{"id":31250,"date":"2025-08-29T18:04:06","date_gmt":"2025-08-29T18:04:06","guid":{"rendered":"https:\/\/www.europesays.com\/ie\/31250\/"},"modified":"2025-08-29T18:04:06","modified_gmt":"2025-08-29T18:04:06","slug":"the-seven-shifts-needed-to-accelerate-longevity-science","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/ie\/31250\/","title":{"rendered":"The seven shifts needed to accelerate longevity science"},"content":{"rendered":"<p> <strong>McKinsey Health Institute report calls for change to facilitate the development of biomedical interventions targeting the aging process.<\/strong> <\/p>\n<p>A new report from the <a href=\"https:\/\/www.mckinsey.com\/mhi\/overview\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">McKinsey Health Institute<\/a> (MHI) was published today, focused on how to accelerate progress in healthspan science to the benefit of society at large. Entitled,\u00a0 <a href=\"https:\/\/www.mckinsey.com\/mhi\/our-insights\/healthspan-science-may-enable-healthier-lives-for-all\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Healthspan science may enable healthier lives for all<\/a>, the report identifies seven key \u201cshifts\u201d that would help create the conditions to allow longevity biotech to flourish.<\/p>\n<p>From defining the field and improving our fundamental understanding of aging to achieving consensus on biomarkers and establishing clear regulatory pathways, the report\u2019s authors call for greater investment and leadership in longevity to enable the benefits of aging-focused interventions to be realized.<\/p>\n<p><strong>Longevity.Technology: A non-profit-generating institute within consulting giant McKinsey, MHI is founded on the belief that humanity could add up to 45 billion years of higher-quality life in the next decade. The group focuses on historically under-invested areas of health to convene leaders, advance research, produce open-access data and tools, promote innovation and investment, and drive collaboration for systemic change in population health. And healthspan is squarely in its sights. To learn more, we sat down with Lars Hartenstein, director of healthy longevity at MHI, who presented the new report at the <a href=\"https:\/\/agingpharma.org\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Aging Research and Drug Discovery conference<\/a> (ARDD) in Copenhagen this week.<\/strong><\/p>\n<p> <img fetchpriority=\"high\" width=\"1024\" height=\"683\" alt=\"\" nitro-lazy-src=\"https:\/\/cdn-ilclkjd.nitrocdn.com\/gGMFLmxRxYtlfrobExXMvPeqSnTPOgve\/assets\/images\/optimized\/rev-0a10ac6\/longevity.technology\/wp-content\/uploads\/2025\/08\/Lars-Hartenstein_1985_headshot_crop-1-1024x683.jpg\" class=\"wp-image-64387 nitro-lazy\" decoding=\"async\" nitro-lazy-empty=\"\" id=\"NDc4NzoyNzY=-1\" src=\"data:image\/svg+xml;nitro-empty-id=NDc4NzoyNzY=-1;base64,PHN2ZyB2aWV3Qm94PSIwIDAgMTAyNCA2ODMiIHdpZHRoPSIxMDI0IiBoZWlnaHQ9IjY4MyIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48L3N2Zz4=\"\/>Lars Hartenstein is director of healthy longevity at the McKinsey Health Institute. <\/p>\n<p>While investment in longevity biotech continues to grow, the sector still lags far behind that of other areas of health such as oncology. And this is exactly what makes it interesting to MHI, says Hartenstein.<\/p>\n<p>\u201cThe field is at this \u2018in-between\u2019 point \u2013 it\u2019s nascent and emerging, not yet fully investable at scale,\u201d he explains. \u201cWe\u2019ve been looking at healthy longevity from the very beginning. As the field has matured, our interest has grown but this is the first time we\u2019ve examined it through the lens of biomedical innovation.\u201d \u00a0<\/p>\n<p>Addressing the biology of aging has enormous theoretical potential to combat age-related diseases, which Hartenstein says account for about a third of the global disease burden.<\/p>\n<p>  <a href=\"https:\/\/www.mckinsey.com\/mhi\/our-insights\/healthspan-science-may-enable-healthier-lives-for-all\" target=\"_blank\" rel=\" noreferrer noopener nofollow\"><img loading=\"lazy\" width=\"240\" height=\"300\" alt=\"\" nitro-lazy-src=\"https:\/\/cdn-ilclkjd.nitrocdn.com\/gGMFLmxRxYtlfrobExXMvPeqSnTPOgve\/assets\/images\/optimized\/rev-0a10ac6\/longevity.technology\/wp-content\/uploads\/2025\/08\/MHI-healthspan-science-report-cover-2-240x300.jpg\" class=\"wp-image-64404 nitro-lazy\" decoding=\"async\" nitro-lazy-empty=\"\" id=\"NDgwMzozNzg=-1\" src=\"data:image\/svg+xml;nitro-empty-id=NDgwMzozNzg=-1;base64,PHN2ZyB2aWV3Qm94PSIwIDAgMjQwIDMwMCIgd2lkdGg9IjI0MCIgaGVpZ2h0PSIzMDAiIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyI+PC9zdmc+\"\/><\/a> <\/p>\n<p>\u201cThe economic potential is huge: using our Prioritizing Health model, we estimate that tackling just half of this burden could add about $2 trillion to global GDP,\u201d he says. \u201cSo it\u2019s an area of massive potential. The idea of the paper is to synthesize where things stand \u2013 the challenges, the opportunities for acceleration \u2013 and to argue that real progress will require broader engagement. More people need to pay attention to this field than currently are.\u201d<\/p>\n<p>In the report, Hartenstein and his co-authors outline seven key shifts needed to accelerate progress in healthspan science and interventions, each representing a key challenge the field currently faces:<\/p>\n<ul class=\"wp-block-list\">\n<li><strong>1. Clear definition and perception<\/strong><\/li>\n<\/ul>\n<p>In order to foster coherence in research and public policy, the report calls for consensus on key terminology \u2013 longevity, healthspan, healthy aging, geroscience etc. \u2013 as well as the field\u2019s goals, and core concepts.<\/p>\n<p>\u201cRight now, the field lacks a consistent definition,\u201d says Hartenstein. \u201cThis makes it hard for the science-driven community to own the narrative, and leaves space for less evidence-based voices to dominate. Our suggestion is to shift the framing from \u2018lifespan\u2019 to \u2018healthspan\u2019 and align around that. In the paper, we offer a working definition \u2013 not to set a global standard, but to make sure we\u2019re clear about what we mean.\u201d<\/p>\n<ul class=\"wp-block-list\">\n<li><strong>2. Fundamental understanding of the science<\/strong><\/li>\n<\/ul>\n<p>The biology of aging is still not fully understood, and the report calls for research to be coordinated globally, prioritizing comprehensive data collection (biomarkers, multiomics, longitudinal cohorts), and utilizing new technologies to generate deeper insights.<\/p>\n<p>\u201cThere\u2019s a need for a more consolidated global agenda: connecting datasets, encouraging collaboration, and leveraging AI and machine learning to accelerate discovery,\u201d says Hartenstein. \u201cAt present, too much effort is fragmented, with data often locked behind IP considerations. There are lessons from other fields, like Alzheimer\u2019s, where global collaboration has advanced knowledge more effectively.\u201d<\/p>\n<p>The report\u2019s authors call for the development and validation of standardized, predictive biomarkers and composite scores as surrogate endpoints for clinical trials to accelerate translation and regulatory approval.<\/p>\n<p> <img loading=\"lazy\" width=\"1024\" height=\"683\" alt=\"\" nitro-lazy-src=\"https:\/\/cdn-ilclkjd.nitrocdn.com\/gGMFLmxRxYtlfrobExXMvPeqSnTPOgve\/assets\/images\/optimized\/rev-0a10ac6\/longevity.technology\/wp-content\/uploads\/2025\/08\/Lars-MHI-at-ARDD-1024x683.jpg\" class=\"wp-image-64388 nitro-lazy\" decoding=\"async\" nitro-lazy-empty=\"\" id=\"NDg1MjoyMTM=-1\" src=\"data:image\/svg+xml;nitro-empty-id=NDg1MjoyMTM=-1;base64,PHN2ZyB2aWV3Qm94PSIwIDAgMTAyNCA2ODMiIHdpZHRoPSIxMDI0IiBoZWlnaHQ9IjY4MyIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIj48L3N2Zz4=\"\/>Hartenstein presented the report at ARDD in Copenhagen this week. <\/p>\n<p>\u201cThere are at least two major initiatives underway in this area, but more progress is needed,\u201d says Hartenstein. \u201cWe need consensus on diagnostics, but more importantly, surrogate endpoints that can guide clinical development. This is difficult because biomarkers need to be dynamic\u2014core measures must exist, but also be adaptable as research evolves. Achieving consensus across researchers, regulators, and governments is a real challenge.\u201d<\/p>\n<p>Accelerating clinical development is a vast and complex area, and the report addresses several key issues, including a call to improved trial design through adaptive, signal-seeking, and patient-centered approaches. It also proposes leveraging AI, data integration, and innovative preclinical models to optimize candidate discovery, and increasing cross-sector R&amp;D partnerships.<\/p>\n<p>\u201cThere is not yet a single drug on the market developed specifically to test geroscience hypotheses,\u201d says Hartenstein. \u201cMany of the drugs in later-stage pipelines were originally developed for other diseases. The field lacks the involvement of highly experienced clinical development professionals from big pharma. Some funding is coming from investors with less life-science expertise, which is positive in terms of capital flow, but this also creates challenges for rigor and direction.\u201d<\/p>\n<p>The report calls for early engagement with regulators to develop frameworks for approving interventions targeting aging, either by adapting existing therapeutic pathways or developing new ones based on functional or resilience-related endpoints.<\/p>\n<p>\u201cA clear regulatory pathway is essential to de-risk and stimulate investment,\u201d says Hartenstein. \u201cBut the field has no consensus on whether this requires new frameworks or can fit within existing ones. Either way, a clearly charted path is needed, because regulators and investors alike need to know how this kind of innovation will be evaluated.\u201d<\/p>\n<p>The report stresses the need to attract traditional life sciences investors and pharma to the longevity field by establishing clearer regulatory and commercial models, and encouraging blended finance approaches involving philanthropists, blue-chip VCs, and public funders.<\/p>\n<p>\u201cFunding currently comes disproportionately from philanthropic and high-net-worth individuals,\u201d says Hartenstein. \u201cTraditional life-science investors are less involved. We suggest blended finance approaches, where philanthropic or risk-tolerant capital helps de-risk opportunities and attract more experienced investors.\u201d<\/p>\n<ul class=\"wp-block-list\">\n<li><strong>7. Clinical practice and expertise<\/strong><\/li>\n<\/ul>\n<p>The final call made by the report is to train more clinicians and researchers in healthspan science, broaden access to evidence-based interventions, and integrate \u201chealthy longevity\u201d into mainstream and preventive healthcare.<\/p>\n<p>\u201cWhen I was in medical school, there was virtually no discussion of healthspan,\u201d reflects Hartenstein. \u201cEven today, there\u2019s a lack of expertise among clinicians, researchers, funders, and leaders in the field. The community is small\u2014you often meet the same people everywhere.\u201d<\/p>\n<p>\u201cBuilding capacity is critical. Organizations like the Healthy Longevity Medicine Society are playing a role, but more national and regional allies are needed to embed this across world regions.\u201d<\/p>\n<p> <strong>Greater acceleration is possible<\/strong> <\/p>\n<p>While Hartenstein admits that progress is currently being made in all seven areas, he believes each could accelerate significantly.<\/p>\n<p>\u201cOverall, it\u2019s a positive story \u2013 the field is advancing, conferences are growing, and attention is increasing \u2013 but we\u2019re still scratching the surface in many areas,\u201d he says. \u201cRight now, I\u2019d describe progress as Scenario A \u2013 steady but limited. In each area, there\u2019s a Scenario B with much greater acceleration potential.\u201d<\/p>\n<p>While greater investment is clearly a large part of achieving Scenario B, Hartenstein says that strong leadership and greater awareness is equally important.<\/p>\n<p>\u201cIn government and pharma especially, even modest attention and engagement could go a long way, without necessarily requiring huge investments, because there aren\u2019t yet many fully investable assets,\u201d he says. \u201cThe key question is: what kind of coalition can we form? There are historical analogs in life sciences\u2014the Human Genome Project, ITER in nuclear fusion, and others. Not all were equally successful, but they show what is possible.\u201d<\/p>\n<p>\u201cTo accelerate progress in longevity, we need coalitions that can drive pivotal trials, foster global data collaboratives, and establish public-health frameworks with authority. That would go a long way toward creating the conditions for everything else to follow.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"McKinsey Health Institute report calls for change to facilitate the development of biomedical interventions targeting the aging process.&hellip;\n","protected":false},"author":2,"featured_media":31251,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[275],"tags":[18,135,475,474,24661,19,1915,17,24662,4109,7766,24663,5],"class_list":{"0":"post-31250","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-healthcare","8":"tag-eire","9":"tag-health","10":"tag-health-care","11":"tag-healthcare","12":"tag-healthspan","13":"tag-ie","14":"tag-interview","15":"tag-ireland","16":"tag-lars-hartenstein","17":"tag-longevity","18":"tag-mckinsey","19":"tag-mckinsey-health-institute","20":"tag-news"},"share_on_mastodon":{"url":"","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts\/31250","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/comments?post=31250"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts\/31250\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/media\/31251"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/media?parent=31250"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/categories?post=31250"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/tags?post=31250"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}