{"id":188719,"date":"2025-11-19T09:38:08","date_gmt":"2025-11-19T09:38:08","guid":{"rendered":"https:\/\/www.europesays.com\/ie\/188719\/"},"modified":"2025-11-19T09:38:08","modified_gmt":"2025-11-19T09:38:08","slug":"the-effect-of-pulsatile-lavage-on-antibiotic-elution-from-bone-cements-in-two-stage-revision-for-periprosthetic-joint-infection-journal-of-orthopaedic-surgery-and-research","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/ie\/188719\/","title":{"rendered":"The effect of pulsatile lavage on antibiotic elution from bone cements in two-stage revision for periprosthetic joint infection | Journal of Orthopaedic Surgery and Research"},"content":{"rendered":"
  • \n

    James I, Huddleston I, MD. Annual Report 2024. American Academy of Orthopaedic Surgeons\u2014American Joint Replacement Registry. 11. https:\/\/www.aaos.org\/registries\/publications\/ajrr-annual-report\/<\/a> 2024:141.<\/p>\n<\/li>\n

  • \n

    Alrayes MM, Sukeik M. Two-stage revision in periprosthetic knee joint infections. World J Orthop. 2023;14(3):113\u201322.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Dombrowski ME, Wilson AE, Wawrose RA, O\u2019Malley MJ, Urish KL, Klatt BA. A low percentage of patients satisfy typical indications for single-stage exchange arthroplasty for chronic periprosthetic joint infection. Clin Orthop Relat Res. 2020;478(8):1780\u20136.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Lazic I, Scheele C, Pohlig F, von Eisenhart-Rothe R, Suren C. Treatment options in PJI\u2014Is two-stage still gold standard? J Orthop. 2021;23:180\u20134.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Rava A, Bruzzone M, Cottino U, Enrietti E, Rossi R. Hip spacers in two-stage revision for periprosthetic joint infection: a review of literature. Joints. 2019;7(2):56\u201363.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Knappe K, Bitsch RG, Schonhoff M, Walker T, Renkawitz T, Jaeger S. Pulsatile lavage systems with high impact pressure and high flow produce cleaner cancellous bone prior to cementation in cemented arthroplasty. J Clin Med. 2021. https:\/\/doi.org\/10.3390\/jcm11010088<\/a>.<\/p>\n

    Article<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Knappe K, Lunz A, Bulhoff M, Schonhoff M, Renkawitz T, Kretzer JP, et al. Pulsatile lavage systems and their potential to penetrate soft tissue. Eur J Trauma Emerg Surg. 2023;49(1):327\u201333.<\/p>\n

    PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Charette RS, Melnic CM. Two-stage revision arthroplasty for the treatment of prosthetic joint infection. Curr Rev Musculoskelet Med. 2018;11(3):332\u201340.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Vielgut I, Sadoghi P, Wolf M, et al. Two-stage revision of prosthetic hip joint infections using antibiotic-loaded cement spacers: when is the best time to perform the second stage? Int Orthop. 2015;39(9):1731\u20136.<\/p>\n

    PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Anagnostakos K, Kelm J. Enhancement of antibiotic elution from acrylic bone cement. J Biomed Mater Res B Appl Biomater. 2009;90(1):467\u201375.<\/p>\n

    PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Shahpari O, Mousavian A, Elahpour N, Malahias MA, Ebrahimzadeh MH, Moradi A. The use of antibiotic impregnated cement spacers in the treatment of infected total joint replacement: challenges and achievements. Arch Bone Jt Surg. 2020;8(1):11\u201320.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Lunz A, Schonhoff M, Omlor GW, et al. Enhanced antibiotic release from bone cement spacers utilizing dual antibiotic loading with elevated vancomycin concentrations in two-stage revision for periprosthetic joint infection. Int Orthop. 2023;47(11):2655\u201361.<\/p>\n

    PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Parra-Ruiz FJ, Gonzalez-Gomez A, Fernandez-Gutierrez M, et al. Development of advanced biantibiotic loaded bone cement spacers for arthroplasty associated infections. Int J Pharm. 2017;522(1\u20132):11\u201320.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Marczak D, Synder M, Sibinski M, Polguj M, Dudka J, Kowalczewski J. Two stage revision hip arthroplasty in periprosthetic joint infection. Comparison study: with or without the use of a spacer. Int Orthop. 2017;41(11):2253\u20138.<\/p>\n

    PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Lunz A, Omlor GW, Schmidt G, Moradi B, Lehner B, Streit MR. Quality of life, infection control, and complication rates using a novel custom-made articulating hip spacer during two-stage revision for periprosthetic joint infection. Arch Orthop Trauma Surg. 2022;142(12):4041\u201354.<\/p>\n

    PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Flesch I. Augmentation with antibiotic-impregnated spacers in sepsis revision surgery. Unfallchirurg. 2015;118(10):844\u201350.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Boelch SP, Rueckl K, Fuchs C, et al. Comparison of elution characteristics and compressive strength of biantibiotic-loaded PMMA Bone cement for spacers: copal(R) spacem with gentamicin and vancomycin versus palacos(R) R+G with vancomycin. Biomed Res Int. 2018;2018:4323518.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Kuhn KD, Renz N, Trampuz A. Local antibiotic therapy. Unfallchirurg. 2017;120(7):561\u201372.<\/p>\n

    PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Frew NM, Cannon T, Nichol T, Smith TJ, Stockley I. Comparison of the elution properties of commercially available gentamicin and bone cement containing vancomycin with \u2018home-made\u2019 preparations. Bone Joint J. 2017;99-B(1):73\u20137.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Bahrs C, Schnabel M, Frank T, Zapf C, Mutters R, von Garrel T. Lavage of contaminated surfaces: an in vitro evaluation of the effectiveness of different systems. J Surg Res. 2003;112(1):26\u201330.<\/p>\n

    PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Brown LL, Shelton HT, Bornside GH, Cohn I Jr. Evaluation of wound irrigation by pulsatile jet and conventional methods. Ann Surg. 1978;187(2):170\u20133.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Rodeheaver GT, Pettry D, Thacker JG, Edgerton MT, Edlich RF. Wound cleansing by high pressure irrigation. Surg Gynecol Obstet. 1975;141(3):357\u201362.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Ahn DK, Lee S, Moon SH, Kim DG, Hong SW, Shin WS. Bulb syringe and pulsed irrigation: which is more effective to remove bacteria in spine surgeries? Clin Spine Surg. 2016;29(1):34\u20137.<\/p>\n

    PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Gross A, Cutright DE, Bhaskar SN. Effectiveness of pulsating water jet lavage in treatment of contaminated crushed wounds. Am J Surg. 1972;124(3):373\u20137.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Svoboda SJ, Bice TG, Gooden HA, Brooks DE, Thomas DB, Wenke JC. Comparison of bulb syringe and pulsed lavage irrigation with use of a bioluminescent musculoskeletal wound model. J Bone Joint Surg Am. 2006;88(10):2167\u201374.<\/p>\n

    PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    HeraeusMedical. PALACOS\u00ae R+G \u2013 High-Viscosity Bone Cement with Gentamicin, https:\/\/www.heraeus-medical.com\/en\/healthcare-professionals\/products\/palacos-rg\/<\/a>; 2024.<\/p>\n<\/li>\n

  • \n

    HeraeusMedical. COPAL\u00ae\u202fG+V \u2013 High-Viscosity Bone Cement with Gentamicin and Vancomycin, https:\/\/www.heraeus-medical.com\/en-us\/healthcare-professionals\/products\/copal-gv\/<\/a>; 2024.<\/p>\n<\/li>\n

  • \n

    HeraeusMedical. PALACOS\u00ae R \u2013 High-Viscosity Bone Cement without Antibiotics, https:\/\/www.heraeus-medical.com\/en\/healthcare-professionals\/products\/palacos-r\/<\/a>; 2024.<\/p>\n<\/li>\n

  • \n

    Lunz A, Knappe K, Omlor GW, Schonhoff M, Renkawitz T, Jaeger S. Mechanical strength of antibiotic-loaded PMMA spacers in two-stage revision surgery. BMC Musculoskelet Disord. 2022;23(1):945.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Schonhoff M, Bormann T, Knappe K, Reiner T, Stange L, Jaeger S. The effect of cement aging on the stability of a cement-in-cement revision construct. Appl Sci. 2021. https:\/\/doi.org\/10.3390\/app11062814<\/a>.<\/p>\n

    Article<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Breusch SJ, Norman TL, Schneider U, Reitzel T, Blaha JD, Lukoschek M. Lavage technique in total hip arthroplasty: jet lavage produces better cement penetration than syringe lavage in the proximal femur. J Arthroplasty. 2000;15(7):921\u20137.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Clarius M, Hauck C, Seeger JB, James A, Murray DW, Aldinger PR. Pulsed lavage reduces the incidence of radiolucent lines under the tibial tray of Oxford unicompartmental knee arthroplasty: pulsed lavage versus syringe lavage. Int Orthop. 2009;33(6):1585\u201390.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Kalteis T, Pforringer D, Herold T, Handel M, Renkawitz T, Plitz W. An experimental comparison of different devices for pulsatile high-pressure lavage and their relevance to cement intrusion into cancellous bone. Arch Orthop Trauma Surg. 2007;127(10):873\u20137.<\/p>\n

    PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Seeger JB, Jaeger S, Bitsch RG, Mohr G, Rohner E, Clarius M. The effect of bone lavage on femoral cement penetration and interface temperature during Oxford unicompartmental knee arthroplasty with cement. J Bone Joint Surg Am. 2013;95(1):48\u201353.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Poilvache H, Ruiz-Sorribas A, Sakoulas G, Rodriguez-Villalobos H, Cornu O, Van Bambeke F. Synergistic effects of pulsed lavage and antimicrobial therapy against Staphylococcus aureus biofilms in an in-vitro model. Front Med (Lausanne). 2020;7:527.<\/p>\n

    PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Knecht CS, Moley JP, McGrath MS, Granger JF, Stoodley P, Dusane DH. Antibiotic loaded calcium sulfate bead and pulse lavage eradicates biofilms on metal implant materials in vitro. J Orthop Res. 2018;36(9):2349\u201354.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Marks KE, Nelson CL, Lautenschlager EP. Antibiotic-impregnated acrylic bone cement. J Bone Joint Surg Am. 1976;58(3):358\u201364.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Schurman DJ, Trindade C, Hirshman HP, Moser K, Kajiyama G, Stevens P. Antibiotic-acrylic bone cement composites. Studies of gentamicin and Palacos. J Bone Joint Surg Am. 1978;60(7):978\u201384.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Welch A. Antibiotics in acrylic bone cement. In vitro studies. J Biomed Mater Res. 1978;12(5):679\u2013700.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Bistolfi A, Massazza G, Verne E, et al. Antibiotic-loaded cement in orthopedic surgery: a review. ISRN Orthop. 2011;2011:290851.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Cieremans D, Muthusamy N, Singh V, Rozell JC, Aggarwal V, Schwarzkopf R. Does antibiotic bone cement reduce infection rates in primary total knee arthroplasty? Eur J Orthop Surg Traumatol. 2023;33(8):3379\u201385.<\/p>\n

    PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Wang J, Zhu C, Cheng T, et al. A systematic review and meta-analysis of antibiotic-impregnated bone cement use in primary total hip or knee arthroplasty. PLoS ONE. 2013;8(12):e82745.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Xu T, Wu KL, Jie K. Comprehensive meta-analysis of antibiotic-impregnated bone cement versus plain bone cement in primary total knee arthroplasty for preventing periprosthetic joint infection. Chin J Traumatol. 2022;25(6):325\u201330.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Druel T, Vanpoulle G, Michard R, et al. Influence of the anatomy of the proximal articular surface of the trapezium (PAST) and the trapezoidal articular surface of the trapezium (TRAST) in cup placement during trapeziometacarpal arthroplasty. Hand Surg Rehabil. 2024. https:\/\/doi.org\/10.1016\/j.hansur.2023.12.004<\/a>.<\/p>\n

    Article<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Moore RD, Lietman PS, Smith CR. Clinical response to aminoglycoside therapy: importance of the ratio of peak concentration to minimal inhibitory concentration. J Infect Dis. 1987;155(1):93\u20139.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Raveh D, Kopyt M, Hite Y, Rudensky B, Sonnenblick M, Yinnon AM. Risk factors for nephrotoxicity in elderly patients receiving once-daily aminoglycosides. QJM. 2002;95(5):291\u20137.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Selby NM, Shaw S, Woodier N, Fluck RJ, Kolhe NV. Gentamicin-associated acute kidney injury. QJM. 2009;102(12):873\u201380.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Yamada T, Fujii S, Shigemi A, Takesue Y. A meta-analysis of the target trough concentration of gentamicin and amikacin for reducing the risk of nephrotoxicity. J Infect Chemother. 2021;27(2):256\u201361.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Mazza D, Calderaro C, Iorio R, Drogo P, Andreozzi V, Ferretti A. Acute kidney failure after total knee arthroplasty revision with antibiotic-impregnated cement spacer. Orthop Rev (Pavia). 2020;12(2):8540.<\/p>\n

    PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Hodiamont CJ, van den Broek AK, de Vroom SL, Prins JM, Mathot RAA, van Hest RM. Clinical pharmacokinetics of gentamicin in various patient populations and consequences for optimal dosing for gram-negative infections: an updated review. Clin Pharmacokinet. 2022;61(8):1075\u201394.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Curtis JM, Sternhagen V, Batts D. Acute renal failure after placement of tobramycin-impregnated bone cement in an infected total knee arthroplasty. Pharmacotherapy. 2005;25(6):876\u201380.<\/p>\n

    PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Patrick BN, Rivey MP, Allington DR. Acute renal failure associated with vancomycin- and tobramycin-laden cement in total hip arthroplasty. Ann Pharmacother. 2006;40(11):2037\u201342.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Amerstorfer F, Fischerauer S, Sadoghi P, et al. Superficial vancomycin coating of bone cement in orthopedic revision surgery: a safe technique to enhance local antibiotic concentrations. J Arthroplasty. 2017;32(5):1618\u201324.<\/p>\n

    PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Burns AWR, Chao T, Tsai N, Lynch JT, Smith PN. The use of intra-articular vancomycin is safe in primary hip and knee arthroplasty. J Orthop. 2023;46:161\u20133.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Hsieh PH, Chang YH, Chen SH, Ueng SW, Shih CH. High concentration and bioactivity of vancomycin and aztreonam eluted from Simplex cement spacers in two-stage revision of infected hip implants: a study of 46 patients at an average follow-up of 107 days. J Orthop Res. 2006;24(8):1615\u201321.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Salvati EA, Callaghan JJ, Brause BD, Klein RF, Small RD. Reimplantation in infection. Elution of gentamicin from cement and beads. Clin Orthop Relat Res. 1986;207:83\u201393.<\/p>\n


    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Thomassen MB, Hanberg P, Stilling M, et al. Local concentrations of gentamicin obtained by microdialysis after a controlled application of a GentaColl sponge in a porcine model. J Orthop Res. 2020;38(8):1793\u20139.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Springer BD, Lee GC, Osmon D, Haidukewych GJ, Hanssen AD, Jacofsky DJ. Systemic safety of high-dose antibiotic-loaded cement spacers after resection of an infected total knee arthroplasty. Clin Orthop Relat Res. 2004;427:47\u201351.<\/p>\n


    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Migliorini F, Weber CD, Bell A, et al. Bacterial pathogens and in-hospital mortality in revision surgery for periprosthetic joint infection of the hip and knee: analysis of 346 patients. Eur J Med Res. 2023;28(1):177.<\/p>\n

    PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Periprosthetic PR, Infection J. Periprosthetic joint infection. N Engl J Med. 2023;388(3):251\u201362.<\/p>\n


    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Villa JM, Pannu TS, Theeb I, et al. International organism profile of periprosthetic total hip and knee infections. J Arthroplasty. 2021;36(1):274\u20138.<\/p>\n

    PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Zimmerli W, Trampuz A, Ochsner PE. Prosthetic-joint infections. N Engl J Med. 2004;351(16):1645\u201354.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Alvarez R, Lopez Cortes LE, Molina J, Cisneros JM, Pachon J. Optimizing the clinical use of vancomycin. Antimicrob Agents Chemother. 2016;60(5):2601\u20139.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Diaz R, Afreixo V, Ramalheira E, Rodrigues C, Gago B. Evaluation of vancomycin MIC creep in methicillin-resistant Staphylococcus aureus infections-a systematic review and meta-analysis. Clin Microbiol Infect. 2018;24(2):97\u2013104.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Sorensen TS, Sorensen AI. Bactericidal activity of gentamicin against S. aureus. In vitro study questions value of prolonged high concentrations. Acta Orthop Scand. 1993;64(1):82\u20134.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Craig WA, Ebert SC. Killing and regrowth of bacteria in vitro: a review. Scand J Infect Dis Suppl. 1990;74:63\u201370.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Dalton BR. What is the best vancomycin therapeutic drug monitoring parameter to assess efficacy? A critical review of experimental data and assessment of the need for individual patient minimum inhibitory concentration value. Microorganisms. 2023. https:\/\/doi.org\/10.3390\/microorganisms11030567<\/a>.<\/p>\n

    Article<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Elbarbry F. Vancomycin dosing and monitoring: critical evaluation of the current practice. Eur J Drug Metab Pharmacokinet. 2018;43(3):259\u201368.<\/p>\n

    CAS<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Ye ZK, Chen YL, Chen K, et al. Therapeutic drug monitoring of vancomycin: a guideline of the division of therapeutic drug monitoring. Chin Pharmacol Soc J Antimicrob Chemother. 2016;71(11):3020\u20135.<\/p>\n


    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    N\u2019Diaye M, Pascaretti-Grizon F, Massin P, Basle MF, Chappard D. Water absorption of poly(methyl methacrylate) measured by vertical interference microscopy. Langmuir. 2012;28(31):11609\u201314.<\/p>\n

    PubMed<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n

  • \n

    Chen IC, Su CY, Nien WH, et al. Influence of antibiotic-loaded acrylic bone cement composition on drug release behavior and mechanism. Polymers (Basel). 2021. https:\/\/doi.org\/10.3390\/polym13142240<\/a>.<\/p>\n

    Article<\/a>\u00a0
    \n     PubMed<\/a>\u00a0
    \n     PubMed Central<\/a>\u00a0
    \n
    \n Google Scholar<\/a>\u00a0\n <\/p>\n<\/li>\n","protected":false},"excerpt":{"rendered":"James I, Huddleston I, MD. Annual Report 2024. American Academy of Orthopaedic Surgeons\u2014American Joint Replacement Registry. 11. https:\/\/www.aaos.org\/registries\/publications\/ajrr-annual-report\/…\n","protected":false},"author":2,"featured_media":188720,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[78],"tags":[105698,18,105699,135,19,17,44111,105694,105695,105697,93957,105696,105700],"class_list":{"0":"post-188719","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-antibiotic-loaded-bone-cement","9":"tag-eire","10":"tag-gentamicin","11":"tag-health","12":"tag-ie","13":"tag-ireland","14":"tag-orthopedics","15":"tag-periprosthetic-joint-infections-pji","16":"tag-pulsatile-lavage","17":"tag-spacer","18":"tag-surgical-orthopedics","19":"tag-two-stage-revision","20":"tag-vancomycin"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@ie\/115575698460017862","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts\/188719","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/comments?post=188719"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts\/188719\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/media\/188720"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/media?parent=188719"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/categories?post=188719"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/tags?post=188719"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}