{"id":35916,"date":"2025-11-04T19:51:04","date_gmt":"2025-11-04T19:51:04","guid":{"rendered":"https:\/\/www.europesays.com\/ro\/35916\/"},"modified":"2025-11-04T19:51:04","modified_gmt":"2025-11-04T19:51:04","slug":"cercetatorii-au-reusit-sa-reactiveze-mecanismul-natural-de-reparare-a-inimii","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/ro\/35916\/","title":{"rendered":"Cercet\u0103torii au reu\u015fit s\u0103 reactiveze mecanismul natural de reparare a inimii"},"content":{"rendered":"

\n\t\t\t\t\t\tDimensiune text<\/p>\n

\t\t\t\t\t\t\tMic\u0103
\n\t\t\t\t\t\t\tNormal\u0103
\n\t\t\t\t\t\t\tMare<\/p>\n

Cercet\u0103torii americani de la Mount Sinai Health System au descoperit c\u0103 o gen\u0103 uman\u0103, care devine inactiv\u0103 dup\u0103 na\u015ftere, poate fi reactivat\u0103 pentru a stimula formarea de noi celule cardiace \u015fi pentru a ajuta inima s\u0103 se refac\u0103 dup\u0103 un infarct miocardic sau insuficien\u0163\u0103 cardiac\u0103, transmite News.ro.<\/p>\n

Genele implicate \u00een diviziunea celular\u0103 sunt active doar \u00een perioada fetal\u0103, c\u00e2nd inima se dezvolt\u0103. Dup\u0103 na\u015ftere, aceste gene se \u201eopresc\u201d<\/a>, iar celulele musculare ale inimii ( numite cardiomiocite) nu se mai divid, ceea ce explic\u0103 de ce \u0163esutul cardiac nu se poate repara singur dup\u0103 un infarct.<\/p>\n

Un studiu publicat, luni, \u00een revista \u015ftiin\u0163ific\u0103\u00a0npj Regenerative Medicine<\/a>, deschide o nou\u0103 cale c\u0103tre terapii regenerative care ar putea, \u00eentr-o zi, s\u0103 \u00eenlocuiasc\u0103 transplanturile de inim\u0103 sau dispozitivele mecanice de sus\u0163inere cardiac\u0103.<\/p>\n

O echip\u0103 de cercet\u0103tori, condus\u0103 de dr. Hina Chaudhry, director al Programului de Medicin\u0103 Regenerativ\u0103 Cardiovascular\u0103 la Icahn School of Medicine at Mount Sinai, a reu\u015fit s\u0103 \u201etrezeasc\u0103\u201d genele latente din inimile umane adulte, ob\u0163in\u00e2nd o regenerare celular\u0103 func\u0163ional\u0103.<\/p>\n

Cercetarea actual\u0103 se bazeaz\u0103 pe\u00a0un studiu din 2014<\/a>\u00a0al aceleia\u015fi echipe, publicat \u00een revista\u00a0Science Translational Medicine<\/a>, \u00een care a fost demonstrat\u0103 regenerarea inimii unui porc prin reactivarea genei\u00a0numite Cyclin A2 (CCNA2)\u00a0\u2013 o premier\u0103 mondial\u0103 la acea vreme.<\/p>\n

Noile rezultate confirm\u0103 c\u0103 acela\u015fi mecanism poate func\u0163iona \u015fi \u00een celulele cardiace umane adulte, demonstr\u00e2nd siguran\u0163a \u015fi eficien\u0163a utiliz\u0103rii unui vector viral compatibil cu organismul uman pentru a declan\u015fa diviziunea celular\u0103.<\/p>\n

Pentru experiment, cercet\u0103torii au introdus gena CCNA2 \u00eentr-un virus inofensiv, care a fost aplicat pe celule musculare cardiace umane prelevate de la donatori s\u0103n\u0103to\u015fi cu v\u00e2rste de 21, 41 \u015fi 55 de ani.<\/p>\n

\u00cen cazul inimilor provenite de la donatori de 41 \u015fi 55 de ani, celulele au \u00eenceput s\u0103 se divid\u0103 din nou, p\u0103str\u00e2ndu-\u015fi \u00een acela\u015fi timp structura \u015fi func\u0163ia normal\u0103.<\/p>\n

\u00cen schimb, celulele unui donator de 21 de ani nu au prezentat modific\u0103ri, ceea ce confirm\u0103 faptul c\u0103 inimile tinere au o capacitate natural\u0103 de regenerare <\/a>mai ridicat\u0103.
Analizele ulterioare au ar\u0103tat c\u0103 noile celule rezultate \u00een urma diviziunii \u015fi-au p\u0103strat proteinele structurale \u015fi activitatea normal\u0103 a calciului, indic\u00e2nd faptul c\u0103 sunt complet func\u0163ionale.<\/p>\n

Gena CCNA2 pare s\u0103 reactiveze temporar unele programe genetice de cre\u015ftere, permi\u0163\u00e2nd celulelor s\u0103 \u201edea timpul \u00eenapoi\u201d<\/a> pentru a se repara, f\u0103r\u0103 a deveni imature sau a produce \u00eengro\u015farea patologic\u0103 a \u0163esutului cardiac observat\u0103 \u00een unele boli.<\/p>\n

Dr. Chaudhry a declarat c\u0103 rezultatele vin dup\u0103 \u201eaproape dou\u0103 decenii de cercetare\u201d, subliniind c\u0103 scopul final este dezvoltarea unei terapii care s\u0103 permit\u0103 inimii umane s\u0103 se vindece singur\u0103 dup\u0103 un infarct sau \u00een insuficien\u0163\u0103 cardiac\u0103, reduc\u00e2nd astfel nevoia de transplant sau de dispozitive mecanice.<\/p>\n

Echipa \u00ee\u015fi propune acum s\u0103 solicite aprobarea autorit\u0103\u0163ilor americane de reglementare \u00een domeniul s\u0103n\u0103t\u0103\u0163ii, FDA, pentru \u00eenceperea studiilor clinice pe pacien\u0163i cu boli de inim\u0103. Dac\u0103 rezultatele vor fi confirmate, terapia cu CCNA2 ar putea marca \u00eenceputul unei noi etape \u00een medicina regenerativ\u0103 cardiac\u0103.<\/p>\n","protected":false},"excerpt":{"rendered":"Dimensiune text Mic\u0103 Normal\u0103 Mare Cercet\u0103torii americani de la Mount Sinai Health System au descoperit c\u0103 o gen\u0103…\n","protected":false},"author":2,"featured_media":35917,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12],"tags":[32,33,31,416,36,37,27,492,74,34,35,15222,25,41,40,38,39,26,28,29,30,71,72,73],"class_list":{"0":"post-35916","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-international","8":"tag-breaking-news","9":"tag-breakingnews","10":"tag-cele-mai-populare-subiecte","11":"tag-cercetatori","12":"tag-featured-news","13":"tag-featurednews","14":"tag-headlines","15":"tag-inima","16":"tag-international","17":"tag-latest-news","18":"tag-latestnews","19":"tag-mecanism-reparare","20":"tag-news","21":"tag-ro","22":"tag-romana","23":"tag-romania","24":"tag-romanian","25":"tag-stiri","26":"tag-titluri","27":"tag-top-stories","28":"tag-topstories","29":"tag-world","30":"tag-world-news","31":"tag-worldnews"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@ro\/115493174183799275","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/posts\/35916","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/comments?post=35916"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/posts\/35916\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/media\/35917"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/media?parent=35916"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/categories?post=35916"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/tags?post=35916"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}