uveitis<\/a> compared to healthy individuals, and the risk is increased with coexisting diabetic retinopathy (DR) and advancing stages of DR, according to a real-world data analysis from the Case Western Reserve University School of Medicine.1<\/p>\nDR is among the most prevalent complications of diabetes, affecting almost 1 in 3 patients with diabetes globally. It is also a leading cause of blindness, given the irreversible damage it inflicts on the retina. Despite effective therapies such as anti-VEGF injections and photocoagulation, limitations such as drug resistance, partial therapeutic responses, and low patient compliance resulting from a reliance on intravitreal injections are consistently unresolved.2<\/p>\n
In addition to DR, diabetes mellitus can also negatively impact the course and outcome of uveitis. Preexisting diabetes has long been associated with a greater inflammatory response during uveitis episodes, which translates to a higher degree of complications. Poor glycemic control, frequently caused by side effects of medication used to treat uveitis, can also be linked to more severe inflammation.3<\/p>\n
The retrospective cohort study utilized data from the TriNetX Global Collaborative Network. Included patients had to have a diagnosis of type 1 diabetes (T1D) or type 2 diabetes (T2D); investigators included both insulin users and non-insulin users among those with T2D, with and without DR. The team also employed 1:1 propensity score matching, adjusting for demographic variables and relevant medical conditions, to ensure compatibility between cohorts.1<\/p>\n
Ultimately, investigators saw a substantially greater risk of uveitis in patients with T2DM, irrespective of DR, compared to the control group (adjusted hazard ratio [HR], 6.054; 95% CI, 5.484-6.683 and 1.381; 95% CI, 1.254-1.521). The risk remained high at 5- and 10-year follow-ups. In patients with T1D and DR, the HR increased compared to control from years 1 to 10 (HR at 1 year, 2.274; 95% CI, 1.137-4.547). Additionally, patients with T2D and non-proliferative DR saw a reduced uveitis risk versus those with T2D and proliferative DR at years 1-10 (HR at 1 year, 0.339; 95% CI, 0.302-0.380).1<\/p>\n
Ultimately, investigators concluded that patients with T2D have a higher risk of uveitis, which increases with coexisting DR. Patients with T1D are also at an increased risk, albeit a lesser one.1<\/p>\n
\u201cThese findings emphasize the critical need for vigilant monitoring and targeted interventions to manage ocular health complications in diabetic populations,\u201d wrote Darren Jindal, PhD, a researcher at Columbia University Irving Medical Center, and colleagues.1<\/p>\n
References<\/p>\n
\n- Jindal, D. A., Alshammari, N., Dihan, Q., Chauhan, M. Z., Gupta, V., Soliman, M. K., & Sallam, A. B. (2025). The Association of Diabetes Mellitus with Uveitis: A Real-World Data Analysis. Ocular Immunology and Inflammation, 1\u20139. https:\/\/doi.org\/10.1080\/09273948.2025.2548333<\/a><\/li>\n
- Seo H, Park SJ, Song M. Diabetic Retinopathy (DR): Mechanisms, Current Therapies, and Emerging Strategies. Cells. 2025;14(5):376. Published 2025 Mar 4. doi:10.3390\/cells14050376<\/a><\/li>\n
- Mohapatra A, Sudharshan S, Majumder PD, Sreenivasan J, Raman R. Clinical Profile and Ocular Morbidities in Patients with Both Diabetic Retinopathy and Uveitis. Ophthalmol Sci. 2024;4(6):100511. Published 2024 Mar 7. doi:10.1016\/j.xops.2024.100511<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"Darren Jindal, PhD | Image Credit: Case Western Reserve University School of Medicine Patients with type 1 or…\n","protected":false},"author":2,"featured_media":56292,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[78],"tags":[2904,2908,2901,2906,2675,686,718,18,2909,2898,1910,135,474,2911,19,2913,2902,1911,2810,17,693,96,5,2907,2900,2899,1944,2903,171,2905,2912,172,2910,133,2897],"class_list":{"0":"post-56291","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-allergy","9":"tag-cardiology","10":"tag-clinicians","11":"tag-dermatology","12":"tag-diabetes","13":"tag-doctors","14":"tag-drugs","15":"tag-eire","16":"tag-endocrinology","17":"tag-fda","18":"tag-gastroenterology","19":"tag-health","20":"tag-healthcare","21":"tag-hematology","22":"tag-ie","23":"tag-infectious-disease","24":"tag-insight","25":"tag-internal-medicine","26":"tag-interviews","27":"tag-ireland","28":"tag-medical","29":"tag-medicine","30":"tag-news","31":"tag-ophthalmology","32":"tag-pharmaceuticals","33":"tag-pipeline","34":"tag-primary-care","35":"tag-providers","36":"tag-psychiatry","37":"tag-pulmonology","38":"tag-rare-disease","39":"tag-research","40":"tag-rheumatology","41":"tag-science","42":"tag-treatments"},"share_on_mastodon":{"url":"","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts\/56291","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/comments?post=56291"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts\/56291\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/media\/56292"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/media?parent=56291"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/categories?post=56291"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/tags?post=56291"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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