biomarkerii \u00eemb\u0103tr\u00e2nirii<\/a> pentru a vedea dac\u0103 pot identifica schimb\u0103rile asociate.<\/p>\nFolosind probele colectate, cercet\u0103torii au urm\u0103rit diferite tipuri de biomolecule. Moleculele studiate au inclus RNA, proteine, lipide \u0219i taxoni din microbiomul intestinului, pielii, nasului \u0219i cavit\u0103\u021bii bucale, pentru un total de 135.239 de caracteristici biologice.<\/p>\n
Fiecare participant a trimis, \u00een medie, 47 de probe pe parcursul a 626 de zile, cel mai fidel participant oferind 367 de probe. Aceast\u0103 cantitate impresionant\u0103 de date a generat peste 246 de miliarde de puncte de date, pe care cercet\u0103torii le-au procesat, c\u0103ut\u00e2nd tipare \u00een schimb\u0103ri.<\/p>\n
Snyder \u0219i colegii s\u0103i au observat o schimbare distinct\u0103 \u00een abunden\u021ba multor tipuri de molecule \u00een corpul uman, \u00een dou\u0103 etape clar delimitate.<\/p>\n
Aproximativ 81% din toate moleculele studiate au prezentat modific\u0103ri \u00een una sau ambele etape. Schimb\u0103rile au atins un v\u00e2rf la mijlocul vie\u021bii, \u00een jurul v\u00e2rstei de 40 \u0219i ceva de ani, \u0219i din nou la \u00eenceputul v\u00e2rstei de 60 de ani, cu profile u\u0219or diferite.<\/p>\n
V\u00e2rful de la mijlocul vie\u021bii a ar\u0103tat modific\u0103ri \u00een moleculele asociate cu metabolismul lipidelor, al cafelei \u0219i al alcoolului, precum \u0219i cu bolile cardiovasculare \u0219i disfunc\u021biile pielii \u0219i musculare.<\/p>\n
V\u00e2rful de la \u00eenceputul v\u00e2rstei de 60 de ani a fost asociat cu metabolismul carbohidra\u021bilor \u0219i al cafelei, bolile cardiovasculare, pielea \u0219i mu\u0219chii, reglarea imunit\u0103\u021bii \u0219i func\u021bia rinichilor.<\/p>\n
Primul v\u00e2rf, cel din mijlocul vie\u021bii, este de obicei perioada c\u00e2nd femeile intr\u0103 la menopauz\u0103 sau perimenopauz\u0103, \u00eens\u0103 cercet\u0103torii au exclus acest factor ca principal: \u0219i b\u0103rba\u021bii au prezentat schimb\u0103ri moleculare semnificative la aceea\u0219i v\u00e2rst\u0103.<\/p>\n
\u201eAcest lucru sugereaz\u0103 c\u0103, de\u0219i menopauza sau perimenopauza pot contribui la schimb\u0103rile observate la femeile de 40 \u0219i ceva de ani, probabil exist\u0103 \u0219i al\u021bi factori, mai importan\u021bi, care influen\u021beaz\u0103 aceste modific\u0103ri la ambele sexe,\u201d a explicat metabolomistul \u0219i primul autor Xiaotao Shen, fost cercet\u0103tor la Stanford, acum la Nanyang Technological University din Singapore. \u201eIdentificarea \u0219i studierea acestor factori ar trebui s\u0103 fie o prioritate pentru cercet\u0103rile viitoare.\u201d<\/p>\n
Cercet\u0103torii men\u021bioneaz\u0103 c\u0103 dimensiunea e\u0219antionului este destul de mic\u0103 \u0219i c\u0103 au testat probe biologice limitate, de la persoane cu v\u00e2rste \u00eentre 25 \u0219i 70 de ani. Studiul a fost publicat \u00een revista Nature Aging.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"Potrivit unui studiu din 2024 privind schimb\u0103rile moleculare asociate cu \u00eemb\u0103tr\u00e2nirea, oamenii trec prin dou\u0103 salturi bru\u0219te, unul…\n","protected":false},"author":2,"featured_media":116925,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12],"tags":[32,33,31,36,37,27,8832,74,34,35,25,41,40,38,39,26,2475,28,29,30,71,72,73],"class_list":{"0":"post-116924","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-international","8":"tag-breaking-news","9":"tag-breakingnews","10":"tag-cele-mai-populare-subiecte","11":"tag-featured-news","12":"tag-featurednews","13":"tag-headlines","14":"tag-imbatranire","15":"tag-international","16":"tag-latest-news","17":"tag-latestnews","18":"tag-news","19":"tag-ro","20":"tag-romana","21":"tag-romania","22":"tag-romanian","23":"tag-stiri","24":"tag-studiu","25":"tag-titluri","26":"tag-top-stories","27":"tag-topstories","28":"tag-world","29":"tag-world-news","30":"tag-worldnews"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@ro\/116092270176719832","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/posts\/116924","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/comments?post=116924"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/posts\/116924\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/media\/116925"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/media?parent=116924"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/categories?post=116924"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/tags?post=116924"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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