<\/p>\n
This study suggests vitamin D may help rebalance how the immune system sees gut bacteria. That’s an important step toward understanding how we might restore immune tolerance in IBD.”<\/p>\n
\n
<\/p>\n
John Mark Gubatan, M.D., lead author, gastroenterologist\u00a0at\u00a0Mayo Clinic, Florida<\/p>\n
\n<\/p><\/blockquote>\n
In the study, researchers evaluated 48 people with IBD who had low\u00a0vitamin D\u00a0levels. Participants received weekly vitamin D supplements for 12 weeks. Blood and stool samples collected before and after treatment were analyzed using advanced sequencing to map interactions between immune responses and the gut microbiome.<\/p>\n
Vitamin D supplementation was associated with increased levels of immunoglobulin A (IgA), which is typically linked to protective immune responses, and decreased levels of immunoglobulin G (IgG), more often associated with inflammation. The researchers also observed changes in immune signaling pathways and increased activity of regulatory immune cells that help control inflammation.<\/p>\n
Together, these findings suggest vitamin D may help promote a more balanced, protective immune response to the gut microbiome.<\/p>\n
Vitamin D supplementation was also associated with improvements in disease activity scores and a stool-based marker of inflammation. However, the researchers emphasize the study was small and not designed to establish cause and effect.<\/p>\n
“We saw encouraging signals, but this was not a randomized trial,” Dr. Gubatan says. “These findings need to be confirmed in larger, controlled studies.”<\/p>\n
The researchers caution that patients should not change their vitamin D use without medical guidance.<\/p>\n
“Vitamin D is widely available, but dosing needs to be individualized, especially in patients with chronic inflammation,” Dr. Gubatan adds. “Patients should work with their healthcare team.”<\/p>\n
This work was supported by a grant from Doris Duke Physician Scientist Fellowship Award (Grant #2021091), Chan Zukcerberg Biohub Physician Scientist Scholar Award, and National Institutes of Health (NIH) NIDDK LRP Award (2L30 DK126220).<\/p>\n
Source:<\/p>\n
Journal reference:<\/p>\n
Gubatan, J., et al. (2026). Multi-omics reveal vitamin D regulation of immune-gut microbiome interactions and tolerogenic pathways in inflammatory bowel disease.\u00a0Cell Reports Medicine. DOI: 10.1016\/j.xcrm.2026.102703.\u00a0https:\/\/www.cell.com\/cell-reports-medicine\/fulltext\/S2666-3791(26)00120-5<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"Vitamin D\u00a0supplementation may help shape how the immune system responds to gut bacteria in people with\u00a0inflammatory bowel disease\u00a0(IBD),…\n","protected":false},"author":2,"featured_media":17657,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_share_on_mastodon":"0"},"categories":[78],"tags":[1669,5505,142,18,135,19,166,1666,46673,99,6364,17,96,6106,95182,11699],"class_list":["post-405333","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-bacteria","tag-cell","tag-chronic","tag-eire","tag-health","tag-ie","tag-immune-response","tag-immune-system","tag-immunoglobulin","tag-inflammation","tag-inflammatory-bowel-disease","tag-ireland","tag-medicine","tag-microbiome","tag-ulcerative-colitis","tag-vitamin-d"],"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@ie\/116296837109624189","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts\/405333","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/comments?post=405333"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts\/405333\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/media\/17657"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/media?parent=405333"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/categories?post=405333"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/tags?post=405333"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}