{"id":4055,"date":"2025-09-26T06:32:09","date_gmt":"2025-09-26T06:32:09","guid":{"rendered":"https:\/\/www.europesays.com\/ro\/4055\/"},"modified":"2025-09-26T06:32:09","modified_gmt":"2025-09-26T06:32:09","slug":"genetica-dezvaluie-ultimul-secret-al-mariei-branyas-femeia-care-a-trait-117-ani-cum-a-sfidat-timpul-si-imbatranirea","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/ro\/4055\/","title":{"rendered":"Genetica dezv\u0103luie ultimul secret al Mariei Branyas, femeia care a tr\u0103it 117 ani: cum a sfidat timpul \u0219i \u00eemb\u0103tr\u00e2nirea"},"content":{"rendered":"

Maria Branyas, femeia din Catalonia \u2013 Spania care a tr\u0103it peste\u00a0117 ani<\/a>, continu\u0103 s\u0103 uimeasc\u0103 lumea medical\u0103.<\/p>\n

\t\t\t\"<\/p>\n

Maria Branyas femeia care a tr\u0103it 117 ani \u00eenc\u0103 uime\u0219te lumea medical\u0103 Foto Super Avia Catalana<\/p>\n

Un\u00a0studiu amplu<\/a>, publicat recent \u00een revista Cell Reports Medicine, a analizat \u00een detaliu \u201ecodul biologic\u201d al celei mai longevive persoane \u00eenregistrate vreodat\u0103 \u0219i a scos la iveal\u0103 un paradox fascinant: organismul s\u0103u prezenta simultan semne de \u00eemb\u0103tr\u00e2nire extrem\u0103 \u0219i tr\u0103s\u0103turi asociate cu longevitatea s\u0103n\u0103toas\u0103, practic poseda un genom excep\u021bional de t\u00e2n\u0103r, \u00een ciuda v\u00e2rstei. Unele dintre genele sale rare au contribuit la longevitate \u0219i au sprijinit s\u0103n\u0103tatea sistemului imunitar, a inimii \u0219i a creierului.\u00a0<\/p>\n

Cercet\u0103torii au descoperit c\u0103, pe l\u00e2ng\u0103\u00a0factorii genetici\u00a0favorabili, Maria beneficia de un stil de via\u021b\u0103 excep\u021bional \u2013 diet\u0103 echilibrat\u0103, activitate fizic\u0103 regulat\u0103 \u0219i conexiuni sociale str\u00e2nse \u2013 care, combinate, ar putea explica remarcabila sa capacitate de a men\u021bine s\u0103n\u0103tatea la v\u00e2rste extreme.\u00a0<\/p>\n

Studiul ADN nu doar c\u0103 aduce lumina asupra mecanismelor biologice ale\u00a0longevit\u0103\u021bii<\/a>, dar deschide \u0219i noi direc\u021bii pentru cercetarea bolilor legate de \u00eemb\u0103tr\u00e2nirea organismului.<\/p>\n

\u00cen continuare, cititorii vor descoperi ce anume a f\u0103cut ca organismul Mariei Branyas s\u0103 fie at\u00e2t de rezistent la \u00eemb\u0103tr\u00e2nire, cum combina\u021bia \u00eentre genetic\u0103 \u0219i stil de via\u021b\u0103 a contribuit la longevitatea sa remarcabil\u0103 \u0219i ce lec\u021bii pot extrage cercet\u0103torii pentru s\u0103n\u0103tatea noastr\u0103.<\/p>\n

\t\t\t\"Tr\u0103s\u0103turi<\/p>\n

Tr\u0103s\u0103turi tinere\u0219ti \u0219i semne de \u00eemb\u0103tr\u00e2nire la Maria Branyas Surs\u0103 Santos Pujol Cell Report Medicine<\/p>\n

\t\t\tLongevitatea Mariei Branyas: \u00eentre limite biologice \u0219i miracolul \u0219tiin\u021bei<\/p>\n

\u00cen ultimii 200 de ani, speran\u021ba de via\u021b\u0103 a crescut constant, dar \u00een prezent pare s\u0103 fi ajuns la un prag. Chiar \u0219i \u00een \u021b\u0103rile dezvoltate, progresul medical nu mai prelunge\u0219te via\u021ba la fel de spectaculos ca alt\u0103dat\u0103. Tocmai de aceea, cazuri precum cel al Mariei Branyas sunt at\u00e2t de valoroase pentru cercet\u0103tori.<\/p>\n

O echip\u0103 interna\u021bional\u0103 coordonat\u0103 de Manel Esteller, specialist \u00een epigenetic\u0103 la Institutul de Cercetare a Leucemiei Josep Carreras din Barcelona, a realizat cea mai cuprinz\u0103toare analiz\u0103 de p\u00e2n\u0103 acum asupra unui\u00a0supercentenar<\/a>, folosind tehnologii genomice, proteomice, epigenomice \u0219i metabolomice.<\/p>\n

Rezultatele se bazeaz\u0103 pe probe de s\u00e2nge, saliv\u0103, urin\u0103 \u0219i scaun pe care Maria Branyas le-a oferit voluntar \u00eenainte de decesul s\u0103u, \u00een 2024, c\u00e2nd era\u00a0cea mai \u00een v\u00e2rst\u0103 persoan\u0103<\/a>\u00a0din lume.<\/p>\n

\u00cen lucrarea, publicat\u0103 \u00een prestigioasa revist\u0103\u00a0Cell Reports Medicine<\/a>, echipa interna\u021bional\u0103 multidisciplinar\u0103 condus\u0103 de Eloy Santos explic\u0103 faptul c\u0103 cei care ating v\u00e2rste\u00a0supercentenare<\/a>\u00a0nu o fac din cauza unei \u00eent\u00e2rzieri generale a \u00eemb\u0103tr\u00e2nirii. Ei fac acest lucru datorit\u0103 unei \u201edualit\u0103\u021bi fascinante: prezen\u021ba simultan\u0103 a semnelor de b\u0103tr\u00e2ne\u021be extrem\u0103 \u0219i longevitate s\u0103n\u0103toas\u0103\u201d.<\/p>\n

\t\t\tDualitatea fascinant\u0103 a supercentenarilor: b\u0103tr\u00e2ne\u021be \u0219i tinere\u021be \u00een acela\u0219i corp<\/p>\n

Rezultatele arat\u0103 c\u0103 Maria Branyas avea telomeri extrem de scur\u021bi \u2013 un semn clasic al \u00eemb\u0103tr\u00e2nirii \u0219i al duratei limitate de via\u021b\u0103. Telomerii sunt \u201ecapacele de protec\u021bie\u201d de la cap\u0103tul cromozomilor, care se scurteaz\u0103 pe m\u0103sur\u0103 ce celulele \u00eemb\u0103tr\u00e2nesc \u0219i astfel limiteaz\u0103 durata de via\u021b\u0103 a acestora. Sistemul imunitar al Mariei Branyas prezenta semne de \u00eemb\u0103tr\u00e2nire, cum ar fi prezen\u021ba unor limfocite senescente \u0219i episoade locale de inflama\u021bie. <\/p>\n

Cu toate acestea, la nivel general, organismul ei era protejat prin factori genetici lega\u021bi de\u00a0s\u0103n\u0103tatea creierului<\/a>\u00a0\u0219i a inimii, printr-un nivel sc\u0103zut de inflama\u021bie cronic\u0103 de fond \u0219i printr-un\u00a0microbiom intestinal<\/a>\u00a0bogat \u00een bifidobacterii benefice. Mai mult, markerii epigenetici indicau o v\u00e2rst\u0103 biologic\u0103 mai mic\u0103 dec\u00e2t cea cronologic\u0103.<\/p>\n

\t\t\t\"Rezultatul<\/p>\n

Rezultatul studiului legat de cea mai longeviv\u0103 persoan\u0103 din lume, Maria Branyas Foto Manel Esteller<\/p>\n

Mai concret – la o v\u00e2rst\u0103 \u00eenaintat\u0103, Branyas prezenta o s\u0103n\u0103tate general\u0103 remarcabil\u0103, inclusiv o\u00a0s\u0103n\u0103tate cardiovascular\u0103<\/a>\u00a0excelent\u0103 \u0219i niveluri foarte sc\u0103zute de inflama\u021bie. \u00cen ciuda v\u00e2rstei, sistemul ei imunitar \u0219i microbiomul intestinal aveau markeri comparabili cu cei ai unor persoane mult mai tinere. Mai mult, nivelurile de colesterol \u201er\u0103u\u201d \u0219i trigliceride erau extrem de sc\u0103zute, iar colesterolul \u201ebun\u201d era la valori foarte ridicate. To\u021bi ace\u0219ti factori, genetici \u0219i biologici, pot explica s\u0103n\u0103tatea ei excep\u021bional\u0103 \u0219i longevitatea extrem\u0103.<\/p>\n

\t\t\tDieta, mi\u0219carea \u0219i via\u021ba social\u0103: secretele longevit\u0103\u021bii Mariei Branyas<\/p>\n

Noile descoperiri pot oferi indicii pre\u021bioase pentru bolile hematologice grave, precum leucemia, asociate direct cu \u00eemb\u0103tr\u00e2nirea s\u00e2ngelui. Este pentru prima dat\u0103 c\u00e2nd un\u00a0studiu<\/a>\u00a0pe un supercentenar face o distinc\u021bie clar\u0103 \u00eentre efectele \u00eemb\u0103tr\u00e2nirii \u0219i cele ale bolii.<\/p>\n

Chiar dac\u0103 cercet\u0103torii nu pot spune \u00eenc\u0103 \u00een ce m\u0103sur\u0103 obiceiurile de via\u021b\u0103 au contribuit la longevitatea Mariei Branyas, ace\u0219tia subliniaz\u0103 importan\u021ba unor factori precum alimenta\u021bia s\u0103n\u0103toas\u0103, o re\u021bea social\u0103 activ\u0103 \u0219i lipsa viciilor.<\/p>\n

\t\t\t\"Imagini<\/p>\n

Maria Branyas femeia care a tr\u0103it 117 ani Foto Super Avia Catalana<\/p>\n

Maria Branyas a dus o via\u021b\u0103 activ\u0103 din punct de vedere mental, social \u0219i fizic, \u0219i a beneficiat, de asemenea, de noroc genetic. Urma dieta mediteranean\u0103 \u0219i consuma zilnic trei iaurturi, ceea ce ar putea explica echilibrul remarcabil al microbiotei sale intestinale. \u00cen plus, se bucura de o activitate fizic\u0103 regulat\u0103, merg\u00e2nd frecvent pe jos \u0219i evit\u00e2nd alcoolul sau tutunul. Mai mult, \u00ee\u0219i petrecea b\u0103tr\u00e2ne\u021bea aproape de familie, evit\u00e2nd singur\u0103tatea \u2013 un factor cunoscut pentru protec\u021bia \u00eempotriva declinului cognitiv.<\/p>\n

Chiar \u0219i cu telomeri extrem de scur\u021bi, v\u00e2rsta celular\u0103 redus\u0103 a Mariei Branyas nu i-a afectat s\u0103n\u0103tatea \u0219i ar fi putut chiar s\u0103 reduc\u0103 riscul de cancer, demonstr\u00e2nd c\u0103 \u00eenaintarea \u00een v\u00e2rst\u0103 nu \u00eenseamn\u0103 neap\u0103rat degradare biologic\u0103, au concluzionat cercet\u0103torii.<\/p>\n

Aceast\u0103 combina\u021bie de genetic\u0103 favorabil\u0103 \u0219i stil de via\u021b\u0103 echilibrat sugereaz\u0103 c\u0103\u00a0longevitatea<\/a>\u00a0extraordinar\u0103 nu \u021bine doar de \u201enorocul genetic\u201d, ci \u0219i de alegerile cotidiene care sprijin\u0103 s\u0103n\u0103tatea organismului pe termen lung.<\/p>\n

\t\t\tCe urmeaz\u0103 \u00een cercetarea longevit\u0103\u021bii \u0219i studiul supercentenarilor<\/p>\n

\u00cens\u0103\u00a0studii mai ample<\/a>, care au comparat persoanele cu o via\u021b\u0103 excep\u021bional de lung\u0103 cu cele care au tr\u0103it mai pu\u021bin, au identificat biomarkeri specifici care diferen\u021biaz\u0103 indivizii, inclusiv tr\u0103s\u0103turi unice ce le permit un nivel mai ridicat de rezisten\u021b\u0103 la boli. <\/p>\n

Centenarii reprezint\u0103 cel mai rapid grup demografic \u00een cre\u0219tere la nivel global, \u00eens\u0103 doar unul din zece ajunge s\u0103 tr\u0103iasc\u0103 \u00eenc\u0103 un deceniu dup\u0103 \u00eemplinirea v\u00e2rstei de 100 de ani. Cazuri precum cel al Mariei Branyas ofer\u0103 cercet\u0103torilor o oportunitate rar\u0103 de a descoperi mecanismele care fac posibil\u0103 o durat\u0103 de via\u021b\u0103 extrem\u0103.<\/p>\n

Rezultatele noului studiul deschid calea pentru dezvoltarea unor strategii inovatoare anti-\u00eemb\u0103tr\u00e2nire. Terapii epigenetice \u0219i medicamente care combat senescen\u021ba sunt deja folosite \u00een oncologie, iar analiza detaliat\u0103 a supercentenarilor ar putea accelera descoperirea unor tratamente eficiente pentru popula\u021bia general\u0103. Cercetarea a fost finan\u021bat\u0103 printr-un parteneriat public-privat, eviden\u021biind implicarea institu\u021biilor \u0219i funda\u021biilor \u00een sprijinirea cercet\u0103rii\u00a0longevit\u0103\u021bii<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"Maria Branyas, femeia din Catalonia \u2013 Spania care a tr\u0103it peste\u00a0117 ani, continu\u0103 s\u0103 uimeasc\u0103 lumea medical\u0103. Maria…\n","protected":false},"author":2,"featured_media":4056,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[32,33,2986,2987,31,2982,2983,2977,36,37,2975,27,2984,2979,34,35,2971,2972,2981,25,41,40,38,39,215,2974,2976,26,2988,2985,2973,2978,28,29,30,2980],"class_list":{"0":"post-4055","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-titluri","8":"tag-breaking-news","9":"tag-breakingnews","10":"tag-cea-mai-batrana-persoana","11":"tag-cea-mai-longeviva","12":"tag-cele-mai-populare-subiecte","13":"tag-cum-sa-traiesti-mult","14":"tag-dieta-mediteraneana","15":"tag-epigenetica","16":"tag-featured-news","17":"tag-featurednews","18":"tag-genetica","19":"tag-headlines","20":"tag-imbatranire-activa","21":"tag-imbatranire-sanatoasa","22":"tag-latest-news","23":"tag-latestnews","24":"tag-longevitate","25":"tag-maria-branyas","26":"tag-microbiom","27":"tag-news","28":"tag-ro","29":"tag-romana","30":"tag-romania","31":"tag-romanian","32":"tag-sanatate","33":"tag-secretele-longevitatii","34":"tag-stil-de-viata-sanatos","35":"tag-stiri","36":"tag-studiu-adn","37":"tag-studiu-stiintific","38":"tag-supercentenari","39":"tag-telomeri","40":"tag-titluri","41":"tag-top-stories","42":"tag-topstories","43":"tag-viata-lunga"},"share_on_mastodon":{"url":"","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/posts\/4055","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/comments?post=4055"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/posts\/4055\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/media\/4056"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/media?parent=4055"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/categories?post=4055"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/ro\/wp-json\/wp\/v2\/tags?post=4055"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}