{"id":530294,"date":"2026-06-11T18:34:13","date_gmt":"2026-06-11T18:34:13","guid":{"rendered":"https:\/\/www.europesays.com\/ie\/530294\/"},"modified":"2026-06-11T18:34:13","modified_gmt":"2026-06-11T18:34:13","slug":"rat-kidneys-grown-in-mice-offer-new-hope-for-transplant-patients-health","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/ie\/530294\/","title":{"rendered":"Rat kidneys grown in mice offer new hope for transplant patients | Health"},"content":{"rendered":"<p>                        <img loading=\"lazy\" decoding=\"async\" src=\"data:image\/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAQAAAADCAQAAAAe\/WZNAAAAEElEQVR42mM8U88ABowYDABAxQPltt5zqAAAAABJRU5ErkJggg==\" alt=\"image\" class=\"img-responsive lazyload full default\" width=\"1697\" height=\"1221\" data- data-\/><\/p>\n<p>(S.Yuri\/A.Isotani\/N.I.S.T via SWNS)<\/p>\n<p>                                    By Talker<\/p>\n<p class=\"wp-block-paragraph\"><strong>By Stephen Beech<\/strong><\/p>\n<p class=\"wp-block-paragraph\">Rat kidneys have been successfully grown in <a href=\"https:\/\/talker.news\/2025\/01\/28\/scientists-genetically-engineer-mice-with-two-male-parents\/\" rel=\"nofollow noopener\" target=\"_blank\">mice<\/a> \u2014 offering hope for millions of people waiting for transplants.<\/p>\n<p class=\"wp-block-paragraph\">The breakthrough provides a new way of helping to reduce growing organ donor shortages, say scientists.<\/p>\n<p class=\"wp-block-paragraph\">Researchers in Japan generated rat-derived kidneys in mice using a technique known as interspecies blastocyst complementation.<\/p>\n<p class=\"wp-block-paragraph\">They say transplantation remains the most effective treatment for end-stage kidney disease.<\/p>\n<p class=\"wp-block-paragraph\">But a severe shortage of donor organs continues to limit access for millions of patients worldwide.<\/p>\n<p class=\"wp-block-paragraph\">With demand for kidney transplants expected to reach 5 million patients by 2030 and only a fraction of that need currently being met, scientists are exploring innovative approaches to generate transplantable organs.<\/p>\n<p>                        <img loading=\"lazy\" decoding=\"async\" src=\"data:image\/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAQAAAADCAQAAAAe\/WZNAAAAEElEQVR42mM8U88ABowYDABAxQPltt5zqAAAAABJRU5ErkJggg==\" alt=\"pexels-pixabay-159483\" class=\"img-responsive lazyload full default\" width=\"1279\" height=\"834\" data- data-\/><\/p>\n<p>Photo by Pixabay via Pexels<\/p>\n<p class=\"wp-block-paragraph\">For the new study, published in the <a href=\"https:\/\/www.cell.com\/stem-cell-reports\/home\" rel=\"nofollow noopener\" target=\"_blank\">journal Stem Cell Reports<\/a>, the Japanese team created mouse embryos genetically unable to form kidneys, leaving a developmental niche that could be filled by injected embryonic stem cells.<\/p>\n<p class=\"wp-block-paragraph\">Dr. Shunsuke Yuri, of the <a href=\"https:\/\/www.ncgg.go.jp\/english\/\" rel=\"nofollow noopener\" target=\"_blank\">National Center for Geriatrics and Gerontology<\/a> in Obu City, said: &#8220;When rat embryonic stem cells were introduced into these embryos, they contributed extensively to kidney formation, particularly to nephron progenitor cells and ureteric bud lineages, resulting in the generation of a rat cell-derived kidney.<\/p>\n<p class=\"wp-block-paragraph\">&#8220;Although the interspecies embryos did not survive to birth, preventing assessment of kidney function, the study demonstrates the potential of using one species to generate organs from another.&#8221;<\/p>\n<p class=\"wp-block-paragraph\">Dr. Ayako Isotani, of the <a href=\"https:\/\/bsw3.naist.jp\/isotani\/index-en.html\" rel=\"nofollow noopener\" target=\"_blank\">Nara Institute of Science and Technology<\/a>, added: &#8221; The findings represent an important step toward future efforts to grow transplantable human organs in larger animals, such as pigs, with the long-term goal of helping address the global shortage of donor kidneys.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"(S.Yuri\/A.Isotani\/N.I.S.T via SWNS) By Talker By Stephen Beech Rat kidneys have been successfully grown in mice \u2014 offering&hellip;\n","protected":false},"author":2,"featured_media":530295,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_share_on_mastodon":"0"},"categories":[78],"tags":[18,135,19,17,19412],"class_list":["post-530294","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-eire","tag-health","tag-ie","tag-ireland","tag-stephen-beech"],"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@ie\/116732917870430257","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts\/530294","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/comments?post=530294"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts\/530294\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/media\/530295"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/media?parent=530294"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/categories?post=530294"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/tags?post=530294"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}