Israel launched strikes on targets in Iran late Sunday after Iranian missiles were fired toward northern Israel, escalating tensions despite reported efforts by U.S. President Donald Trump to prevent further military retaliation.

According to Iranian state media, powerful explosions were heard in Tehran and the central city of Isfahan, while semi-official outlets reported additional blasts in Tabriz and other locations in western Iran. Iranian authorities have not yet released details on casualties or damage.

The latest exchange came after Iran launched a new wave of missiles toward Israel, accusing it of repeatedly violating a ceasefire through ongoing military operations in Lebanon. Israeli officials have not immediately disclosed the specific targets of their strikes inside Iran.

The escalation follows an Israeli strike on Beirut’s southern suburbs that reportedly killed at least two people and wounded 20 others, further heightening fears of a broader regional conflict involving Iran-backed groups across the Middle East.

The United States has been seeking to contain the crisis amid growing concerns over regional stability and global energy supplies. Trump reportedly urged Israeli Prime Minister Benjamin Netanyahu to exercise restraint and avoid actions that could further escalate the confrontation.

The renewed hostilities come as indirect diplomatic efforts to ease tensions between Washington and Tehran remain stalled. Recent fighting in and around the Strait of Hormuz, including missile, drone and maritime incidents, has raised concerns about the security of one of the world’s most important oil transit routes.

The conflict has also deepened the humanitarian crisis across the region. Continued fighting in Gaza, cross-border exchanges between Israel and Hezbollah in Lebanon, and the widening confrontation with Iran have displaced civilians, strained humanitarian operations and increased international calls for an immediate de-escalation.