The inquest heard Antonio had Downs Syndrome, attention deficit hyperactivity disorder and autism, and was also born with Tetralogy of Fallot, a congenital heart defect.<\/p>\n
Mr Longstaff was told the teenager had been admitted to LGI to undergo heart surgery on 30 September after which he was sedated “by a constant Propofol infusion and occasional bolus doses”.<\/p>\n
From 4 October, Antonio developed a “persistent and increasing fever” and he was noted to have a Stage 1 acute kidney injury on 5 October.<\/p>\n
On 6 October, concern was raised that his deterioration might be due to Propofol-Related Infusion Syndrome and his Propofol was stopped and replaced with fentanyl.<\/p>\n
He died the following day after he went into cardiac arrest.<\/p>\n
Recording a narrative conclusion, Mr Longstaff said Antonio had died “from the effects of receiving a continuous Propofol infusion of 5,634 milligrams plus additional bolus doses over a period of 121 hours, while in post-operative sedation on the Paediatric Intensive Care Unit (PICU)”.<\/p>\n
The inquest heard the trust had since devised and implemented new guidelines around the use of Propofol for “short term sedation in children and young people on PICU”.<\/p>\n