Wednesday, March 18, 2026<\/p>\n
New program\u00a0will develop,\u00a0validate\u00a0and standardize research tools to\u00a0develop more sophisticated and relevant models of disease.\u00a0<\/p>\n
<\/p>\n Wyss Institute, Harvard University<\/p>\n <\/a> <\/p>\n The\u00a0National Institutes of Health (NIH)\u00a0today\u00a0announced\u00a0more than\u00a0$150 million\u00a0to\u00a0develop and scale research methods that better simulate human biology and reduce reliance on animal models, a\u00a0priority of the Trump Administration.\u00a0The funding marks the first awards under the\u00a0Complement Animal Research in Experimentation (Complement-ARIE) program,\u00a0an initiative\u00a0to\u00a0develop,\u00a0implement, and standardize\u00a0lab or computer-based\u00a0methods, also known as\u00a0new\u00a0approach\u00a0methodologies\u00a0(NAMs).\u00a0Research teams across the United States will lead projects designed to produce more predictive models of human disease.\u00a0<\/p>\n \u201cThis is an exciting opportunity to\u00a0create\u00a0a repertoire of\u00a0human-focused\u00a0methods\u00a0that are so sophisticated and comprehensive\u00a0that\u00a0successful clinical translation will rise and\u00a0we will be able to answer questions\u00a0beyond our reach\u00a0with\u00a0current\u00a0research\u00a0models,\u201d\u00a0said Nicole Kleinstreuer, Ph.D., NIH Deputy Director for Program Coordination, Planning, and Strategic Initiatives.\u00a0\u201cThese new projects\u00a0are\u00a0key steps\u00a0in\u00a0expanding\u00a0and strengthening\u00a0our scientific\u00a0toolbox. NIH\u2019s\u00a0investment\u00a0in NAMs\u00a0is critical\u00a0to our mission to carry out gold-standard research.\u201d<\/p>\n The program will\u00a0establish technology\u00a0development\u00a0centers (TDCs) to\u00a0facilitate\u00a0NAM\u00a0development\u00a0in\u00a0the\u00a0areas of greatest\u00a0scientific\u00a0and\u00a0regulatory need.\u00a0Examples include NAMs technologies to study gynecological disorders, cardiac disease, neurological\u00a0disorders, rare diseases,\u00a0and more<\/a>.\u00a0A\u00a0NAMs\u00a0data\u00a0hub and\u00a0coordinating\u00a0center (NDHCC)\u00a0will\u00a0facilitate\u00a0data sharing and standards\u00a0development, while\u00a0a\u00a0validation and\u00a0qualification\u00a0network (VQN)\u00a0will\u00a0leverage\u00a0a\u00a0public-private partnership with industry and regulatory\u00a0expertise\u00a0necessary\u00a0to implement\u00a0reliable,\u00a0marketable\u00a0NAMs.\u00a0<\/p>\n Complement-ARIE\u00a0has partnered with the Foundation for the National Institutes of Health\u00a0to\u00a0establish\u00a0the\u00a0VQN<\/a>, intended to\u00a0advance implementation of\u00a0reliable and\u00a0marketable NAMs,\u00a0preparing them for\u00a0regulatory processes and clearance.\u00a0NIH plans to contribute about $20 million, pending available funds. The network has selected four pilot projects focused on\u00a0preterm birth, developmental neurotoxicity, inhalation\u00a0toxicity\u00a0and acute oral toxicity, with plans to expand.<\/p>\n Additionally, the program\u00a0launched\u00a0a $7 million\u00a0NAMs\u00a0Reduction to Practice Challenge<\/a>\u00a0in partnership with\u00a0the\u00a0U.S.\u00a0Food and Drug Administration and the\u00a0Environmental Protection Agency\u00a0where\u00a0research teams\u00a0submitted\u00a0human-based NAMs\u00a0to\u00a0demonstrate\u00a0viability\u00a0within a\u00a0three-year period\u00a0and\u00a0be delivered\u00a0to the VQN.\u00a0\u00a0<\/p>\n Funding for these projects\u00a0will be provided by\u00a0awards\u00a0UM1TR006029; UM1TR006046;\u00a0UM1TR006054;\u00a0UM1TR006055;\u00a0UM1TR006070;\u00a0U24ES038377;\u00a0OT2OD039875.\u00a0<\/p>\n About the National Institutes of Health (NIH): NIH, the nation’s medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov<\/a>.<\/p>\n NIH\u2026Turning Discovery Into Health\u00ae<\/p>\n","protected":false},"excerpt":{"rendered":"Wednesday, March 18, 2026 New program\u00a0will develop,\u00a0validate\u00a0and standardize research tools to\u00a0develop more sophisticated and relevant models of disease.\u00a0…\n","protected":false},"author":2,"featured_media":6919,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[5557,8,5555,5554,9,5553,5556,3333,7],"class_list":{"0":"post-6918","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-top-stories","8":"tag-animal-models","9":"tag-headlines","10":"tag-human-based","11":"tag-invests","12":"tag-news","13":"tag-nih","14":"tag-reduce","15":"tag-research","16":"tag-top-stories"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@news\/116253225266195227","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/news\/wp-json\/wp\/v2\/posts\/6918","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/news\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/news\/wp-json\/wp\/v2\/comments?post=6918"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/news\/wp-json\/wp\/v2\/posts\/6918\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/news\/wp-json\/wp\/v2\/media\/6919"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/news\/wp-json\/wp\/v2\/media?parent=6918"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/news\/wp-json\/wp\/v2\/categories?post=6918"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/news\/wp-json\/wp\/v2\/tags?post=6918"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}