{"id":632490,"date":"2026-08-12T03:16:10","date_gmt":"2026-08-12T03:16:10","guid":{"rendered":"https:\/\/www.europesays.com\/ie\/632490\/"},"modified":"2026-08-12T03:16:10","modified_gmt":"2026-08-12T03:16:10","slug":"immune-memory-mechanism-emerges-as-a-promising-target-in-diabetes-and-its-complications","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/ie\/632490\/","title":{"rendered":"Immune Memory Mechanism Emerges as a Promising Target in Diabetes and Its Complications"},"content":{"rendered":"

Newswise \u2014 A growing understanding of\u00a0trained immunity<\/strong>, a form of long-lasting immune system adaptation, is reshaping how scientists view\u00a0diabetes<\/strong>\u00a0and its many complications. A new review highlights how persistent changes in the body\u2019s innate immune system may contribute to the development of diabetes, worsen disease progression, and create new opportunities for treatment.<\/p>\n

Diabetes affects hundreds of millions of people worldwide and is a leading cause of\u00a0cardiovascular disease<\/strong>,\u00a0kidney disease<\/strong>, vision loss, and other serious health problems. While high blood sugar has long been recognized as a central driver of these complications, increasing attention is now focused on the role of chronic inflammation and immune dysfunction.<\/p>\n

The review explains that trained immunity occurs when innate immune cells, such as\u00a0monocytes<\/strong>\u00a0and\u00a0macrophages<\/strong>, undergo lasting changes after exposure to metabolic stress or inflammatory signals. These cells become primed to respond more aggressively to future challenges, creating a sustained inflammatory state that can persist even after the original trigger has disappeared. This phenomenon links metabolic disturbances directly to immune system behavior.<\/p>\n

According to the review, factors commonly associated with diabetes\u2014including\u00a0hyperglycemia<\/strong>,\u00a0obesity<\/strong>,\u00a0lipid abnormalities<\/strong>, and changes in the\u00a0gut microbiome<\/strong>\u2014can activate trained immunity pathways. The resulting inflammatory responses may promote\u00a0insulin resistance<\/strong>, impair the function of insulin-producing\u00a0beta cells<\/strong>, and accelerate damage throughout the body.<\/p>\n

The effects extend beyond diabetes itself. Evidence summarized in the review suggests that trained immunity may contribute to the progression of\u00a0atherosclerosis<\/strong>,\u00a0diabetic kidney disease<\/strong>, delayed\u00a0wound healing<\/strong>, and potentially other diabetes-related complications. Persistent immune activation appears to influence tissue injury, fibrosis, vascular dysfunction, and chronic inflammation across multiple organs.<\/p>\n

The review also identifies several promising therapeutic directions. Potential approaches include targeting inflammatory pathways such as the\u00a0NLRP3 inflammasome<\/strong>, modifying cellular metabolism, improving gut microbial balance through\u00a0dietary interventions<\/strong>\u00a0and microbiome-focused therapies, and exploring\u00a0vaccination strategies<\/strong>\u00a0that influence immune programming. These approaches aim not only to control blood glucose levels but also to address the underlying immune mechanisms that drive disease progression.<\/p>\n

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Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative reviews that focus on the molecular bases of human diseases. Emphasis is placed on hypothesis-driven, mechanistic studies relevant to pathogenesis and\/or experimental therapeutics of human diseases. The journal has worldwide authorship, and a broad scope in basic and translational biomedical research of molecular biology, molecular genetics, and cell biology, including but not limited to cell proliferation and apoptosis, signal transduction, stem cell biology, developmental biology, gene regulation and epigenetics, cancer biology, immunity and infection, neuroscience, disease-specific animal models, gene and cell-based therapies, and regenerative medicine.
Scopus CiteScore:<\/strong>\u00a010.4 |Impact Factor:<\/strong>14.6<\/p>\n

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More information:\u00a0<\/strong>https:\/\/www.keaipublishing.com\/en\/journals\/genes-and-diseases\/<\/a>
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All issues and articles in press are available\u00a0online<\/a>\u00a0in\u00a0ScienceDirect<\/a>\u00a0(https:\/\/www.sciencedirect.com\/journal\/genes-and-diseases<\/a>).
Submissions to\u00a0Genes & Diseases\u00a0<\/strong>may be made using\u00a0Editorial Manager<\/a>\u00a0(https:\/\/www.editorialmanager.com\/gendis\/default.aspx<\/a>).
Print ISSN:<\/strong>\u00a02352-4820
eISSN:<\/strong>\u00a02352-3042
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Reference<\/strong>
Qiming Gong, Yuqing Huang, Fahui Liu, Tingting Zhou, Wei Huang, Yong Xu, Trained immunity: New insights into pathogenesis and therapeutic targets in diabetes and diabetic complications, Genes & Diseases, Volume 13, Issue 5, 2026, 101940,\u00a0https:\/\/doi.org\/10.1016\/j.gendis.2025.101940<\/a><\/p>\n

Funding<\/strong>
Natural Science Foundation of China\u00a082170834<\/a>
Natural Science Foundation of China\u00a0U22A20286<\/a>
Natural Science Foundation of China\u00a082470854<\/a>
Sichuan Science and Technology Program (China)\u00a02024YFFK0081<\/a>
Sichuan Province Cadre Health Research Project (China)\u00a0ZH2022-1501<\/a>
Health Commission of Sichuan Province Medical Science and Technology Program (China)\u00a024CXTD02<\/a>
Clinical Medicine Special Project of Southwest Medical University (Sichuan, China)\u00a02024LCYXZX02<\/a>
Clinical Medicine Special Project of Southwest Medical University (Sichuan, China)\u00a02024LCYXZX12<\/a>
Graduate Education and Teaching Program of Southwest Medical University (Sichuan, China)\u00a0YJG202291<\/a>
Graduate Education and Teaching Program of Southwest Medical University (Sichuan, China)\u00a0ZYTS-29<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"Newswise \u2014 A growing understanding of\u00a0trained immunity, a form of long-lasting immune system adaptation, is reshaping how scientists…\n","protected":false},"author":2,"featured_media":632491,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_share_on_mastodon":"0"},"categories":[78],"tags":[7260,2432,2675,267271,18,135,474,19,5533,17,1698,6106,941,267225,7176,30607],"class_list":["post-632490","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-all-journal-news","tag-cardiovascular-health","tag-diabetes","tag-diabeteschronic-inflammationimmune-dysfunctioninsulin-resistancetherapeutic-targetsgut-microbiomeatherosclerosis","tag-eire","tag-health","tag-healthcare","tag-ie","tag-immunology","tag-ireland","tag-kidney-disease","tag-microbiome","tag-newswise","tag-newswise-review","tag-obesity","tag-regenerative-medicine"],"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@ie\/117080371368979144","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts\/632490","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/comments?post=632490"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/posts\/632490\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/media\/632491"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/media?parent=632490"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/categories?post=632490"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/ie\/wp-json\/wp\/v2\/tags?post=632490"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}