{"id":175200,"date":"2025-11-11T16:08:13","date_gmt":"2025-11-11T16:08:13","guid":{"rendered":"https:\/\/www.europesays.com\/ie\/175200\/"},"modified":"2025-11-11T16:08:13","modified_gmt":"2025-11-11T16:08:13","slug":"cyclophilins-as-key-players-in-protozoan-parasite-infections-parasites-vectors","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/ie\/175200\/","title":{"rendered":"Cyclophilins as key players in protozoan parasite infections | Parasites & Vectors"},"content":{"rendered":"
  • \n

    Barik S. Immunophilins: for the love of proteins. Cell Mol Life Sci. 2006;63:2889\u2013900.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Wang P, Heitman J. The cyclophilins. Genome Biol. 2005;6:226.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Galat A. Peptidylprolyl cis\/trans isomerases (immunophilins): biological diversity-targets-functions. Curr Top Med Chem. 2003;3:1315\u201347.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Tuccinardi T, Rizzolio F. Peptidyl-prolyl isomerases in human pathologies. Front Pharmacol. 2019;10:794.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Favretto F, Jim\u00e9nez-Faraco E, Conter C, Dominici P, Hermoso JA, Astegno A. Structural basis for cyclosporin isoform-specific inhibition of cyclophilins from Toxoplasma gondii. ACS Infect Dis. 2023;9:365\u201377.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Wu Y, Ma Z, Zhang Y, Zhang M, Shi X, Zhang M, et\u00a0al. The role of cyclophilins in viral infection and the immune response. J Infect. 2022;85:365\u201373.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Kalinina A, Grigorieva E, Smirnova A, Kazansky D, Khromykh L. Pharmacokinetic parameters of recombinant human cyclophilin A in mice. Eur J Drug Metab Pharmacokinet. 2024;49:57\u201369.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Lin D-T, Lechleiter JD. Mitochondrial targeted cyclophilin D protects cells from cell death by peptidyl prolyl isomerization. J Biol Chem. 2002;277:31134\u201341.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Harding MW. Immunophilins, mTOR, and pharmacodynamic strategies for a targeted cancer therapy: commentary re: JM Peralba et\u00a0al., pharmacodynamic evaluation of CCI-779, an inhibitor of mTOR, in cancer patients. Clin. Cancer Res., 9:2887\u20132892, 2003. Clin Cancer Res. 2003;9:2882\u20136.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Liang L, Lin R, Xie Y, Lin H, Shao F, Rui W, et\u00a0al. The role of cyclophilins in inflammatory bowel disease and colorectal cancer. Int J Biol Sci. 2021;17:2548\u201360.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Tajti G, Gebetsberger L, Pamlitschka G, Aigner-Radakovics K, Leitner J, Steinberger P, et\u00a0al. Cyclophilin\u2013CD147 interaction enables SARS-CoV-2 infection of human monocytes and their activation via Toll-like receptors 7 and 8. Front Immunol. 2025;16:1460089.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Wang J-j, Chen C, Xie P-f, Pan Y, Tan Y-h, Tang L-j. Proteomic analysis and immune properties of exosomes released by macrophages infected with Mycobacterium avium. Microbes Infect. 2014;16:283\u201391.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Szempruch AJ, Dennison L, Kieft R, Harrington JM, Hajduk SL. Sending a message: extracellular vesicles of pathogenic protozoan parasites. Nat Rev Microbiol. 2016;14:669\u201375.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Sharma AK, Mal S, Sahu SK, Bagchi S, Majumder D, Chakravorty D, et\u00a0al. Mycobacterial peptidyl prolyl isomerase A activates STING-TBK1-IRF3 signaling to promote IFN\u03b2 release in macrophages. FEBS J. 2025;292:94\u2013114.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Zhao X, Zhao X, Di W, Wang C. Inhibitors of cyclophilin A: current and anticipated pharmaceutical agents for inflammatory diseases and cancers. Molecules. 2024;29:1235.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Wang T, Becker D, Twizerimana AP, Luedde T, Gohlke H, M\u00fcnk C. Cyclophilin a regulates tripartite motif 5 alpha restriction of HIV-1. Int J Mol Sci. 2025;26:495.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Molle J, Duponchel S, Rieusset J, Ovize M, Ivanov AV, Zoulim F, et\u00a0al. Exploration of the role of cyclophilins in established hepatitis B and C infections. Viruses. 2024;17:11.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Liao Y, Luo D, Peng K, Zeng Y. Cyclophilin A: a key player for etiological agent infection. Appl Microbiol Biotechnol. 2021;105:1365\u201377.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Xu M, Zhang X, Yu Q, Zhao Q, Li J, Gong P, et\u00a0al. Characterization of cyclophilin 23 as a novel factor for development and pathogenicity of Cryptosporidium parvum. Vet Parasitol. 2025. https:\/\/doi.org\/10.1016\/j.vetpar.2025.110539<\/a>.<\/p>\n

    Article<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Kameyama K, Nishimura M, Punsantsogvoo M, Ibrahim HM, Xuan X, Furuoka H, et\u00a0al. Immunological characterization of Neospora caninum cyclophilin. Parasitology. 2012;139:294\u2013301.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Tuo W, Fetterer R, Jenkins M, Dubey J. Identification and characterization of Neospora caninum cyclophilin that elicits gamma interferon production. Infect Immun. 2005;73:5093\u2013100.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Acharya S, Da\u2019dara AA, Skelly PJ. Schistosome immunomodulators. PLoS Pathog. 2021;17:e1010064.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Kulkarni MM, Karafova A, Kamysz W, Schenkman S, Pelle R, McGwire BS. Secreted trypanosome cyclophilin inactivates lytic insect defense peptides and induces parasite calcineurin activation and infectivity. J Biol Chem. 2013;288:8772\u201384.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Aranda-Chan V, C\u00e1rdenas-Guerra RE, Otero-Pedraza A, Pacindo-Cabrales EE, Flores-Pucheta CI, Montes-Flores O, et\u00a0al. Insights into peptidyl-prolyl cis-trans isomerases from clinically important protozoans: from structure to potential biotechnological applications. Pathogens. 2024;13:644.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Bruchhaus I, Roeder T, Lotter H, Schwerdtfeger M, Tannich E. Differential gene expression in Entamoeba histolytica isolated from amoebic liver abscess. Mol Microbiol. 2002;44:1063\u201372.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Carrero JC, Petrossian P, Olivos A, S\u00e1nchez-Zerpa Ma, Ostoa-Soloma P, Laclette JP. Effect of cyclosporine A on Entamoeba histolytica. Arch Med Res. 2000;31:S8-9.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Naiyer S, Bhattacharya A, Bhattacharya S. Advances in Entamoeba histolytica biology through transcriptomic analysis. Front Microbiol. 2019;10:1921.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Yu H-S, Kong H-H, Chung D-I. Cloning and characterization of Giardia intestinalis cyclophilin. Korean J Parasitol. 2002;40:131\u20138.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Hosse RJ, Kr\u00fccken J, Bierbaum S, Greif G, Wunderlich F. Eimeria tenella: genomic organization and expression of an 89 kDa cyclophilin. Exp Parasitol. 2008;118:275\u20139.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Perkins ME, Wu TW, Le Blancq SM. Cyclosporin analogs inhibit in vitro growth of Cryptosporidium parvum. Antimicrob Agents Chemother. 1998;42:843\u20138.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Martin T, Lou Y-C, Chou C-C, Wei S-Y, Sadotra S, Cho C-C, et\u00a0al. Structural basis of interaction between dimeric cyclophilin 1 and Myb1 transcription factor in Trichomonas vaginalis. Sci Rep. 2018;8:5410.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Chu CH, Huang YH, Liu HW, Hsu HM, Tai JH. Membrane localization of a Myb3 transcription factor regulated by a TvCyP1 cyclophilin in the parasitic protozoan Trichomonas vaginalis. FEBS J. 2018;285:929\u201346.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Hsu H-M, Huang Y-H, Aryal S, Liu H-W, Chen C, Chen S-H, et\u00a0al. Endomembrane protein trafficking regulated by a Tv CyP2 cyclophilin in the protozoan parasite, Trichomonas vaginalis. Sci Rep. 2020;10:1275.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Yau W-L, Blisnick T, Taly J-F, Helmer-Citterich M, Schiene-Fischer C, Leclercq O, et\u00a0al. Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viability. PLoS Negl Trop Dis. 2010;4:e729.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Yau WL, Lambertz U, Colineau L, Pescher P, MacDonald A, Zander D, et\u00a0al. Phenotypic characterization of a Leishmania donovani cyclophilin 40 null mutant. J Eukaryot Microbiol. 2016;63:823\u201333.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Perrone AE, Milduberger N, Fuchs AG, Bustos PL, Bua J. A functional analysis of the cyclophilin repertoire in the protozoan parasite Trypanosoma cruzi. Biomolecules. 2018;8:132.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Zheng Z-W, Li J, Chen H, He J-L, Chen Q-W, Zhang J-H, et\u00a0al. Evaluation of in vitro antileishmanial efficacy of cyclosporin A and its non-immunosuppressive derivative, dihydrocyclosporin A. Parasit Vectors. 2020;13:132.<\/p>\n


    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Rascher C, Pahl A, Pecht A, Brune K, Solbach W, Bang H. Leishmania major parasites express cyclophilin isoforms with an unusual interaction with calcineurin. Biochem J. 1998;334:659\u201367.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Jha B, Varikuti S, Bishop N, dos Santos G, McDonald J, Sur A, et al. An effective live vaccine strain of trypanosoma cruzi prevents chagas disease in the mouse model. https:\/\/www.researchgate.net\/publication\/346274839_An_Effective_Live_Vaccine_Strain_Of_Trypanosoma_Cruzi_Prevents_Chagas_Disease_In_The_Mouse_Model<\/a>. 2020. Accessed Oct 2020.<\/p>\n<\/li>\n

  • \n

    Bua J, Fichera L, Fuchs A, Potenza M, Dubin M, Wenger R, et\u00a0al. Anti-Trypanosoma cruzi effects of cyclosporin A derivatives: possible role of a P-glycoprotein and parasite cyclophilins. Parasitology. 2008;135:217\u201328.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Ibrahim HM, Nishimura M, Tanaka S, Awadin W, Furuoka H, Xuan X, et\u00a0al. Overproduction of Toxoplasma gondii cyclophilin-18 regulates host cell migration and enhances parasite dissemination in a CCR5-independent manner. BMC Microbiol. 2014;14:76.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Favretto F, Jim\u00e9nez-Faraco E, Catucci G, Di Matteo A, Travaglini-Allocatelli C, Sadeghi SJ, et\u00a0al. Evaluating the potential of non-immunosuppressive cyclosporin analogs for targeting Toxoplasma gondii cyclophilin: insights from structural studies. Protein Sci. 2024;33:e5157.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Adams B, Musiyenko A, Kumar R, Barik S. A novel class of dual-family immunophilins. J Biol Chem. 2005;280:24308\u201314.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    High K, Joiner K, Handschumacher R. Isolation, cDNA sequences, and biochemical characterization of the major cyclosporin-binding proteins of Toxoplasma gondii. J Biol Chem. 1994;269:9105\u201312.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Mineo TWP, Oliveira CJF, Silva DAO, Oliveira LL, Abatepaulo AR, Ribeiro DP, et\u00a0al. Neospora caninum excreted\/secreted antigens trigger CC-chemokine receptor 5-dependent cell migration. Int J Parasitol. 2010;40:797\u2013805.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Berriman M, Fairlamb AH. Detailed characterization of a cyclophilin from the human malaria parasite Plasmodium falciparum. Biochem J. 1998;334:437\u201345.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Bianchin A, Chubb AJ, Bell A. Immunophilins as possible drug targets in apicomplexan parasites. Compr Anal Parasite Biol: Metab Drug Discov: Metab Drug Discov. 2016. https:\/\/doi.org\/10.1002\/9783527694082.ch8<\/a>.<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Leneghan D, Bell A. Immunophilin\u2013protein interactions in Plasmodium falciparum. Parasitology. 2015;142:1404\u201314.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Zhao S, Liu J, Guan G, Liu A, Li Y, Yin H, et\u00a0al. Theileria annulata Cyclophilin1 (TaCyp1) interacts with host cell MED21. Front Microbiol. 2018;9:2973.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Mar\u00edn-Men\u00e9ndez A, Bell A. Overexpression, purification and assessment of cyclosporin binding of a family of cyclophilins and cyclophilin-like proteins of the human malarial parasite Plasmodium falciparum. Protein Expr Purif. 2011;78:225\u201334.<\/p>\n

    PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Mar\u00edn-Men\u00e9ndez A, Monaghan P, Bell A. A family of cyclophilin-like molecular chaperones in Plasmodium falciparum. Mol Biochem Parasitol. 2012;184:44\u20137.<\/p>\n

    PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Bell A, Monaghan P, Page AP. Peptidyl-prolyl cis\u2013trans isomerases (immunophilins) and their roles in parasite biochemistry, host\u2013parasite interaction and antiparasitic drug action. Int J Parasitol. 2006;36:261\u201376.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Acharya P, Kumar R, Tatu U. Chaperoning a cellular upheaval in malaria: heat shock proteins in Plasmodium falciparum. Mol Biochem Parasitol. 2007;153:85\u201394.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Kr\u00fccken J, Greif G, von Samson-Himmelstjerna G. In silico analysis of the cyclophilin repertoire of apicomplexan parasites. Parasit Vectors. 2009;2:27.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Mok S, Ashley EA, Ferreira PE, Zhu L, Lin Z, Yeo T, et\u00a0al. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance. Science. 2015;347:431\u20135.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Vance N. Quantification of Plasmodium falciparum Cyclophilin 19B transcripts via qPCR in normal and sickle-trait hemoglobin genotypes. Durham: Duke University; 2021.<\/p>\n


    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Ibrahim HM, Bannai H, Xuan X, Nishikawa Y. Toxoplasma gondii cyclophilin 18-mediated production of nitric oxide induces bradyzoite conversion in a CCR5-dependent manner. Infect Immun. 2009;77:3686\u201395.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Ibrahim HM, Xuan X, Nishikawa Y. Toxoplasma gondii cyclophilin 18 regulates the proliferation and migration of murine macrophages and spleen cells. Clin Vaccine Immunol. 2010;17:1322\u20139.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Aliberti J, Valenzuela JG, Carruthers VB, Hieny S, Andersen J, Charest H, et\u00a0al. Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells. Nat Immunol. 2003;4:485\u201390.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Del Rio L, Butcher BA, Bennouna S, Hieny S, Sher A, Denkers EY. Toxoplasma gondii triggers myeloid differentiation factor 88-dependent IL-12 and chemokine ligand 2 (monocyte chemoattractant protein 1) responses using distinct parasite molecules and host receptors. J Immunol. 2004;172:6954\u201360.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Denkers EY. From cells to signaling cascades: manipulation of innate immunity by Toxoplasma gondii. FEMS Immunol Med Microbiol. 2003;39:193\u2013203.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Golding H, Aliberti J, King LR, Manischewitz J, Andersen J, Valenzuela J, et\u00a0al. Inhibition of HIV-1 infection by a CCR5-binding cyclophilin from Toxoplasma gondii. Blood. 2003;102:3280\u20136.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Sassi A, Brichacek B, Hieny S, Yarovinsky F, Golding H, Grivel J-C, et\u00a0al. Toxoplasma gondii inhibits R5 HIV-1 replication in human lymphoid tissues ex vivo. Microbes Infect. 2009;11:1106\u201313.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Carey KL, Donahue CG, Ward GE. Identification and molecular characterization of GRA8, a novel, proline-rich, dense granule protein of Toxoplasma gondii. Mol Biochem Parasitol. 2000;105:25\u201337.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Ying Z, Wu Y, Sun Z, Liu J, Liu Q. The cyclophilin D (CypD) of Toxoplasma gondii is involved in the parasite\u2019s response to oxidative stress damage. Parasitol Res. 2024;123:1\u201313.<\/p>\n


    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Dos Santos GP, Abukawa FM, Souza-Melo N, Alc\u00e2ntara LM, Bittencourt-Cunha P, Moraes CB, et\u00a0al. Cyclophilin 19 secreted in the host cell cytosol by Trypanosoma cruzi promotes ROS production required for parasite growth. Cell Microbiol. 2021;23:e13295.<\/p>\n

    PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    R\u00eago JV, Duarte AP, Liarte DB, de Carvalho SF, Barreto HM, Bua J, et\u00a0al. Molecular characterization of cyclophilin (TcCyP19) in Trypanosoma cruzi populations susceptible and resistant to benznidazole. Exp Parasitol. 2015;148:73\u201380.<\/p>\n

    PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Perrone AE, Pinillo M, Rial MS, Fern\u00e1ndez M, Milduberger N, Gonz\u00e1lez C, et\u00a0al. Trypanosoma cruzi secreted cyclophilin Tc CyP19 as an early marker for trypanocidal treatment efficiency. Int J Mol Sci. 2023;24:11875.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Estrada D, Specker G, Mart\u00ednez A, Dias PP, Hissa B, Andrade LO, et\u00a0al. Cardiomyocyte diffusible redox mediators control Trypanosoma cruzi infection: role of parasite mitochondrial iron superoxide dismutase. Biochem J. 2018;475:1235\u201351.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Jha BK, Varikuti S, Verma C, Shivahare R, Bishop N, Dos Santos GP, et\u00a0al. Immunization with a Trypanosoma cruzi cyclophilin-19 deletion mutant protects against acute Chagas disease in mice. NPJ Vaccines. 2023;8:63.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Rassi JA, Marin JA, Rassi A. Chronic Chagas cardiomyopathy: a review of the main pathogenic mechanisms and the efficacy of aetiological treatment following the BENznidazole Evaluation for Interrupting Trypanosomiasis (BENEFIT) trial. Mem Inst Oswaldo Cruz. 2017;112:224\u201335.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Bakhtiyari M, Haji Aghasi A, Banihashemi S, Abbassioun A, Tavakol C, Zalpoor H. CD147 and cyclophilin a: a promising potential targeted therapy for COVID-19 and associated cancer progression and chemo-resistance. Infect Agents Cancer. 2023;18:20.<\/p>\n

    CAS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Roy S, Basu S, Datta AK, Bhattacharyya D, Banerjee R, Dasgupta D. Equilibrium unfolding of cyclophilin from Leishmania donovani: characterization of intermediate states. Int J Biol Macromol. 2014;69:353\u201360.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Venugopal V, Datta AK, Bhattacharyya D, Dasgupta D, Banerjee R. Structure of cyclophilin from Leishmania donovani bound to cyclosporin at 2.6 \u00c5 resolution: correlation between structure and thermodynamic data. Acta Crystallogr D Biol Crystallogr. 2009;65:1187\u201395.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Agallou M, Athanasiou E, Samiotaki M, Panayotou G, Karagouni E. Identification of immunoreactive Leishmania infantum protein antigens to asymptomatic dog sera through combined immunoproteomics and bioinformatics analysis. PLoS ONE. 2016;11:e0149894.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Yurchenko V, Xue Z, Sherry B, Bukrinsky M. Functional analysis of Leishmania major cyclophilin. Int J Parasitol. 2008;38:633\u20139.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Venugopal V, Sen B, Datta AK, Banerjee R. Structure of cyclophilin from Leishmania donovani at 1.97 \u00c5 resolution. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007;63:60\u20134.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Yurchenko V, Constant S, Eisenmesser E, Bukrinsky M. Cyclophilin\u2013CD147 interactions: a new target for anti-inflammatory therapeutics. Clin Exp Immunol. 2010;160:305\u201317.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Afrin F, Khan I, Hemeg HA. Leishmania-host interactions\u2014An epigenetic paradigm. Front Immunol. 2019;10:492.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Sen B, Venugopal V, Chakraborty A, Datta R, Dolai S, Banerjee R, et\u00a0al. Amino acid residues of Leishmania donovani cyclophilin key to interaction with its adenosine kinase: biological implications. Biochemistry. 2007;46:7832\u201343.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Dhanda AS, Lulic KT, Vogl AW, Mc Gee MM, Chiu RH, Guttman JA. Listeria membrane protrusion collapse: requirement of cyclophilin A for Listeria cell-to-cell spreading. J Infect Dis. 2019;219:145\u201353.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Dhanda AS, Warren KE, Chiu RH, Guttman JA. Cyclophilin A controls Salmonella internalization levels and is present at E. coli actin-rich pedestals. Anat Rec. 2018;301:2086\u201394.<\/p>\n

    CAS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Dimou M, Venieraki A, Katinakis P. Microbial cyclophilins: specialized functions in virulence and beyond. World J Microbiol Biotechnol. 2017;33:164.<\/p>\n

    PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Floudas A, Cluxton CD, Fahel J, Khan AR, Saunders SP, Amu S, et\u00a0al. Composition of the Schistosoma mansoni worm secretome: identification of immune modulatory cyclophilin A. PLoS Negl Trop Dis. 2017;11:e0006012.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Li J, Zhuang W, Cong L, Shi W, Cai X, Huang F, et\u00a0al. Cyclophilin A from Schistosoma japonicum promotes a Th2 response in mice. Parasit Vectors. 2013;6:330.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Marin-Menendez A, Bell A. Identification and characterization of novel Plasmodium falciparum cyclophilins and their roles in the antimalarial actions of cyclosporin A and derivatives. Malar J. 2010;9:O3.<\/p>\n

    PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Allman WR, Dey R, Liu L, Siddiqui S, Coleman AS, Bhattacharya P, et\u00a0al. TACI deficiency leads to alternatively activated macrophage phenotype and susceptibility to Leishmania infection. Proc Natl Acad Sci U S A. 2015;112:E4094\u2013103.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Yun C, Lillehoj H, Lillehoj E. Intestinal immune responses to coccidiosis. Dev Comp Immunol. 2000;24:303\u201324.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Maeda H, Boldbaatar D, Kusakisako K, Galay RL, Aung KM, Umemiya-Shirafuji R, et\u00a0al. Inhibitory effect of cyclophilin A from the hard tick Haemaphysalis longicornis on the growth of Babesia bovis and Babesia bigemina. Parasitol Res. 2013;112:2207\u201313.<\/p>\n

    PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Milduberger N, Bustos PL, Gonz\u00e1lez C, Perrone AE, Postan M, Bua J. Trypanosoma cruzi infection in cyclophilin D deficient mice. Exp Parasitol. 2021;220:108044.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Hoerauf A, Rascher C, Bang R, Pahl A, Solbach W, Brune K, et\u00a0al. Host-cell cyclophilin is important for the intracellular replication of Leishmania major. Mol Microbiol. 1997;24:421\u20139.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Nigro P, Pompilio G, Capogrossi M. Cyclophilin A: a key player for human disease. Cell Death Dis. 2013;4:e888.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Luban J, Bossolt KL, Franke EK, Kalpana GV, Goff SP. Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B. Cell. 1993;73:1067\u201378.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Bukrinsky MI. Cyclophilins: unexpected messengers in intercellular communications. Trends Immunol. 2002;23:323\u20135.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Thakur A, Mikkelsen H, Jungersen G. Intracellular pathogens: host immunity and microbial persistence strategies. J Immunol Res. 2019;2019:1356540.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Schor S, Einav S. Combating intracellular pathogens with repurposed host-targeted drugs. ACS Infect Dis. 2018;4:88\u201392.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Jin S, Zhang M, Qiao X. Cyclophilin A: promising target in cancer therapy. Cancer Biol Ther. 2024;25:2425127.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Williams PD, Owens CR, Dziegielewski J, Moskaluk CA, Read PW, Larner JM, et\u00a0al. Cyclophilin B expression is associated with in vitro radioresistance and clinical outcome after radiotherapy. Neoplasia. 2011;13:1122\u201331.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Motawea KR, Elhalag RH, Rouzan SS, Talat NE, Reyad SM, Ch\u00e9bl P, et\u00a0al. Cyclophilin c as a novel diagnostic and prognostic biomarker of coronary artery diseases. a systematic review and meta-analysis. Curr Probl Cardiol. 2023;48:101812.<\/p>\n

    PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Yao Q, Li M, Yang H, Chai H, Fisher W, Chen C. Roles of cyclophilins in cancers and other organ systems. World J Surg. 2005;29:276\u201380.<\/p>\n

    PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Zhang L, Liu Y, Zhou R, He B, Wang W, Zhang B. Cyclophilin d: guardian or executioner for tumor cells? Front Oncol. 2022;12:939588.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Piao M, Lee SH, Li Y, Choi J-K, Yeo C-Y, Lee KY. Cyclophilin E (CypE) functions as a positive regulator in osteoblast differentiation by regulating the transcriptional activity of Runx2. Cells. 2023;12:2549.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Ure DR, Trepanier DJ, Mayo PR, Foster RT. Cyclophilin inhibition as a potential treatment for nonalcoholic steatohepatitis (NASH). Expert Opin Investig Drugs. 2020;29:163\u201378.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Rajan S, Yoon HS. Structural insights into plasmodium PPIases. Front Cell Infect Microbiol. 2022;12:931635.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Clipstone NA, Crabtree GR. Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature. 1992;357:695\u20137.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Jin L, Harrison SC. Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin. Proc Natl Acad Sci U S A. 2002;99:13522\u20136.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Stauffer WT, Goodman AZ, Gallay PA. Cyclophilin inhibition as a strategy for the treatment of human disease. Front Pharmacol. 2024;15:1417945.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Potenza M, Galat A, Minning T, Ruiz A, Duran R, Tarleton R, et\u00a0al. Analysis of the Trypanosoma cruzi cyclophilin gene family and identification of Cyclosporin A binding proteins. Parasitology. 2006;132:867\u201382.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Liu C, von Brunn A, Zhu D. Cyclophilin A and CD147: novel therapeutic targets for the treatment of COVID-19. Med Drug Discov. 2020;7:100056.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Gavigan CS, Kiely SP, Hirtzlin J, Bell A. Cyclosporin-binding proteins of Plasmodium falciparum. Int J Parasitol. 2003;33:987\u201396.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Kucharski M, Wirjanata G, Nayak S, Boentoro J, Dziekan JM, Assisi C, et\u00a0al. Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the malaria parasite Plasmodium falciparum. PLoS Pathog. 2023;19:e1011118.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Chaurasiya A, Kumari G, Garg S, Shoaib R, Anam Z, Joshi N, et\u00a0al. Targeting artemisinin-resistant malaria by repurposing the anti-hepatitis C virus drug alisporivir. Antimicrob Agents Chemother. 2022;66:e00392\u201322.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Prakash P, Zeeshan M, Saini E, Muneer A, Khurana S, Kumar Chourasia B, et\u00a0al. Human cyclophilin B forms part of a multi-protein complex during erythrocyte invasion by Plasmodium falciparum. Nat Commun. 2017;8:1548.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Satchwell TJ, Wright KE, Haydn-Smith KL, Sanchez-Roman Teran F, Moura PL, Hawksworth J, et\u00a0al. Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements. Nat Commun. 2019;10:3806.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Gavigan C, Shen M, Machado S, Bell A. Influence of the Plasmodium falciparum P-glycoprotein homologue 1 (pfmdr1 gene product) on the antimalarial action of cyclosporin. J Antimicrob Chemother. 2007;59:197\u2013203.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Reed MB, Saliba KJ, Caruana SR, Kirk K, Cowman AF. Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum. Nature. 2000;403:906\u20139.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Carraro R, B\u00faa J, Ruiz A, Paulino M. Modelling and study of cyclosporin A and related compounds in complexes with a Trypanosoma cruzi cyclophilin. J Mol Graph Model. 2007;26:48\u201361.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Morales MA, Watanabe R, Dacher M, Chafey P, Osorio y Fort\u00e9a J, Scott DA, et\u00a0al. Phosphoproteome dynamics reveal heat-shock protein complexes specific to the Leishmania donovani infectious stage. Proc Natl Acad Sci USA. 2010;107:8381\u20136.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Morales MA, Watanabe R, Laurent C, Lenormand P, Rousselle JC, Namane A, et\u00a0al. Phosphoproteomic analysis of Leishmania donovani pro-and amastigote stages. Proteomics. 2008;8:350\u201363.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Yau WaiLok YW, Pescher P, MacDonald A, Hem S, Zander D, Retzlaff S, et\u00a0al. The Leishmania donovani chaperone cyclophilin 40 is essential for intracellular infection independent of its stage-specific phosphorylation status. Mol Microbiol. 2014;93:80\u201397.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Santos-Gomes G, Rodrigues A, Teixeira F, Carreira J, Alexandre-Pires G, Carvalho S, et\u00a0al. Immunization with the Leishmania infantum recombinant cyclophilin protein 1 confers partial protection to subsequent parasite infection and generates specific memory T cells. Vaccine. 2014;32:1247\u201353.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Yu Q, Huang X, Gong P, Zhang Q, Li J, Zhang G, et\u00a0al. Protective immunity induced by a recombinant BCG vaccine encoding the cyclophilin gene of Toxoplasma gondii. Vaccine. 2013;31:6065\u201371.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Gong P, Huang X, Yu Q, Li Y, Huang J, Li J, et\u00a0al. The protective effect of a DNA vaccine encoding the Toxoplasma gondii cyclophilin gene in BALB\/c mice. Parasite Immunol. 2013;35:140\u20136.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Watanabe Costa R, da Silveira JF, Bahia D. Interactions between Trypanosoma cruzi secreted proteins and host cell signaling pathways. Front Microbiol. 2016;7:388.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Tuo W, Feng X, Cao L, Vinyard B, Dubey J, Fetterer R, et\u00a0al. Vaccination with Neospora caninum-cyclophilin and-profilin confers partial protection against experimental neosporosis-induced abortion in sheep. Vaccine. 2021;39:4534\u201344.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Fereig RM, Abdelbaky HH, Kuroda Y, Nishikawa Y. Critical role of TLR2 in triggering protective immunity with cyclophilin entrapped in oligomannose-coated liposomes against Neospora caninum infection in mice. Vaccine. 2019;37:937\u201344.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Liu J, Farmer JD, Lane WS, Friedman J, Weissman I, Schreiber SL. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 1991;66:807\u201315.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Singh B, Varikuti S, Halsey G, Volpedo G, Hamza OM, Satoskar AR. Host-directed therapies for parasitic diseases. Future Med Chem. 2019;11:1999\u20132018.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Su L-H, Lee GA, Huang Y-C, Chen Y-H, Sun C-H. Neomycin and puromycin affect gene expression in Giardia lamblia stable transfection. Mol Biochem Parasitol. 2007;156:124\u201335.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Chatellard-Gruaz D, Saurat J-H, Siegenthaler G. Differential expression of cyclophilin isoforms during keratinocyte differentiation. Biochem J. 1994;303:863\u20137.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Matrangolo FS, Liarte DB, Andrade LC, de Melo MF, Andrade JM, Ferreira RF, et\u00a0al. Comparative proteomic analysis of antimony-resistant and-susceptible Leishmania braziliensis and Leishmania infantum chagasi lines. Mol Biochem Parasitol. 2013;190:63\u201375.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Colebrook A, Jenkins D, Lightowlers M. Anti-parasitic effect of cyclosporin A on Echinococcus granulosus and characterization of the associated cyclophilin protein. Parasitology. 2002;125:485\u201393.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Ortona E, Vaccari S, Margutti P, Delunardo F, Rigano R, Profumo E, et\u00a0al. Immunological characterization of Echinococcus granulosus cyclophilin, an allergen reactive with IgE and IgG4 from patients with cystic echinococcosis. Clin Exp Immunol. 2002;128:124\u201330.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Rakshit R, Bahl A, Arunima A, Pandey S, Tripathi D. Beyond protein folding: the pleiotropic functions of PPIases in cellular processes and microbial virulence. Biochem Biophys Acta. 2025;1869:130754.<\/p>\n

    CAS<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Ma Z, Zhang W, Wu Y, Zhang M, Wang L, Wang Y, et\u00a0al. Cyclophilin A inhibits A549 cell oxidative stress and apoptosis by modulating the PI3K\/Akt\/mTOR signaling pathway. 2021. Biosci Rep. https:\/\/doi.org\/10.1042\/BSR20203219<\/a>.<\/p>\n<\/li>\n

  • \n

    Guo Y, Jiang M, Zhao X, Gu M, Wang Z, Xu S, et\u00a0al. Cyclophilin A promotes non-small cell lung cancer metastasis via p38 MAPK. Thorac Cancer. 2018;9:120\u20138.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Prieto JH, Fischer E, Koncarevic S, Yates J, Becker K. Large-scale differential proteome analysis in Plasmodium falciparum under drug treatment. In: Parasite Genomics Protocols. New York: Springer; 2015.<\/p>\n


    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Dousti M, Manzano-Rom\u00e1n R, Rashidi S, Barzegar G, Ahmadpour NB, Mohammadi A, et\u00a0al. A proteomic glimpse into the effect of antimalarial drugs on Plasmodium falciparum proteome towards highlighting possible therapeutic targets. Pathog Dis. 2021;79:ftaa071.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Lopes KF, Freire ML, Murta SMF, Oliveira E. Efficacy of vaccines based on chimeric or multiepitope antigens for protection against visceral leishmaniasis: a systematic review. PLoS Negl Trop Dis. 2024;18:e0012757.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Mortazavidehkordi N, Fallah A, Abdollahi A, Kia V, Khanahmad H, Najafabadi ZG, et\u00a0al. A lentiviral vaccine expressing KMP11-HASPB fusion protein increases immune response to Leishmania major in BALB\/C. Parasitol Res. 2018;117:2265\u201373.<\/p>\n

    PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Muruaga EJ, Briones G, Roset MS. Biochemical and functional characterization of Brucella abortus cyclophilins: so similar, yet so different. Front Microbiol. 2022;13:1046640.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n","protected":false},"excerpt":{"rendered":"Barik S. Immunophilins: for the love of proteins. Cell Mol Life Sci. 2006;63:2889\u2013900. CAS\u00a0 PubMed\u00a0 PubMed Central\u00a0 Google…\n","protected":false},"author":2,"featured_media":175201,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[77],"tags":[99770,18,10925,19,692,4381,17,4382,99771,133,99772,4384,94947,11794,7356],"class_list":{"0":"post-175200","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-science","8":"tag-cyclophilin","9":"tag-eire","10":"tag-entomology","11":"tag-ie","12":"tag-infection","13":"tag-infectious-diseases","14":"tag-ireland","15":"tag-parasitology","16":"tag-protozoan-parasite","17":"tag-science","18":"tag-therapeutic-target","19":"tag-tropical-medicine","20":"tag-vaccine-development","21":"tag-veterinary-medicine-veterinary-science","22":"tag-virology"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@ie\/115531937447274153","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts\/175200","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/comments?post=175200"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts\/175200\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/media\/175201"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/media?parent=175200"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/categories?post=175200"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/tags?post=175200"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}