 2.00; 95% CI, 1.27-3.13), with stronger associations observed in men (P for interaction = .012).<\/li>\n<\/ul>\n<p><strong>IN PRACTICE:<\/strong><\/p>\n<p>\u201cBoth over-prescribing risky medications and under-prescribing necessary ones significantly increase mortality risk in the aging population, demonstrating the need for regular medication reviews even in healthy older adults,\u201d the authors of the study wrote.<\/p>\n<p><strong>SOURCE:<\/strong><\/p>\n<p>This study was led by Liat Orenstein of the Gertner Institute for Epidemiology and Health Policy Research at the Sheba Medical Center in Ramat-Gan, Israel. It was published <a href=\"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/jgs.70002\" rel=\"nofollow noopener\" target=\"_blank\">online on<\/a> August 11, 2025, in the Journal of the American Geriatrics Society.<\/p>\n<p><strong>LIMITATIONS:<\/strong><\/p>\n<p>The hazard associated with prescribing omissions declined over time, suggesting a need for further investigation into time-dependent effects. Only survivors who agreed to participate were included, which may have introduced survival bias; therefore, the findings may mainly apply to healthier older adults living in the community.<\/p>\n<p><strong>DISCLOSURES:<\/strong><\/p>\n<p>This study was supported by Tel-Aviv University through the Albert and Alba Cuenca Institute for Therapeutical-Approaches to Age Related Diseases. The authors declared having no conflicts of interest.<\/p>\n<p>This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.<\/p>\n","protected":false},"excerpt":{"rendered":"TOPLINE: Older adults who were prescribed medications flagged as potentially inappropriate had an increased risk for mortality, with&hellip;\n","protected":false},"author":2,"featured_media":12513,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[274],"tags":[291,289,7882,612,18,8851,5321,3026,1015,11563,8852,8850,135,5455,19,17,610,462,7881,7880,2835,8853,5196],"class_list":{"0":"post-12512","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-medication","8":"tag-ai","9":"tag-artificial-intelligence","10":"tag-artificial-neural-networks","11":"tag-deep-learning","12":"tag-eire","13":"tag-elder-care","14":"tag-elderly","15":"tag-epidemiology","16":"tag-europe","17":"tag-european","18":"tag-geriatric-medicine","19":"tag-geriatrics","20":"tag-health","21":"tag-health-policy","22":"tag-ie","23":"tag-ireland","24":"tag-machine-learning","25":"tag-medication","26":"tag-ml-natural-language-processing","27":"tag-npl","28":"tag-older-adults","29":"tag-senior-citizens","30":"tag-seniors"},"share_on_mastodon":{"url":"","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts\/12512","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/comments?post=12512"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts\/12512\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/media\/12513"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/media?parent=12512"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/categories?post=12512"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/tags?post=12512"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}