{"id":507123,"date":"2026-05-28T15:55:18","date_gmt":"2026-05-28T15:55:18","guid":{"rendered":"https:\/\/www.europesays.com\/ie\/507123\/"},"modified":"2026-05-28T15:55:18","modified_gmt":"2026-05-28T15:55:18","slug":"two-dose-nasal-spray-could-reverse-brain-aging","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/ie\/507123\/","title":{"rendered":"Two-dose nasal spray could reverse brain aging"},"content":{"rendered":"

One spray could turn back the clock.<\/p>\n

Scientists have developed a therapy that they say could reverse brain aging<\/a>, restoring memory and focus that\u2019s typically lost over time.<\/p>\n

And just two doses showed improvements in cognitive function \u2014 a notable result, as new dementia cases are projected to double over the next four decades, reaching about 1 million in 2060<\/a>.<\/p>\n

\"AA new therapy in an easy-to-use nasal spray has been developed to reverse brain aging, improving memory and focus. Rido \u2013 stock.adobe.com<\/p>\n

Researchers have long known that inflammation<\/a> plays a role in how brains age, a process known as \u201cneuroinflammaging\u201d that can interfere with memory, thinking and how the brain adapts to new situations.<\/p>\n

In a study<\/a> from researchers at Texas A&M University, two doses of a nasal spray dramatically reduced brain inflammation, restored the brain\u2019s cellular power plants and significantly improved memory in mice.<\/p>\n

The most surprising outcome of the study was that the results occurred in a matter of weeks and lasted for months.<\/p>\n

The spray uses millions of microscopic biological particles called extracellular vesicles that transport genetic material between cells.<\/p>\n

They carried microRNAs that modulate and regulate gene and signaling pathways in the brain.<\/p>\n

By sending the particles through the nose, they were able to bypass the brain\u2019s protective barrier and be delivered straight to the brain tissue.<\/p>\n

Once inside the brain, the treatment targeted cells involved with chronic inflammation that are linked to aging.<\/p>\n

The spray did more than reduce inflammation in the brain, though, by restoring brain cell energy via the mitochondria (the power plants inside cells).<\/p>\n

\"AThe spray is able to be absorbed by the brain, which then reduces inflammation that can contribute to brain aging. brizmaker \u2013 stock.adobe.com<\/p>\n

Mitochondria can be damaged by aging and inflammation, making brain cells less efficient.<\/p>\n

This restoration of the cells\u2019 energy better allowed them to process and store information.<\/p>\n

It\u2019s also not just about biological improvements, but real-world observable ones: Treated animals performed better in behavioral testing on memory and recognition tasks.<\/p>\n

They were also more successful at identifying familiar objects, recognizing new ones and detecting changes in their surroundings compared to untreated controls.<\/p>\n

The treatment could have broader uses for neurodegenerative conditions, such as dementia.<\/p>\n

\u201cAs we develop and scale this therapy, a simple, two-dose nasal spray could one day replace invasive, risky procedures or maybe even months of medication,\u201d study lead Dr. Ashok Shetty said in a press release<\/a>.<\/p>\n

The researchers are also hopeful that the treatment could potentially help stroke patients recover brain function or slow cognitive decline related to aging.<\/p>\n","protected":false},"excerpt":{"rendered":"One spray could turn back the clock. Scientists have developed a therapy that they say could reverse brain…\n","protected":false},"author":2,"featured_media":507124,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_share_on_mastodon":"0"},"categories":[274],"tags":[2429,31234,868,18,135,19,17,4109,462,14176],"class_list":["post-507123","post","type-post","status-publish","format-standard","has-post-thumbnail","category-medication","tag-aging","tag-brains","tag-dementia","tag-eire","tag-health","tag-ie","tag-ireland","tag-longevity","tag-medication","tag-study-says"],"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@ie\/116653020678826468","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts\/507123","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/comments?post=507123"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts\/507123\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/media\/507124"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/media?parent=507123"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/categories?post=507123"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/tags?post=507123"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}