{"id":106606,"date":"2025-12-15T11:45:12","date_gmt":"2025-12-15T11:45:12","guid":{"rendered":"https:\/\/www.europesays.com\/se\/106606\/"},"modified":"2025-12-15T11:45:12","modified_gmt":"2025-12-15T11:45:12","slug":"ny-vag-for-att-paverka-cancersignalering","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/se\/106606\/","title":{"rendered":"Ny v\u00e4g f\u00f6r att p\u00e5verka cancersignalering"},"content":{"rendered":"<p>Bild:<\/p>\n<p> <img decoding=\"async\" src=\"https:\/\/www.europesays.com\/se\/wp-content\/uploads\/2025\/12\/GunarSchulte_custom20251205100222.webp.webp\" alt=\"en man i glas\u00f6gon och kostym\"\/><\/p>\n<p>Rubrik:<\/p>\n<p> Gunnar Schulte. Foto: Stefan Bladh<\/p>\n<p>\u2013 Vi visar f\u00f6r f\u00f6rsta g\u00e5ngen att det g\u00e5r att n\u00e5 Frizzled-receptorernas inre ficka med sm\u00e5 molekyler och d\u00e4rmed p\u00e5verka deras funktion, s\u00e4ger <a href=\"https:\/\/ki.se\/en\/people\/gunnar-schulte\" data-entity-type=\"external\" rel=\"nofollow noopener\" target=\"_blank\">Gunnar Schulte<\/a>, professor vid samma institution, KI.\u00a0<\/p>\n<p>Han betonar att detta \u00e4r ett f\u00f6rsta steg:\u00a0<\/p>\n<p>\u2013 Molekylerna \u00e4r \u00e4nnu inte redo som l\u00e4kemedel, men de \u00f6ppnar f\u00f6r nya s\u00e4tt att behandla cancer och andra sjukdomar d\u00e4r den h\u00e4r signalv\u00e4gen \u00e4r st\u00f6rd. Dessutom tillhandah\u00e5ller v\u00e5ra arbeten en tydlig \u201cproof-of-concept\u201d som understryker att man kan minska FZD aktivering p\u00e5 detta s\u00e4ttet. Ett genombrott f\u00f6r f\u00e4ltet.<\/p>\n<p>Forskningen \u00e4r ett samarbete mellan Karolinska Institutet, SciLifeLab, NAISS, KTH och forskare i Tyskland, och har finansierats av bland andra Vetenskapsr\u00e5det, Cancerfonden, SSMF och Novo Nordisk Fonden. Se studierna f\u00f6r information om eventuella intressekonflikter.<\/p>\n<p>Publikationer<\/p>\n<p>&#8221;<a href=\"https:\/\/www.nature.com\/articles\/s41467-025-67147-z\" data-entity-type=\"external\" rel=\"nofollow noopener\" target=\"_blank\">In silico docking yields small molecule negative allosteric modulators targeting the core of Frizzled 7<\/a>&#8221;, Scharf MM, Kinsolving J, Gr\u00e4tz L, Voss JH, Carrasco-Busturia D, Forsberg B, Kolb P, Schulte G. Nature Communications, online 14 december 2025, doi: 10.1038\/41467-025-67147-z.<\/p>\n<p>&#8221;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40992662\/\" data-entity-type=\"external\" rel=\"nofollow noopener\" target=\"_blank\">SAG1.3-derived Frizzled-targeting small-molecule compounds<\/a>&#8221;, Gr\u00e4tz L, Turku A, Kozielewicz P, Bowin CF, Scharf MM, Voss JH, Kinsolving J, Shekhani R, Oliva-Vilarnau N, Koolmeister T, K\u00f6rber M, Lauschke VM, L\u00f6ber S, Gmeiner P, Schulte G. Journal of Biological Chemistry<strong>, <\/strong>online 30 november 2025, doi: 10.1016\/j.jbc.2025.110751.\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"Bild: Rubrik: Gunnar Schulte. Foto: Stefan Bladh \u2013 Vi visar f\u00f6r f\u00f6rsta g\u00e5ngen att det g\u00e5r att n\u00e5&hellip;\n","protected":false},"author":2,"featured_media":106607,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69],"tags":[113,112,34,31,33,32,30],"class_list":{"0":"post-106606","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-halsa","8":"tag-halsa","9":"tag-health","10":"tag-se","11":"tag-svenska","12":"tag-sverige","13":"tag-sweden","14":"tag-swedish"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@se\/115723418084028177","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/posts\/106606","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/comments?post=106606"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/posts\/106606\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/media\/106607"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/media?parent=106606"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/categories?post=106606"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/tags?post=106606"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}