{"id":192371,"date":"2025-11-21T10:25:09","date_gmt":"2025-11-21T10:25:09","guid":{"rendered":"https:\/\/www.europesays.com\/ie\/192371\/"},"modified":"2025-11-21T10:25:09","modified_gmt":"2025-11-21T10:25:09","slug":"the-heme-binding-protein-hemopexin-promotes-functional-recovery-and-tissue-protection-after-spinal-cord-injury-via-sex-specific-regulation-of-inflammation-and-ferroptosis-journal-of-neuroinflammatio","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/ie\/192371\/","title":{"rendered":"The heme-binding protein hemopexin promotes functional recovery and tissue protection after spinal cord injury via sex-specific regulation of inflammation and ferroptosis | Journal of Neuroinflammation"},"content":{"rendered":"<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"1.\">\n<p class=\"c-article-references__text\" id=\"ref-CR1\">Sekhon LH, Fehlings MG. Epidemiology, demographics, and pathophysiology of acute spinal cord injury. Spine (Phila Pa 1976). 2001;26:S2\u201312. <a href=\"https:\/\/doi.org\/10.1097\/00007632-200112151-00002\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1097\/00007632-200112151-00002\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1097\/00007632-200112151-00002<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 1\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Epidemiology%2C%20demographics%2C%20and%20pathophysiology%20of%20acute%20spinal%20cord%20injury&amp;journal=Spine%20%28Phila%20Pa%201976%29&amp;doi=10.1097%2F00007632-200112151-00002&amp;volume=26&amp;pages=S2-12&amp;publication_year=2001&amp;author=Sekhon%2CLH&amp;author=Fehlings%2CMG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"2.\">\n<p class=\"c-article-references__text\" id=\"ref-CR2\">Shah M, Peterson C, Yilmaz E, Halalmeh DR, Moisi M. Current advancements in the management of spinal cord injury: A comprehensive review of literature. Surg Neurol Int. 2020;11(2). <a href=\"https:\/\/doi.org\/10.25259\/SNI_568_2019\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.25259\/SNI_568_2019\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.25259\/SNI_568_2019<\/a>.<\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"3.\">\n<p class=\"c-article-references__text\" id=\"ref-CR3\">Donnelly DJ, Popovich PG. Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury. Exp Neurol. 2008;209:378\u201388. <a href=\"https:\/\/doi.org\/10.1016\/j.expneurol.2007.06.009\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/j.expneurol.2007.06.009\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.expneurol.2007.06.009<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 3\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Inflammation%20and%20its%20role%20in%20neuroprotection%2C%20axonal%20regeneration%20and%20functional%20recovery%20after%20spinal%20cord%20injury&amp;journal=Exp%20Neurol&amp;doi=10.1016%2Fj.expneurol.2007.06.009&amp;volume=209&amp;pages=378-88&amp;publication_year=2008&amp;author=Donnelly%2CDJ&amp;author=Popovich%2CPG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"4.\">\n<p class=\"c-article-references__text\" id=\"ref-CR4\">Hilton BJ, Moulson AJ, Tetzlaff W. Neuroprotection and secondary damage following spinal cord injury: concepts and methods. Neurosci Lett. 2017;652:3\u201310. <a href=\"https:\/\/doi.org\/10.1016\/j.neulet.2016.12.004\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/j.neulet.2016.12.004\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.neulet.2016.12.004<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 4\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Neuroprotection%20and%20secondary%20damage%20following%20spinal%20cord%20injury%3A%20concepts%20and%20methods&amp;journal=Neurosci%20Lett&amp;doi=10.1016%2Fj.neulet.2016.12.004&amp;volume=652&amp;pages=3-10&amp;publication_year=2017&amp;author=Hilton%2CBJ&amp;author=Moulson%2CAJ&amp;author=Tetzlaff%2CW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"5.\">\n<p class=\"c-article-references__text\" id=\"ref-CR5\">Scivoletto G, Tamburella F, Laurenza L, Torre M, Molinari M. Who is going to walk? A review of the factors influencing walking recovery after spinal cord injury. Front Hum Neurosci. 2014;8:141. <a href=\"https:\/\/doi.org\/10.3389\/fnhum.2014.00141\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3389\/fnhum.2014.00141\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3389\/fnhum.2014.00141<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 5\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Who%20is%20going%20to%20walk%3F%20A%20review%20of%20the%20factors%20influencing%20walking%20recovery%20after%20spinal%20cord%20injury&amp;journal=Front%20Hum%20Neurosci&amp;doi=10.3389%2Ffnhum.2014.00141&amp;volume=8&amp;publication_year=2014&amp;author=Scivoletto%2CG&amp;author=Tamburella%2CF&amp;author=Laurenza%2CL&amp;author=Torre%2CM&amp;author=Molinari%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"6.\">\n<p class=\"c-article-references__text\" id=\"ref-CR6\">Dalkilic T, Fallah N, Noonan VK, Salimi Elizei S, Dong K, Belanger L, et al. Predicting injury severity and neurological recovery after acute cervical spinal cord injury: a comparison of cerebrospinal fluid and magnetic resonance imaging biomarkers. J Neurotrauma. 2018;35:435\u201345. <a href=\"https:\/\/doi.org\/10.1089\/neu.2017.5357\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1089\/neu.2017.5357\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1089\/neu.2017.5357<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 6\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Predicting%20injury%20severity%20and%20neurological%20recovery%20after%20acute%20cervical%20spinal%20cord%20injury%3A%20a%20comparison%20of%20cerebrospinal%20fluid%20and%20magnetic%20resonance%20imaging%20biomarkers&amp;journal=J%20Neurotrauma&amp;doi=10.1089%2Fneu.2017.5357&amp;volume=35&amp;pages=435-45&amp;publication_year=2018&amp;author=Dalkilic%2CT&amp;author=Fallah%2CN&amp;author=Noonan%2CVK&amp;author=Salimi%20Elizei%2CS&amp;author=Dong%2CK&amp;author=Belanger%2CL&amp;author=Ritchie%2CL&amp;author=Tsang%2CA&amp;author=Bourassa-Moreau%2CE&amp;author=Heran%2CMKS&amp;author=Paquette%2CSJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"7.\">\n<p class=\"c-article-references__text\" id=\"ref-CR7\">Losey P, Young C, Krimholtz E, Bordet R, Anthony DC. The role of hemorrhage following spinal-cord injury. Brain Res. 2014;1569:9\u201318. <a href=\"https:\/\/doi.org\/10.1016\/j.brainres.2014.04.033\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/j.brainres.2014.04.033\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.brainres.2014.04.033<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 7\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20role%20of%20hemorrhage%20following%20spinal-cord%20injury&amp;journal=Brain%20Res&amp;doi=10.1016%2Fj.brainres.2014.04.033&amp;volume=1569&amp;pages=9-18&amp;publication_year=2014&amp;author=Losey%2CP&amp;author=Young%2CC&amp;author=Krimholtz%2CE&amp;author=Bordet%2CR&amp;author=Anthony%2CDC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"8.\">\n<p class=\"c-article-references__text\" id=\"ref-CR8\">Wu J, Hua Y, Keep RF, Nakamura T, Hoff JT, Xi G. Iron and iron-handling proteins in the brain after intracerebral hemorrhage. Stroke. 2003;34:2964\u20139. <a href=\"https:\/\/doi.org\/10.1161\/01.STR.0000103140.52838.45\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1161\/01.STR.0000103140.52838.45\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1161\/01.STR.0000103140.52838.45<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 8\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Iron%20and%20iron-handling%20proteins%20in%20the%20brain%20after%20intracerebral%20hemorrhage&amp;journal=Stroke&amp;doi=10.1161%2F01.STR.0000103140.52838.45&amp;volume=34&amp;pages=2964-9&amp;publication_year=2003&amp;author=Wu%2CJ&amp;author=Hua%2CY&amp;author=Keep%2CRF&amp;author=Nakamura%2CT&amp;author=Hoff%2CJT&amp;author=Xi%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"9.\">\n<p class=\"c-article-references__text\" id=\"ref-CR9\">Marlet JM, Jde BF, P. Experimental determination of time of intracranial hemorrhage by spectrophotometric analysis of cerebrospinal fluid. J Forensic Sci. 1982;27:880\u20138.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 9\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Experimental%20determination%20of%20time%20of%20intracranial%20hemorrhage%20by%20spectrophotometric%20analysis%20of%20cerebrospinal%20fluid&amp;journal=J%20Forensic%20Sci&amp;volume=27&amp;pages=880-8&amp;publication_year=1982&amp;author=Marlet%2CJM&amp;author=Jde%2CBF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"10.\">\n<p class=\"c-article-references__text\" id=\"ref-CR10\">Koeppen AH, Dickson AC, McEvoy JA. The cellular reactions to experimental intracerebral hemorrhage. J Neurol Sci. 1995;134:102\u201312. <a href=\"https:\/\/doi.org\/10.1016\/0022-510x(95)00215-n\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/0022-510x(95)00215-n\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/0022-510x(95)00215-n<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 10\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20cellular%20reactions%20to%20experimental%20intracerebral%20hemorrhage&amp;journal=J%20Neurol%20Sci&amp;doi=10.1016%2F0022-510x%2895%2900215-n&amp;volume=134&amp;pages=102-12&amp;publication_year=1995&amp;author=Koeppen%2CAH&amp;author=Dickson%2CAC&amp;author=McEvoy%2CJA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"11.\">\n<p class=\"c-article-references__text\" id=\"ref-CR11\">Figueiredo RT, Fernandez PL, Mourao-Sa DS, Porto BN, Dutra FF, Alves LS, et al. Characterization of heme as activator of toll-like receptor 4. J Biol Chem. 2007;282:20221\u20139. <a href=\"https:\/\/doi.org\/10.1074\/jbc.M610737200\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1074\/jbc.M610737200\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1074\/jbc.M610737200<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 11\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Characterization%20of%20heme%20as%20activator%20of%20toll-like%20receptor%204&amp;journal=J%20Biol%20Chem&amp;doi=10.1074%2Fjbc.M610737200&amp;volume=282&amp;pages=20221-9&amp;publication_year=2007&amp;author=Figueiredo%2CRT&amp;author=Fernandez%2CPL&amp;author=Mourao-Sa%2CDS&amp;author=Porto%2CBN&amp;author=Dutra%2CFF&amp;author=Alves%2CLS&amp;author=Oliveira%2CMF&amp;author=Oliveira%2CPL&amp;author=Graca-Souza%2CAV&amp;author=Bozza%2CMT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"12.\">\n<p class=\"c-article-references__text\" id=\"ref-CR12\">Schaer DJ, Buehler PW, Alayash AI, Belcher JD, Vercellotti GM. Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. Blood. 2013;121:1276\u201384. <a href=\"https:\/\/doi.org\/10.1182\/blood-2012-11-451229\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1182\/blood-2012-11-451229\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1182\/blood-2012-11-451229<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 12\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Hemolysis%20and%20free%20hemoglobin%20revisited%3A%20exploring%20hemoglobin%20and%20hemin%20scavengers%20as%20a%20novel%20class%20of%20therapeutic%20proteins&amp;journal=Blood&amp;doi=10.1182%2Fblood-2012-11-451229&amp;volume=121&amp;pages=1276-84&amp;publication_year=2013&amp;author=Schaer%2CDJ&amp;author=Buehler%2CPW&amp;author=Alayash%2CAI&amp;author=Belcher%2CJD&amp;author=Vercellotti%2CGM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"13.\">\n<p class=\"c-article-references__text\" id=\"ref-CR13\">Schaer DJ, Vinchi F, Ingoglia G, Tolosano E, Buehler PW. Haptoglobin, hemopexin, and related defense pathways\u00e2\u20ac\u201dbasic science, clinical perspectives, and drug development. Front Physiol. 2014;5:415. <a href=\"https:\/\/doi.org\/10.3389\/fphys.2014.00415\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3389\/fphys.2014.00415\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3389\/fphys.2014.00415<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 13\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Haptoglobin%2C%20hemopexin%2C%20and%20related%20defense%20pathways%C3%A2%E2%82%AC%E2%80%9Dbasic%20science%2C%20clinical%20perspectives%2C%20and%20drug%20development&amp;journal=Front%20Physiol&amp;doi=10.3389%2Ffphys.2014.00415&amp;volume=5&amp;publication_year=2014&amp;author=Schaer%2CDJ&amp;author=Vinchi%2CF&amp;author=Ingoglia%2CG&amp;author=Tolosano%2CE&amp;author=Buehler%2CPW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"14.\">\n<p class=\"c-article-references__text\" id=\"ref-CR14\">Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149:1060\u201372. <a href=\"https:\/\/doi.org\/10.1016\/j.cell.2012.03.042\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/j.cell.2012.03.042\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.cell.2012.03.042<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 14\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Ferroptosis%3A%20an%20iron-dependent%20form%20of%20nonapoptotic%20cell%20death&amp;journal=Cell&amp;doi=10.1016%2Fj.cell.2012.03.042&amp;volume=149&amp;pages=1060-72&amp;publication_year=2012&amp;author=Dixon%2CSJ&amp;author=Lemberg%2CKM&amp;author=Lamprecht%2CMR&amp;author=Skouta%2CR&amp;author=Zaitsev%2CEM&amp;author=Gleason%2CCE&amp;author=Patel%2CDN&amp;author=Bauer%2CAJ&amp;author=Cantley%2CAM&amp;author=Yang%2CWS&amp;author=Morrison%2CB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"15.\">\n<p class=\"c-article-references__text\" id=\"ref-CR15\">Ryan F, Blex C, Ngo TD, Kopp MA, Michalke B, Venkataramani V, et al. Ferroptosis inhibitor improves outcome after early and delayed treatment in mild spinal cord injury. Acta Neuropathol. 2024;147:106. <a href=\"https:\/\/doi.org\/10.1007\/s00401-024-02758-2\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1007\/s00401-024-02758-2\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1007\/s00401-024-02758-2<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 15\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Ferroptosis%20inhibitor%20improves%20outcome%20after%20early%20and%20delayed%20treatment%20in%20mild%20spinal%20cord%20injury&amp;journal=Acta%20Neuropathol&amp;doi=10.1007%2Fs00401-024-02758-2&amp;volume=147&amp;publication_year=2024&amp;author=Ryan%2CF&amp;author=Blex%2CC&amp;author=Ngo%2CTD&amp;author=Kopp%2CMA&amp;author=Michalke%2CB&amp;author=Venkataramani%2CV&amp;author=Curran%2CL&amp;author=Schwab%2CJM&amp;author=Ruprecht%2CK&amp;author=Otto%2CC&amp;author=Jhelum%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"16.\">\n<p class=\"c-article-references__text\" id=\"ref-CR16\">Jhelum P, Zandee S, Ryan F, Zarruk JG, Michalke B, Venkataramani V, et al. Ferroptosis induces detrimental effects in chronic EAE and its implications for progressive MS. Acta Neuropathol Commun. 2023;11:121. <a href=\"https:\/\/doi.org\/10.1186\/s40478-023-01617-7\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1186\/s40478-023-01617-7\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1186\/s40478-023-01617-7<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 16\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Ferroptosis%20induces%20detrimental%20effects%20in%20chronic%20EAE%20and%20its%20implications%20for%20progressive%20MS&amp;journal=Acta%20Neuropathol%20Commun&amp;doi=10.1186%2Fs40478-023-01617-7&amp;volume=11&amp;publication_year=2023&amp;author=Jhelum%2CP&amp;author=Zandee%2CS&amp;author=Ryan%2CF&amp;author=Zarruk%2CJG&amp;author=Michalke%2CB&amp;author=Venkataramani%2CV&amp;author=Curran%2CL&amp;author=Klement%2CW&amp;author=Prat%2CA&amp;author=David%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"17.\">\n<p class=\"c-article-references__text\" id=\"ref-CR17\">David S, Ryan F, Jhelum P, Kroner A. Ferroptosis Neurol Disease Neuroscientist. 2023;29:591\u2013615. <a href=\"https:\/\/doi.org\/10.1177\/10738584221100183\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1177\/10738584221100183\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1177\/10738584221100183<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 17\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=&amp;journal=Ferroptosis%20Neurol%20Disease%20Neuroscientist&amp;doi=10.1177%2F10738584221100183&amp;volume=29&amp;pages=591-615&amp;publication_year=2023&amp;author=David%2CS&amp;author=Ryan%2CF&amp;author=Jhelum%2CP&amp;author=Kroner%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"18.\">\n<p class=\"c-article-references__text\" id=\"ref-CR18\">Schaer CA, Deuel JW, Bittermann AG, Rubio IG, Schoedon G, Spahn DR, et al. Mechanisms of haptoglobin protection against hemoglobin peroxidation triggered endothelial damage. Cell Death Differ. 2013;20:1569\u201379. <a href=\"https:\/\/doi.org\/10.1038\/cdd.2013.113\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1038\/cdd.2013.113\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1038\/cdd.2013.113<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 18\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Mechanisms%20of%20haptoglobin%20protection%20against%20hemoglobin%20peroxidation%20triggered%20endothelial%20damage&amp;journal=Cell%20Death%20Differ&amp;doi=10.1038%2Fcdd.2013.113&amp;volume=20&amp;pages=1569-79&amp;publication_year=2013&amp;author=Schaer%2CCA&amp;author=Deuel%2CJW&amp;author=Bittermann%2CAG&amp;author=Rubio%2CIG&amp;author=Schoedon%2CG&amp;author=Spahn%2CDR&amp;author=Wepf%2CRA&amp;author=Vallelian%2CF&amp;author=Schaer%2CDJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"19.\">\n<p class=\"c-article-references__text\" id=\"ref-CR19\">Lin S, Yin Q, Zhong Q, Lv FL, Zhou Y, Li JQ, Wang JZ, Su BY, Yang QW. Heme activates TLR4-mediated inflammatory injury via MyD88\/TRIF signaling pathway in intracerebral hemorrhage. J Neuroinflammation. 2012;9:46. <a href=\"https:\/\/doi.org\/10.1186\/1742-2094-9-46\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1186\/1742-2094-9-46\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1186\/1742-2094-9-46<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 19\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Heme%20activates%20TLR4-mediated%20inflammatory%20injury%20via%20MyD88%2FTRIF%20signaling%20pathway%20in%20intracerebral%20hemorrhage&amp;journal=J%20Neuroinflammation&amp;doi=10.1186%2F1742-2094-9-46&amp;volume=9&amp;publication_year=2012&amp;author=Lin%2CS&amp;author=Yin%2CQ&amp;author=Zhong%2CQ&amp;author=Lv%2CFL&amp;author=Zhou%2CY&amp;author=Li%2CJQ&amp;author=Wang%2CJZ&amp;author=Su%2CBY&amp;author=Yang%2CQW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"20.\">\n<p class=\"c-article-references__text\" id=\"ref-CR20\">Vallelian F, Deuel JW, Opitz L, Schaer CA, Puglia M, Lonn M, et al. Proteasome inhibition and oxidative reactions disrupt cellular homeostasis during heme stress. Cell Death Differ. 2015;22:597\u2013611. <a href=\"https:\/\/doi.org\/10.1038\/cdd.2014.154\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1038\/cdd.2014.154\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1038\/cdd.2014.154<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 20\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Proteasome%20inhibition%20and%20oxidative%20reactions%20disrupt%20cellular%20homeostasis%20during%20heme%20stress&amp;journal=Cell%20Death%20Differ&amp;doi=10.1038%2Fcdd.2014.154&amp;volume=22&amp;pages=597-611&amp;publication_year=2015&amp;author=Vallelian%2CF&amp;author=Deuel%2CJW&amp;author=Opitz%2CL&amp;author=Schaer%2CCA&amp;author=Puglia%2CM&amp;author=Lonn%2CM&amp;author=Engelsberger%2CW&amp;author=Schauer%2CS&amp;author=Karnaukhova%2CE&amp;author=Spahn%2CDR&amp;author=Stocker%2CR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"21.\">\n<p class=\"c-article-references__text\" id=\"ref-CR21\">Zhao X, Sun G, Zhang J, Strong R, Dash PK, Kan YW, et al. Transcription factor Nrf2 protects the brain from damage produced by intracerebral hemorrhage. Stroke. 2007;38:3280\u20136. <a href=\"https:\/\/doi.org\/10.1161\/STROKEAHA.107.486506\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1161\/STROKEAHA.107.486506\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1161\/STROKEAHA.107.486506<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 21\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Transcription%20factor%20Nrf2%20protects%20the%20brain%20from%20damage%20produced%20by%20intracerebral%20hemorrhage&amp;journal=Stroke&amp;doi=10.1161%2FSTROKEAHA.107.486506&amp;volume=38&amp;pages=3280-6&amp;publication_year=2007&amp;author=Zhao%2CX&amp;author=Sun%2CG&amp;author=Zhang%2CJ&amp;author=Strong%2CR&amp;author=Dash%2CPK&amp;author=Kan%2CYW&amp;author=Grotta%2CJC&amp;author=Aronowski%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"22.\">\n<p class=\"c-article-references__text\" id=\"ref-CR22\">Wang J, Fields J, Zhao C, Langer J, Thimmulappa RK, Kensler TW, et al. Role of Nrf2 in protection against intracerebral hemorrhage injury in mice. Free Radic Biol Med. 2007;43:408\u201314. <a href=\"https:\/\/doi.org\/10.1016\/j.freeradbiomed.2007.04.020\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/j.freeradbiomed.2007.04.020\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.freeradbiomed.2007.04.020<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 22\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Role%20of%20Nrf2%20in%20protection%20against%20intracerebral%20hemorrhage%20injury%20in%20mice&amp;journal=Free%20Radic%20Biol%20Med&amp;doi=10.1016%2Fj.freeradbiomed.2007.04.020&amp;volume=43&amp;pages=408-14&amp;publication_year=2007&amp;author=Wang%2CJ&amp;author=Fields%2CJ&amp;author=Zhao%2CC&amp;author=Langer%2CJ&amp;author=Thimmulappa%2CRK&amp;author=Kensler%2CTW&amp;author=Yamamoto%2CM&amp;author=Biswal%2CS&amp;author=Dore%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"23.\">\n<p class=\"c-article-references__text\" id=\"ref-CR23\">Hvidberg V, Maniecki MB, Jacobsen C, Hojrup P, Moller HJ, Moestrup SK. Identification of the receptor scavenging hemopexin-heme complexes. Blood. 2005;106:2572\u20139. <a href=\"https:\/\/doi.org\/10.1182\/blood-2005-03-1185\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1182\/blood-2005-03-1185\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1182\/blood-2005-03-1185<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 23\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Identification%20of%20the%20receptor%20scavenging%20hemopexin-heme%20complexes&amp;journal=Blood&amp;doi=10.1182%2Fblood-2005-03-1185&amp;volume=106&amp;pages=2572-9&amp;publication_year=2005&amp;author=Hvidberg%2CV&amp;author=Maniecki%2CMB&amp;author=Jacobsen%2CC&amp;author=Hojrup%2CP&amp;author=Moller%2CHJ&amp;author=Moestrup%2CSK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"24.\">\n<p class=\"c-article-references__text\" id=\"ref-CR24\">Shih AW, McFarlane A, Verhovsek H. Haptoglobin testing in hemolysis: measurement and interpretation. Am J Hematol. 2014;89:443\u20137. <a href=\"https:\/\/doi.org\/10.1002\/ajh.23623\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1002\/ajh.23623\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1002\/ajh.23623<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 24\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Haptoglobin%20testing%20in%20hemolysis%3A%20measurement%20and%20interpretation&amp;journal=Am%20J%20Hematol&amp;doi=10.1002%2Fajh.23623&amp;volume=89&amp;pages=443-7&amp;publication_year=2014&amp;author=Shih%2CAW&amp;author=McFarlane%2CA&amp;author=Verhovsek%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"25.\">\n<p class=\"c-article-references__text\" id=\"ref-CR25\">Galea J, Cruickshank G, Teeling JL, Boche D, Garland P, Perry VH, et al. The intrathecal CD163-haptoglobin-hemoglobin scavenging system in subarachnoid hemorrhage. J Neurochem. 2012;121:785\u201392. <a href=\"https:\/\/doi.org\/10.1111\/j.1471-4159.2012.07716.x\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1111\/j.1471-4159.2012.07716.x\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1111\/j.1471-4159.2012.07716.x<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 25\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20intrathecal%20CD163-haptoglobin-hemoglobin%20scavenging%20system%20in%20subarachnoid%20hemorrhage&amp;journal=J%20Neurochem&amp;doi=10.1111%2Fj.1471-4159.2012.07716.x&amp;volume=121&amp;pages=785-92&amp;publication_year=2012&amp;author=Galea%2CJ&amp;author=Cruickshank%2CG&amp;author=Teeling%2CJL&amp;author=Boche%2CD&amp;author=Garland%2CP&amp;author=Perry%2CVH&amp;author=Galea%2CI\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"26.\">\n<p class=\"c-article-references__text\" id=\"ref-CR26\">Zhao X, Song S, Sun G, Strong R, Zhang J, Grotta JC, et al. Neuroprotective role of haptoglobin after intracerebral hemorrhage. J Neurosci. 2009;29:15819\u201327. <a href=\"https:\/\/doi.org\/10.1523\/JNEUROSCI.3776-09.2009\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1523\/JNEUROSCI.3776-09.2009\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1523\/JNEUROSCI.3776-09.2009<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 26\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Neuroprotective%20role%20of%20haptoglobin%20after%20intracerebral%20hemorrhage&amp;journal=J%20Neurosci&amp;doi=10.1523%2FJNEUROSCI.3776-09.2009&amp;volume=29&amp;pages=15819-27&amp;publication_year=2009&amp;author=Zhao%2CX&amp;author=Song%2CS&amp;author=Sun%2CG&amp;author=Strong%2CR&amp;author=Zhang%2CJ&amp;author=Grotta%2CJC&amp;author=Aronowski%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"27.\">\n<p class=\"c-article-references__text\" id=\"ref-CR27\">Chen L, Zhang X, Chen-Roetling J, Regan RF. Increased striatal injury and behavioral deficits after intracerebral hemorrhage in hemopexin knockout mice. J Neurosurg. 2011;114:1159\u201367. <a href=\"https:\/\/doi.org\/10.3171\/2010.10.JNS10861\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3171\/2010.10.JNS10861\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3171\/2010.10.JNS10861<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 27\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Increased%20striatal%20injury%20and%20behavioral%20deficits%20after%20intracerebral%20hemorrhage%20in%20hemopexin%20knockout%20mice&amp;journal=J%20Neurosurg&amp;doi=10.3171%2F2010.10.JNS10861&amp;volume=114&amp;pages=1159-67&amp;publication_year=2011&amp;author=Chen%2CL&amp;author=Zhang%2CX&amp;author=Chen-Roetling%2CJ&amp;author=Regan%2CRF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"28.\">\n<p class=\"c-article-references__text\" id=\"ref-CR28\">Ma B, Day JP, Phillips H, Slootsky B, Tolosano E, Dore S. Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage. J Neuroinflammation. 2016;13:26. <a href=\"https:\/\/doi.org\/10.1186\/s12974-016-0490-1\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1186\/s12974-016-0490-1\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1186\/s12974-016-0490-1<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 28\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Deletion%20of%20the%20hemopexin%20or%20heme%20oxygenase-2%20gene%20aggravates%20brain%20injury%20following%20stroma-free%20hemoglobin-induced%20intracerebral%20hemorrhage&amp;journal=J%20Neuroinflammation&amp;doi=10.1186%2Fs12974-016-0490-1&amp;volume=13&amp;publication_year=2016&amp;author=Ma%2CB&amp;author=Day%2CJP&amp;author=Phillips%2CH&amp;author=Slootsky%2CB&amp;author=Tolosano%2CE&amp;author=Dore%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"29.\">\n<p class=\"c-article-references__text\" id=\"ref-CR29\">Hahl P, Davis T, Washburn C, Rogers JT, Smith A. Mechanisms of neuroprotection by hemopexin: modeling the control of heme and iron homeostasis in brain neurons in inflammatory states. J Neurochem. 2013;125:89\u2013101. <a href=\"https:\/\/doi.org\/10.1111\/jnc.12165\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1111\/jnc.12165\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1111\/jnc.12165<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 29\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Mechanisms%20of%20neuroprotection%20by%20hemopexin%3A%20modeling%20the%20control%20of%20heme%20and%20iron%20homeostasis%20in%20brain%20neurons%20in%20inflammatory%20states&amp;journal=J%20Neurochem&amp;doi=10.1111%2Fjnc.12165&amp;volume=125&amp;pages=89-101&amp;publication_year=2013&amp;author=Hahl%2CP&amp;author=Davis%2CT&amp;author=Washburn%2CC&amp;author=Rogers%2CJT&amp;author=Smith%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"30.\">\n<p class=\"c-article-references__text\" id=\"ref-CR30\">Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, Emerson M, et al. The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. PLoS Biol. 2020;18:e3000410. <a href=\"https:\/\/doi.org\/10.1371\/journal.pbio.3000410\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1371\/journal.pbio.3000410\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1371\/journal.pbio.3000410<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 30\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20ARRIVE%20guidelines%202.0%3A%20updated%20guidelines%20for%20reporting%20animal%20research&amp;journal=PLoS%20Biol&amp;doi=10.1371%2Fjournal.pbio.3000410&amp;volume=18&amp;publication_year=2020&amp;author=Percie%20du%20Sert%2CN&amp;author=Hurst%2CV&amp;author=Ahluwalia%2CA&amp;author=Alam%2CS&amp;author=Avey%2CMT&amp;author=Baker%2CM&amp;author=Browne%2CWJ&amp;author=Clark%2CA&amp;author=Cuthill%2CIC&amp;author=Dirnagl%2CU&amp;author=Emerson%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"31.\">\n<p class=\"c-article-references__text\" id=\"ref-CR31\">Tolosano E, Hirsch E, Patrucco E, Camaschella C, Navone R, Silengo L, et al. Defective recovery and severe renal damage after acute hemolysis in hemopexin-deficient mice. Blood. 1999;94:3906\u201314.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 31\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Defective%20recovery%20and%20severe%20renal%20damage%20after%20acute%20hemolysis%20in%20hemopexin-deficient%20mice&amp;journal=Blood&amp;volume=94&amp;pages=3906-14&amp;publication_year=1999&amp;author=Tolosano%2CE&amp;author=Hirsch%2CE&amp;author=Patrucco%2CE&amp;author=Camaschella%2CC&amp;author=Navone%2CR&amp;author=Silengo%2CL&amp;author=Altruda%2CF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"32.\">\n<p class=\"c-article-references__text\" id=\"ref-CR32\">Metz GA, Whishaw IQ. Cortical and subcortical lesions impair skilled walking in the ladder rung walking test: a new task to evaluate fore- and hindlimb stepping, placing, and co-ordination. J Neurosci Methods. 2002;115:169\u201379.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 32\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cortical%20and%20subcortical%20lesions%20impair%20skilled%20walking%20in%20the%20ladder%20rung%20walking%20test%3A%20a%20new%20task%20to%20evaluate%20fore-%20and%20hindlimb%20stepping%2C%20placing%2C%20and%20co-ordination&amp;journal=J%20Neurosci%20Methods&amp;volume=115&amp;pages=169-79&amp;publication_year=2002&amp;author=Metz%2CGA&amp;author=Whishaw%2CIQ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"33.\">\n<p class=\"c-article-references__text\" id=\"ref-CR33\">Pelisch N, Almanza R, Stehlik J, Aperi KE, B.V., and, Kroner A. CCL3 contributes to secondary damage after spinal cord injury. J Neuroinflammation. 2020;17:362. <a href=\"https:\/\/doi.org\/10.1186\/s12974-020-02037-3\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1186\/s12974-020-02037-3\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1186\/s12974-020-02037-3<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 33\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=CCL3%20contributes%20to%20secondary%20damage%20after%20spinal%20cord%20injury&amp;journal=J%20Neuroinflammation&amp;doi=10.1186%2Fs12974-020-02037-3&amp;volume=17&amp;publication_year=2020&amp;author=Pelisch%2CN&amp;author=Almanza%2CR&amp;author=Stehlik%2CJ&amp;author=Aperi%2CKE&amp;author=Kroner%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"34.\">\n<p class=\"c-article-references__text\" id=\"ref-CR34\">Pelisch N, Almanza JR, Stehlik KE, Aperi BV, Kroner A. Use of a Self-Delivering Anti-CCL3 FANA Oligonucleotide as an Innovative Approach to Target Inflammation after Spinal Cord Injury. Eneuro 8. Artn. 2021;0338-20.2021. <a href=\"https:\/\/doi.org\/10.1523\/eneuro.0338-20.2021\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1523\/eneuro.0338-20.2021\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1523\/eneuro.0338-20.2021<\/a>.<\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"35.\">\n<p class=\"c-article-references__text\" id=\"ref-CR35\">Kigerl KA, McGaughy VM, Popovich PG. Comparative analysis of lesion development and intraspinal inflammation in four strains of mice following spinal contusion injury. J Comp Neurol. 2006;494:578\u201394. <a href=\"https:\/\/doi.org\/10.1002\/cne.20827\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1002\/cne.20827\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1002\/cne.20827<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 35\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Comparative%20analysis%20of%20lesion%20development%20and%20intraspinal%20inflammation%20in%20four%20strains%20of%20mice%20following%20spinal%20contusion%20injury&amp;journal=J%20Comp%20Neurol&amp;doi=10.1002%2Fcne.20827&amp;volume=494&amp;pages=578-94&amp;publication_year=2006&amp;author=Kigerl%2CKA&amp;author=McGaughy%2CVM&amp;author=Popovich%2CPG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"36.\">\n<p class=\"c-article-references__text\" id=\"ref-CR36\">Tolosano E, Fagoonee S, Morello N, Vinchi F, Fiorito V. Heme scavenging and the other facets of hemopexin. Antioxid Redox Signal. 2010;12:305\u201320. <a href=\"https:\/\/doi.org\/10.1089\/ars.2009.2787\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1089\/ars.2009.2787\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1089\/ars.2009.2787<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 36\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Heme%20scavenging%20and%20the%20other%20facets%20of%20hemopexin&amp;journal=Antioxid%20Redox%20Signal&amp;doi=10.1089%2Fars.2009.2787&amp;volume=12&amp;pages=305-20&amp;publication_year=2010&amp;author=Tolosano%2CE&amp;author=Fagoonee%2CS&amp;author=Morello%2CN&amp;author=Vinchi%2CF&amp;author=Fiorito%2CV\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"37.\">\n<p class=\"c-article-references__text\" id=\"ref-CR37\">Greenhalgh AD, David S. Differences in the phagocytic response of microglia and peripheral macrophages after spinal cord injury and its effects on cell death. J Neurosci. 2014;34:6316\u201322. <a href=\"https:\/\/doi.org\/10.1523\/JNEUROSCI.4912-13.2014\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1523\/JNEUROSCI.4912-13.2014\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1523\/JNEUROSCI.4912-13.2014<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 37\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Differences%20in%20the%20phagocytic%20response%20of%20microglia%20and%20peripheral%20macrophages%20after%20spinal%20cord%20injury%20and%20its%20effects%20on%20cell%20death&amp;journal=J%20Neurosci&amp;doi=10.1523%2FJNEUROSCI.4912-13.2014&amp;volume=34&amp;pages=6316-22&amp;publication_year=2014&amp;author=Greenhalgh%2CAD&amp;author=David%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"38.\">\n<p class=\"c-article-references__text\" id=\"ref-CR38\">Brennan FH, Li Y, Wang C, Ma A, Guo Q, Li Y, et al. Microglia coordinate cellular interactions during spinal cord repair in mice. Nat Commun. 2022;13:4096. <a href=\"https:\/\/doi.org\/10.1038\/s41467-022-31797-0\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1038\/s41467-022-31797-0\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1038\/s41467-022-31797-0<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 38\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Microglia%20coordinate%20cellular%20interactions%20during%20spinal%20cord%20repair%20in%20mice&amp;journal=Nat%20Commun&amp;doi=10.1038%2Fs41467-022-31797-0&amp;volume=13&amp;publication_year=2022&amp;author=Brennan%2CFH&amp;author=Li%2CY&amp;author=Wang%2CC&amp;author=Ma%2CA&amp;author=Guo%2CQ&amp;author=Li%2CY&amp;author=Pukos%2CN&amp;author=Campbell%2CWA&amp;author=Witcher%2CKG&amp;author=Guan%2CZ&amp;author=Kigerl%2CKA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"39.\">\n<p class=\"c-article-references__text\" id=\"ref-CR39\">Morizawa YM, Hirayama Y, Ohno N, Shibata S, Shigetomi E, Sui Y, et al. Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway. Nat Commun. 2017;8:28. <a href=\"https:\/\/doi.org\/10.1038\/s41467-017-00037-1\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1038\/s41467-017-00037-1\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1038\/s41467-017-00037-1<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 39\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Reactive%20astrocytes%20function%20as%20phagocytes%20after%20brain%20ischemia%20via%20ABCA1-mediated%20pathway&amp;journal=Nat%20Commun&amp;doi=10.1038%2Fs41467-017-00037-1&amp;volume=8&amp;publication_year=2017&amp;author=Morizawa%2CYM&amp;author=Hirayama%2CY&amp;author=Ohno%2CN&amp;author=Shibata%2CS&amp;author=Shigetomi%2CE&amp;author=Sui%2CY&amp;author=Nabekura%2CJ&amp;author=Sato%2CK&amp;author=Okajima%2CF&amp;author=Takebayashi%2CH&amp;author=Okano%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"40.\">\n<p class=\"c-article-references__text\" id=\"ref-CR40\">Kwiecien JM, Dabrowski W, Dabrowska-Bouta B, Sulkowski G, Oakden W, Kwiecien-Delaney CJ, Yaron JR, Zhang L, Schutz L, Marzec-Kotarska B, Stanisz GJ, et al. Prolonged inflammation leads to ongoing damage after spinal cord injury. PLoS ONE. 2020;15:e0226584. <a href=\"https:\/\/doi.org\/10.1371\/journal.pone.0226584\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1371\/journal.pone.0226584\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1371\/journal.pone.0226584<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 40\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Prolonged%20inflammation%20leads%20to%20ongoing%20damage%20after%20spinal%20cord%20injury&amp;journal=PLoS%20ONE&amp;doi=10.1371%2Fjournal.pone.0226584&amp;volume=15&amp;publication_year=2020&amp;author=Kwiecien%2CJM&amp;author=Dabrowski%2CW&amp;author=Dabrowska-Bouta%2CB&amp;author=Sulkowski%2CG&amp;author=Oakden%2CW&amp;author=Kwiecien-Delaney%2CCJ&amp;author=Yaron%2CJR&amp;author=Zhang%2CL&amp;author=Schutz%2CL&amp;author=Marzec-Kotarska%2CB&amp;author=Stanisz%2CGJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"41.\">\n<p class=\"c-article-references__text\" id=\"ref-CR41\">Turtle JD, Henwood MK, Strain MM, Huang YJ, Miranda RC, Grau JW. Engaging pain fibers after a spinal cord injury fosters hemorrhage and expands the area of secondary injury. Exp Neurol. 2019;311:115\u201324. <a href=\"https:\/\/doi.org\/10.1016\/j.expneurol.2018.09.018\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/j.expneurol.2018.09.018\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.expneurol.2018.09.018<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 41\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Engaging%20pain%20fibers%20after%20a%20spinal%20cord%20injury%20fosters%20hemorrhage%20and%20expands%20the%20area%20of%20secondary%20injury&amp;journal=Exp%20Neurol&amp;doi=10.1016%2Fj.expneurol.2018.09.018&amp;volume=311&amp;pages=115-24&amp;publication_year=2019&amp;author=Turtle%2CJD&amp;author=Henwood%2CMK&amp;author=Strain%2CMM&amp;author=Huang%2CYJ&amp;author=Miranda%2CRC&amp;author=Grau%2CJW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"42.\">\n<p class=\"c-article-references__text\" id=\"ref-CR42\">Ahuja CS, Wilson JR, Nori S, Kotter MRN, Druschel C, Curt A, et al. Traumatic spinal cord injury. Nat Rev Dis Primers. 2017;3:17018. <a href=\"https:\/\/doi.org\/10.1038\/nrdp.2017.18\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1038\/nrdp.2017.18\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1038\/nrdp.2017.18<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 42\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Traumatic%20spinal%20cord%20injury&amp;journal=Nat%20Rev%20Dis%20Primers&amp;doi=10.1038%2Fnrdp.2017.18&amp;volume=3&amp;publication_year=2017&amp;author=Ahuja%2CCS&amp;author=Wilson%2CJR&amp;author=Nori%2CS&amp;author=Kotter%2CMRN&amp;author=Druschel%2CC&amp;author=Curt%2CA&amp;author=Fehlings%2CMG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"43.\">\n<p class=\"c-article-references__text\" id=\"ref-CR43\">Kroner A, Greenhalgh AD, Zarruk JG, Passos Dos Santos R, Gaestel M, David S. TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord. Neuron. 2014;83:1098\u2013116. <a href=\"https:\/\/doi.org\/10.1016\/j.neuron.2014.07.027\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/j.neuron.2014.07.027\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.neuron.2014.07.027<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 43\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=TNF%20and%20increased%20intracellular%20iron%20alter%20macrophage%20polarization%20to%20a%20detrimental%20M1%20phenotype%20in%20the%20injured%20spinal%20cord&amp;journal=Neuron&amp;doi=10.1016%2Fj.neuron.2014.07.027&amp;volume=83&amp;pages=1098-116&amp;publication_year=2014&amp;author=Kroner%2CA&amp;author=Greenhalgh%2CAD&amp;author=Zarruk%2CJG&amp;author=Passos%20Dos%20Santos%2CR&amp;author=Gaestel%2CM&amp;author=David%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"44.\">\n<p class=\"c-article-references__text\" id=\"ref-CR44\">Einwachter H, Heiseke A, Schlitzer A, Gasteiger G, Adler H, Voehringer D, et al. The innate immune response to infection induces Erythropoietin-dependent replenishment of the dendritic cell compartment. Front Immunol. 2020;11:1627. <a href=\"https:\/\/doi.org\/10.3389\/fimmu.2020.01627\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3389\/fimmu.2020.01627\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3389\/fimmu.2020.01627<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 44\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20innate%20immune%20response%20to%20infection%20induces%20Erythropoietin-dependent%20replenishment%20of%20the%20dendritic%20cell%20compartment&amp;journal=Front%20Immunol&amp;doi=10.3389%2Ffimmu.2020.01627&amp;volume=11&amp;publication_year=2020&amp;author=Einwachter%2CH&amp;author=Heiseke%2CA&amp;author=Schlitzer%2CA&amp;author=Gasteiger%2CG&amp;author=Adler%2CH&amp;author=Voehringer%2CD&amp;author=Manz%2CMG&amp;author=Ruzsics%2CZ&amp;author=Dolken%2CL&amp;author=Koszinowski%2CUH&amp;author=Sparwasser%2CT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"45.\">\n<p class=\"c-article-references__text\" id=\"ref-CR45\">David S, Kroner A. Repertoire of microglial and macrophage responses after spinal cord injury. Nat Rev Neurosci. 2011;12:388\u201399. <a href=\"https:\/\/doi.org\/10.1038\/nrn3053\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1038\/nrn3053\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1038\/nrn3053<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 45\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Repertoire%20of%20microglial%20and%20macrophage%20responses%20after%20spinal%20cord%20injury&amp;journal=Nat%20Rev%20Neurosci&amp;doi=10.1038%2Fnrn3053&amp;volume=12&amp;pages=388-99&amp;publication_year=2011&amp;author=David%2CS&amp;author=Kroner%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"46.\">\n<p class=\"c-article-references__text\" id=\"ref-CR46\">Timmins GS, Davies MJ, Song DX, Muller-Eberhard U. EPR studies on the effects of complexation of heme by hemopexin upon its reactions with organic peroxides. Free Radic Res. 1995;23:559\u201369. <a href=\"https:\/\/doi.org\/10.3109\/10715769509065277\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3109\/10715769509065277\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3109\/10715769509065277<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 46\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=EPR%20studies%20on%20the%20effects%20of%20complexation%20of%20heme%20by%20hemopexin%20upon%20its%20reactions%20with%20organic%20peroxides&amp;journal=Free%20Radic%20Res&amp;doi=10.3109%2F10715769509065277&amp;volume=23&amp;pages=559-69&amp;publication_year=1995&amp;author=Timmins%2CGS&amp;author=Davies%2CMJ&amp;author=Song%2CDX&amp;author=Muller-Eberhard%2CU\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"47.\">\n<p class=\"c-article-references__text\" id=\"ref-CR47\">Stephen R, Robinson TND, Ralf, Dringen, Glenda M, Bishop. Hemin toxicity: a preventable source of brain damage following hemorrhagic stroke. Redox Rep. 2013;228\u201335. <a href=\"https:\/\/doi.org\/10.1179\/135100009X12525712409931\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1179\/135100009X12525712409931\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1179\/135100009X12525712409931<\/a>.<\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"48.\">\n<p class=\"c-article-references__text\" id=\"ref-CR48\">Smith JMGaA. Antioxidant protection by haemopexin of haem-stimulated lipid peroxidation. Biochem J. 1988;861\u20135. <a href=\"https:\/\/doi.org\/10.1042\/bj2560861\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1042\/bj2560861\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1042\/bj2560861<\/a>.<\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"49.\">\n<p class=\"c-article-references__text\" id=\"ref-CR49\">Styliani H, Vincent RWG, Nurith Shaklai JMS, Ursula Muller-Eberhard. The influence of heme-binding proteins in heme-catalyzed oxidations. Arch Biochem Biophys. 1988;265:539\u201350.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 49\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20influence%20of%20heme-binding%20proteins%20in%20heme-catalyzed%20oxidations&amp;journal=Arch%20Biochem%20Biophys&amp;volume=265&amp;pages=539-50&amp;publication_year=1988&amp;author=Styliani%2CH&amp;author=Vincent%2CRWG&amp;author=Nurith%20Shaklai%2CJMS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"50.\">\n<p class=\"c-article-references__text\" id=\"ref-CR50\">Li RC, Saleem S, Zhen G, Cao W, Zhuang H, Lee J, et al. Heme-hemopexin complex attenuates neuronal cell death and stroke damage. J Cereb Blood Flow Metab. 2009;29(5):953\u201364. <a href=\"https:\/\/doi.org\/10.1038\/jcbfm.2009.19\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1038\/jcbfm.2009.19\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1038\/jcbfm.2009.19<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 50\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Heme-hemopexin%20complex%20attenuates%20neuronal%20cell%20death%20and%20stroke%20damage&amp;journal=J%20Cereb%20Blood%20Flow%20Metab&amp;doi=10.1038%2Fjcbfm.2009.19&amp;volume=29&amp;issue=5&amp;pages=953-64&amp;publication_year=2009&amp;author=Li%2CRC&amp;author=Saleem%2CS&amp;author=Zhen%2CG&amp;author=Cao%2CW&amp;author=Zhuang%2CH&amp;author=Lee%2CJ&amp;author=Smith%2CA&amp;author=Altruda%2CF&amp;author=Tolosano%2CE&amp;author=Dore%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"51.\">\n<p class=\"c-article-references__text\" id=\"ref-CR51\">Tolosano E, Patrucco HE, Camaschella E, Navone C, Silengo R, Altruda L. F. Defective recovery and severe renal damage after acute hemolysis in hemopexin-deficient mice blood. 1999.<\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"52.\">\n<p class=\"c-article-references__text\" id=\"ref-CR52\">Lim YK, Jenner A, Ali AB, Wang Y, Hsu SI, Chong SM, et al. Haptoglobin reduces renal oxidative DNA and tissue damage during phenylhydrazine-induced hemolysis. Kidney Int. 2000;58:1033\u201344. <a href=\"https:\/\/doi.org\/10.1046\/j.1523-1755.2000.00261.x\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1046\/j.1523-1755.2000.00261.x\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1046\/j.1523-1755.2000.00261.x<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 52\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Haptoglobin%20reduces%20renal%20oxidative%20DNA%20and%20tissue%20damage%20during%20phenylhydrazine-induced%20hemolysis&amp;journal=Kidney%20Int&amp;doi=10.1046%2Fj.1523-1755.2000.00261.x&amp;volume=58&amp;pages=1033-44&amp;publication_year=2000&amp;author=Lim%2CYK&amp;author=Jenner%2CA&amp;author=Ali%2CAB&amp;author=Wang%2CY&amp;author=Hsu%2CSI&amp;author=Chong%2CSM&amp;author=Baumman%2CH&amp;author=Halliwell%2CB&amp;author=Lim%2CSK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"53.\">\n<p class=\"c-article-references__text\" id=\"ref-CR53\">Yalamanoglu A, Deuel JW, Hunt RC, Baek JH, Hassell K, Redinius K, Irwin DC, Schaer DJ, Buehler PW. Depletion of haptoglobin and hemopexin promote hemoglobin-mediated lipoprotein oxidation in sickle cell disease. Am J Physiol Lung Cell Mol Physiol. 2018;315:L765\u201374. <a href=\"https:\/\/doi.org\/10.1152\/ajplung.00269.2018\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1152\/ajplung.00269.2018\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1152\/ajplung.00269.2018<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 53\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Depletion%20of%20haptoglobin%20and%20hemopexin%20promote%20hemoglobin-mediated%20lipoprotein%20oxidation%20in%20sickle%20cell%20disease&amp;journal=Am%20J%20Physiol%20Lung%20Cell%20Mol%20Physiol&amp;doi=10.1152%2Fajplung.00269.2018&amp;volume=315&amp;pages=L765-74&amp;publication_year=2018&amp;author=Yalamanoglu%2CA&amp;author=Deuel%2CJW&amp;author=Hunt%2CRC&amp;author=Baek%2CJH&amp;author=Hassell%2CK&amp;author=Redinius%2CK&amp;author=Irwin%2CDC&amp;author=Schaer%2CDJ&amp;author=Buehler%2CPW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"54.\">\n<p class=\"c-article-references__text\" id=\"ref-CR54\">Chen-Roetling J, Li Y, Cao Y, Yan Z, Lu X, Regan RF. Effect of hemopexin treatment on outcome after intracerebral hemorrhage in mice. Brain Res. 2021;1765:147507. <a href=\"https:\/\/doi.org\/10.1016\/j.brainres.2021.147507\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/j.brainres.2021.147507\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.brainres.2021.147507<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 54\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Effect%20of%20hemopexin%20treatment%20on%20outcome%20after%20intracerebral%20hemorrhage%20in%20mice&amp;journal=Brain%20Res&amp;doi=10.1016%2Fj.brainres.2021.147507&amp;volume=1765&amp;publication_year=2021&amp;author=Chen-Roetling%2CJ&amp;author=Li%2CY&amp;author=Cao%2CY&amp;author=Yan%2CZ&amp;author=Lu%2CX&amp;author=Regan%2CRF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"55.\">\n<p class=\"c-article-references__text\" id=\"ref-CR55\">Galea I, Bandyopadhyay S, Bulters D, Humar R, Hugelshofer M, Schaer DJ, et al. Haptoglobin treatment for aneurysmal subarachnoid hemorrhage: review and expert consensus on clinical translation. Stroke. 2023;54:1930\u201342. <a href=\"https:\/\/doi.org\/10.1161\/STROKEAHA.123.040205\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1161\/STROKEAHA.123.040205\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1161\/STROKEAHA.123.040205<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 55\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Haptoglobin%20treatment%20for%20aneurysmal%20subarachnoid%20hemorrhage%3A%20review%20and%20expert%20consensus%20on%20clinical%20translation&amp;journal=Stroke&amp;doi=10.1161%2FSTROKEAHA.123.040205&amp;volume=54&amp;pages=1930-42&amp;publication_year=2023&amp;author=Galea%2CI&amp;author=Bandyopadhyay%2CS&amp;author=Bulters%2CD&amp;author=Humar%2CR&amp;author=Hugelshofer%2CM&amp;author=Schaer%2CDJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"56.\">\n<p class=\"c-article-references__text\" id=\"ref-CR56\">Han D, Yu Z, Liu W, Yin D, Pu Y, Feng J, et al. Plasma hemopexin ameliorates murine spinal cord injury by switching microglia from the M1 state to the M2 state. Cell Death Dis. 2018;9:181. <a href=\"https:\/\/doi.org\/10.1038\/s41419-017-0236-8\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1038\/s41419-017-0236-8\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1038\/s41419-017-0236-8<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 56\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Plasma%20hemopexin%20ameliorates%20murine%20spinal%20cord%20injury%20by%20switching%20microglia%20from%20the%20M1%20state%20to%20the%20M2%20state&amp;journal=Cell%20Death%20Dis&amp;doi=10.1038%2Fs41419-017-0236-8&amp;volume=9&amp;publication_year=2018&amp;author=Han%2CD&amp;author=Yu%2CZ&amp;author=Liu%2CW&amp;author=Yin%2CD&amp;author=Pu%2CY&amp;author=Feng%2CJ&amp;author=Yuan%2CY&amp;author=Huang%2CA&amp;author=Cao%2CL&amp;author=He%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"57.\">\n<p class=\"c-article-references__text\" id=\"ref-CR57\">Jaeschke A, Hui DY. LDL receptor-related protein 1 and its interacting partners in tissue homeostasis. Curr Opin Lipidol. 2021;32:301\u20137. <a href=\"https:\/\/doi.org\/10.1097\/MOL.0000000000000776\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1097\/MOL.0000000000000776\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1097\/MOL.0000000000000776<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 57\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=LDL%20receptor-related%20protein%201%20and%20its%20interacting%20partners%20in%20tissue%20homeostasis&amp;journal=Curr%20Opin%20Lipidol&amp;doi=10.1097%2FMOL.0000000000000776&amp;volume=32&amp;pages=301-7&amp;publication_year=2021&amp;author=Jaeschke%2CA&amp;author=Hui%2CDY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"58.\">\n<p class=\"c-article-references__text\" id=\"ref-CR58\">Dong B, Cai M, Fang Z, Wei H, Zhu F, Li G, et al. Hemopexin induces neuroprotection in the rat subjected to focal cerebral ischemia. BMC Neurosci. 2013;14:58. <a href=\"https:\/\/doi.org\/10.1186\/1471-2202-14-58\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1186\/1471-2202-14-58\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1186\/1471-2202-14-58<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 58\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Hemopexin%20induces%20neuroprotection%20in%20the%20rat%20subjected%20to%20focal%20cerebral%20ischemia&amp;journal=BMC%20Neurosci&amp;doi=10.1186%2F1471-2202-14-58&amp;volume=14&amp;publication_year=2013&amp;author=Dong%2CB&amp;author=Cai%2CM&amp;author=Fang%2CZ&amp;author=Wei%2CH&amp;author=Zhu%2CF&amp;author=Li%2CG&amp;author=Dong%2CH&amp;author=Xiong%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"59.\">\n<p class=\"c-article-references__text\" id=\"ref-CR59\">Karnup S, Hashimoto M, Cho KJ, Beckel J, de Groat W, Yoshimura N. Sexual dimorphism of spinal neural circuits controlling the mouse external urethral sphincter with and without spinal cord injury. J Comp Neurol. 2024;532:e25658. <a href=\"https:\/\/doi.org\/10.1002\/cne.25658\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1002\/cne.25658\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1002\/cne.25658<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 59\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Sexual%20dimorphism%20of%20spinal%20neural%20circuits%20controlling%20the%20mouse%20external%20urethral%20sphincter%20with%20and%20without%20spinal%20cord%20injury&amp;journal=J%20Comp%20Neurol&amp;doi=10.1002%2Fcne.25658&amp;volume=532&amp;publication_year=2024&amp;author=Karnup%2CS&amp;author=Hashimoto%2CM&amp;author=Cho%2CKJ&amp;author=Beckel%2CJ&amp;author=Groat%2CW&amp;author=Yoshimura%2CN\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"60.\">\n<p class=\"c-article-references__text\" id=\"ref-CR60\">Ide S, Ide K, Abe K, Kobayashi Y, Kitai H, McKey J, et al. Sex differences in resilience to ferroptosis underlie sexual dimorphism in kidney injury and repair. Cell Rep. 2022;41(6):111610. <a href=\"https:\/\/doi.org\/10.1016\/j.celrep.2022.111610\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/j.celrep.2022.111610\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.celrep.2022.111610<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 60\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Sex%20differences%20in%20resilience%20to%20ferroptosis%20underlie%20sexual%20dimorphism%20in%20kidney%20injury%20and%20repair&amp;journal=Cell%20Rep&amp;doi=10.1016%2Fj.celrep.2022.111610&amp;volume=41&amp;issue=6&amp;publication_year=2022&amp;author=Ide%2CS&amp;author=Ide%2CK&amp;author=Abe%2CK&amp;author=Kobayashi%2CY&amp;author=Kitai%2CH&amp;author=McKey%2CJ&amp;author=Strausser%2CSA&amp;author=O%E2%80%99Brien%2CLL&amp;author=Tata%2CA&amp;author=Tata%2CPR&amp;author=Souma%2CT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"61.\">\n<p class=\"c-article-references__text\" id=\"ref-CR61\">Tao H, Dar HY, Tian C, Banerjee S, Glazer ES, Srinivasan S, et al. Differences in hepatocellular iron metabolism underlie sexual dimorphism in hepatocyte ferroptosis. Redox Biol. 2023;67:102892. <a href=\"https:\/\/doi.org\/10.1016\/j.redox.2023.102892\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/j.redox.2023.102892\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.redox.2023.102892<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 61\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Differences%20in%20hepatocellular%20iron%20metabolism%20underlie%20sexual%20dimorphism%20in%20hepatocyte%20ferroptosis&amp;journal=Redox%20Biol&amp;doi=10.1016%2Fj.redox.2023.102892&amp;volume=67&amp;publication_year=2023&amp;author=Tao%2CH&amp;author=Dar%2CHY&amp;author=Tian%2CC&amp;author=Banerjee%2CS&amp;author=Glazer%2CES&amp;author=Srinivasan%2CS&amp;author=Zhu%2CL&amp;author=Pacifici%2CR&amp;author=He%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"62.\">\n<p class=\"c-article-references__text\" id=\"ref-CR62\">Toth B, Yokoyama Y, Kuebler JF, Schwacha MG, Rue LW 3rd, Bland KI, Chaudry IH. Sex differences in hepatic Heme Oxygenase expression and activity following trauma and hemorrhagic shock. Arch Surg. 2003;138:1375\u201382. <a href=\"https:\/\/doi.org\/10.1001\/archsurg.138.12.1375\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1001\/archsurg.138.12.1375\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1001\/archsurg.138.12.1375<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 62\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Sex%20differences%20in%20hepatic%20Heme%20Oxygenase%20expression%20and%20activity%20following%20trauma%20and%20hemorrhagic%20shock&amp;journal=Arch%20Surg&amp;doi=10.1001%2Farchsurg.138.12.1375&amp;volume=138&amp;pages=1375-82&amp;publication_year=2003&amp;author=Toth%2CB&amp;author=Yokoyama%2CY&amp;author=Kuebler%2CJF&amp;author=Schwacha%2CMG&amp;author=Rue%2CLW&amp;author=Bland%2CKI&amp;author=Chaudry%2CIH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"63.\">\n<p class=\"c-article-references__text\" id=\"ref-CR63\">Kapojos JJ, van den Berg A, van Goor H, te Loo MW, Poelstra K, Borghuis T, Bakker WW. Production of hemopexin by TNF-alpha stimulated human mesangial cells. Kidney Int. 2003;63:1681\u20136. <a href=\"https:\/\/doi.org\/10.1046\/j.1523-1755.2003.00907.x\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1046\/j.1523-1755.2003.00907.x\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1046\/j.1523-1755.2003.00907.x<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 63\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Production%20of%20hemopexin%20by%20TNF-alpha%20stimulated%20human%20mesangial%20cells&amp;journal=Kidney%20Int&amp;doi=10.1046%2Fj.1523-1755.2003.00907.x&amp;volume=63&amp;pages=1681-6&amp;publication_year=2003&amp;author=Kapojos%2CJJ&amp;author=Berg%2CA&amp;author=Goor%2CH&amp;author=Loo%2CMW&amp;author=Poelstra%2CK&amp;author=Borghuis%2CT&amp;author=Bakker%2CWW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"64.\">\n<p class=\"c-article-references__text\" id=\"ref-CR64\">Tolosano E, Altruda F. Hemopexin: structure, function, and regulation. DNA Cell Biol. 2002;21:297\u2013306. <a href=\"https:\/\/doi.org\/10.1089\/104454902753759717\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1089\/104454902753759717\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1089\/104454902753759717<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 64\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Hemopexin%3A%20structure%2C%20function%2C%20and%20regulation&amp;journal=DNA%20Cell%20Biol&amp;doi=10.1089%2F104454902753759717&amp;volume=21&amp;pages=297-306&amp;publication_year=2002&amp;author=Tolosano%2CE&amp;author=Altruda%2CF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"65.\">\n<p class=\"c-article-references__text\" id=\"ref-CR65\">Novrup HG, Bracchi-Ricard V, Ellman DG, Ricard J, Jain A, Runko E, Lyck L, Yli-Karjanmaa M, Szymkowski DE, Pearse DD, Lambertsen KL, et al. Central but not systemic administration of XPro1595 is therapeutic following moderate spinal cord injury in mice. J Neuroinflammation. 2014;11:159. <a href=\"https:\/\/doi.org\/10.1186\/s12974-014-0159-6\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1186\/s12974-014-0159-6\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1186\/s12974-014-0159-6<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 65\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Central%20but%20not%20systemic%20administration%20of%20XPro1595%20is%20therapeutic%20following%20moderate%20spinal%20cord%20injury%20in%20mice&amp;journal=J%20Neuroinflammation&amp;doi=10.1186%2Fs12974-014-0159-6&amp;volume=11&amp;publication_year=2014&amp;author=Novrup%2CHG&amp;author=Bracchi-Ricard%2CV&amp;author=Ellman%2CDG&amp;author=Ricard%2CJ&amp;author=Jain%2CA&amp;author=Runko%2CE&amp;author=Lyck%2CL&amp;author=Yli-Karjanmaa%2CM&amp;author=Szymkowski%2CDE&amp;author=Pearse%2CDD&amp;author=Lambertsen%2CKL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"66.\">\n<p class=\"c-article-references__text\" id=\"ref-CR66\">Gerald MJ, Bracchi-Ricard V, Ricard J, Fischer R, Nandakumar B, Blumenthal GH, et al. Continuous infusion of an agonist of the tumor necrosis factor receptor 2 in the spinal cord improves recovery after traumatic contusive injury. CNS Neurosci Ther. 2019;25:884\u201393. <a href=\"https:\/\/doi.org\/10.1111\/cns.13125\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1111\/cns.13125\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1111\/cns.13125<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 66\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Continuous%20infusion%20of%20an%20agonist%20of%20the%20tumor%20necrosis%20factor%20receptor%202%20in%20the%20spinal%20cord%20improves%20recovery%20after%20traumatic%20contusive%20injury&amp;journal=CNS%20Neurosci%20Ther&amp;doi=10.1111%2Fcns.13125&amp;volume=25&amp;pages=884-93&amp;publication_year=2019&amp;author=Gerald%2CMJ&amp;author=Bracchi-Ricard%2CV&amp;author=Ricard%2CJ&amp;author=Fischer%2CR&amp;author=Nandakumar%2CB&amp;author=Blumenthal%2CGH&amp;author=Williams%2CR&amp;author=Kontermann%2CRE&amp;author=Pfizenmaier%2CK&amp;author=Moxon%2CKA&amp;author=Bethea%2CJR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"67.\">\n<p class=\"c-article-references__text\" id=\"ref-CR67\">Faulkner JR, Herrmann JE, Woo MJ, Tansey KE, Doan NB, Sofroniew MV. Reactive astrocytes protect tissue and preserve function after spinal cord injury. J Neurosci. 2004;24:2143\u201355. <a href=\"https:\/\/doi.org\/10.1523\/JNEUROSCI.3547-03.2004\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1523\/JNEUROSCI.3547-03.2004\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1523\/JNEUROSCI.3547-03.2004<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 67\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Reactive%20astrocytes%20protect%20tissue%20and%20preserve%20function%20after%20spinal%20cord%20injury&amp;journal=J%20Neurosci&amp;doi=10.1523%2FJNEUROSCI.3547-03.2004&amp;volume=24&amp;pages=2143-55&amp;publication_year=2004&amp;author=Faulkner%2CJR&amp;author=Herrmann%2CJE&amp;author=Woo%2CMJ&amp;author=Tansey%2CKE&amp;author=Doan%2CNB&amp;author=Sofroniew%2CMV\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"68.\">\n<p class=\"c-article-references__text\" id=\"ref-CR68\">Neirinckx V, Coste C, Franzen R, Gothot A, Rogister B, Wislet S. Neutrophil contribution to spinal cord injury and repair. J Neuroinflammation. 2014;11:150. <a href=\"https:\/\/doi.org\/10.1186\/s12974-014-0150-2\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1186\/s12974-014-0150-2\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1186\/s12974-014-0150-2<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 68\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Neutrophil%20contribution%20to%20spinal%20cord%20injury%20and%20repair&amp;journal=J%20Neuroinflammation&amp;doi=10.1186%2Fs12974-014-0150-2&amp;volume=11&amp;publication_year=2014&amp;author=Neirinckx%2CV&amp;author=Coste%2CC&amp;author=Franzen%2CR&amp;author=Gothot%2CA&amp;author=Rogister%2CB&amp;author=Wislet%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"69.\">\n<p class=\"c-article-references__text\" id=\"ref-CR69\">Stirling DP, Liu S, Kubes P, Yong VW. Depletion of Ly6G\/Gr-1 leukocytes after spinal cord injury in mice alters wound healing and worsens neurological outcome. J Neurosci. 2009;29:753\u201364. <\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 69\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Depletion%20of%20Ly6G%2FGr-1%20leukocytes%20after%20spinal%20cord%20injury%20in%20mice%20alters%20wound%20healing%20and%20worsens%20neurological%20outcome&amp;journal=J%20Neurosci&amp;doi=10.1523%2FJNEUROSCI.4918-08.2009&amp;volume=29&amp;pages=753-64&amp;publication_year=2009&amp;author=Stirling%2CDP&amp;author=Liu%2CS&amp;author=Kubes%2CP&amp;author=Yong%2CVW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"70.\">\n<p class=\"c-article-references__text\" id=\"ref-CR70\">Pacheco MR, Tran AV, Bradley ML, Leal-Garcia ME, Ozturgut M, Barnett EA, Chakka VV, Devaraj S, Kirchhoff M, Mulamba T, Thomas K, et al. Mature neutrophils promotelong-term functional recovery after spinal cord injury in a sex-dependent manner.BioRxiv. 2025;202520022025640256.\u00a0<a href=\"https:\/\/doi.org\/10.1101\/2025.02.25.640256\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1101\/2025.02.25.640256\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1101\/2025.02.25.640256<\/a>.<\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"71.\">\n<p class=\"c-article-references__text\" id=\"ref-CR71\">Pratico D, Uryu K, Leight S, Trojanoswki JQ, Lee VM. Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis. J Neurosci. 2001;21:4183\u20137.<\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"72.\">\n<p class=\"c-article-references__text\" id=\"ref-CR72\">Castellani RJ, Perry G, Siedlak SL, Nunomura A, Shimohama S, Zhang J, et al.Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem lewy bodies in humans. Neurosci Lett. 2002;319:25\u20138. <a href=\"https:\/\/doi.org\/10.1016\/s0304-3940(01)02514-9\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/s0304-3940(01)02514-9\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/s0304-3940(01)02514-9<\/a>.<\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"73.\">\n<p class=\"c-article-references__text\" id=\"ref-CR73\">Ma T, Du J, Zhang Y, Wang Y, Wang B, Zhang T. Gpx4-independent ferroptosis-a new strategy in disease\u2019s therapy. Cell Death Discov. 2022;8:434. <a href=\"https:\/\/doi.org\/10.1038\/s41420-022-01212-0\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1038\/s41420-022-01212-0\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1038\/s41420-022-01212-0<\/a>.<\/p>\n<\/li>\n<li class=\"c-article-references__item js-c-reading-companion-references-item\" data-counter=\"74.\">\n<p class=\"c-article-references__text\" id=\"ref-CR74\">Basso DM, Fisher LC, Anderson AJ, Jakeman LB, McTigue DM, and Popovich PG. Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains. J Neurotrauma 23, 2006;635\u2013659.\u00a0<a href=\"https:\/\/doi.org\/10.1089\/neu.2006.23.635\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1089\/neu.2006.23.635\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1089\/neu.2006.23.635<\/a>.<\/p>\n<\/li>\n","protected":false},"excerpt":{"rendered":"Sekhon LH, Fehlings MG. Epidemiology, demographics, and pathophysiology of acute spinal cord injury. Spine (Phila Pa 1976). 2001;26:S2\u201312.&hellip;\n","protected":false},"author":2,"featured_media":192372,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[78],"tags":[18,135,107154,12450,19,5533,17,1280,3267,5801,68597,107155,19323],"class_list":{"0":"post-192371","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-eire","9":"tag-health","10":"tag-hemopexin","11":"tag-hemorrhage","12":"tag-ie","13":"tag-immunology","14":"tag-ireland","15":"tag-neurobiology","16":"tag-neurology","17":"tag-neurosciences","18":"tag-neutrophils","19":"tag-secondary-damage","20":"tag-spinal-cord-injury"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@ie\/115587207869604312","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts\/192371","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/comments?post=192371"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts\/192371\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/media\/192372"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/media?parent=192371"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/categories?post=192371"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/tags?post=192371"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}