{"id":73234,"date":"2025-11-05T16:33:08","date_gmt":"2025-11-05T16:33:08","guid":{"rendered":"https:\/\/www.europesays.com\/se\/73234\/"},"modified":"2025-11-05T16:33:08","modified_gmt":"2025-11-05T16:33:08","slug":"forskare-kartlagger-hur-hjarnan-utvecklas-och-hur-den-hanterar-inflammation","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/se\/73234\/","title":{"rendered":"Forskare kartl\u00e4gger hur hj\u00e4rnan utvecklas och hur den hanterar inflammation"},"content":{"rendered":"

Bild:<\/p>\n

\"Di<\/p>\n

Rubrik:<\/p>\n

Di Zhang och Rong Fan, forskare vid Yale University.
\nFoto: Yale University<\/p>\n

\u2013 Det var \u00f6verraskande att se att inflammation kan sprida sig till andra delar av hj\u00e4rnan, \u00e4ven utan direkt skada d\u00e4r. Det tyder p\u00e5 att hj\u00e4rnan har ett komplext s\u00e4tt att kommunicera mellan olika omr\u00e5den vid sjukdom, s\u00e4ger Rong Fan, professor vid Yale University, USA, som lett studien tillsammans med Gon\u00e7alo Castelo-Branco.<\/p>\n

Kan ha betydelse f\u00f6r MS<\/strong><\/p>\n

En viktig uppt\u00e4ckt var att genetiska program som aktiveras under hj\u00e4rnans utveckling kan \u00e5teraktiveras vid inflammation i hj\u00e4rnan.<\/p>\n

\u2013 Detta \u00e4r intressant eftersom det kan ge oss ledtr\u00e5dar om hur och varf\u00f6r myelin bryts ned vid sjukdomar som MS. Vi s\u00e5g att inflammation i hj\u00e4rnan kan spridas och p\u00e5verka omr\u00e5den l\u00e5ngt ifr\u00e5n den ursprungliga skadan, vilket kan ge insikter om hur MS utvecklas och ge oss nya verktyg f\u00f6r att behandla sjukdomen, s\u00e4ger Gon\u00e7alo Castelo-Branco.<\/p>\n

Postdoktorerna Di Zhang vid Yale University och Leslie Kirby<\/a> vid Karolinska Institutet \u00e4r delade f\u00f6rstef\u00f6rfattare till artikeln. Forskningen finansierades av bland annat Vetenskapsr\u00e5det, Hj\u00e4rnfonden, Knut och Alice Wallenbergs stiftelse, EU:s Horizon Europe-program och National Institutes of Health i USA. Gon\u00e7alo Castelo-Branco \u00e4r del\u00e4gare i f\u00f6retaget Nexus Epigenomics. Rong Fan \u00e4r grundare och r\u00e5dgivare till IsoPlexis, Singleron Biotechnologies och AtlasXomics.<\/p>\n

Publikation<\/strong><\/p>\n

\u201dSpatial dynamics of brain development and neuroinflammation\u201d<\/a>, Di Zhang, Leslie A Rubio Rodr\u00edguez-Kirby, Yingxin Lin, Wenqi Wang, Mengyi Song, Li Wang, Lijun Wang, Shigeaki Kanatani, Tony Jimenez-Beristain, Yonglong Dang, Mei Zhong, Petra Kukanja, Shuozhen Bao, Shaohui Wang, Xinyi Lisa Chen, Fu Gao, Dejiang Wang, Hang Xu, Cong Ma, Xing Lou, Yang Liu, Jinmiao Chen, Nenad Sestan, Per Uhl\u00e9n, Arnold Kriegstein, Hongyu Zhao, Gon\u00e7alo Castelo-Branco, Rong Fan, Nature, online 5 november 2025, doi: 10.1038\/s41586-025-09663-y.<\/p>\n","protected":false},"excerpt":{"rendered":"Bild: Rubrik: Di Zhang och Rong Fan, forskare vid Yale University. Foto: Yale University \u2013 Det var \u00f6verraskande…\n","protected":false},"author":2,"featured_media":73235,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69],"tags":[113,112,34,31,33,32,30],"class_list":{"0":"post-73234","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-halsa","8":"tag-halsa","9":"tag-health","10":"tag-se","11":"tag-svenska","12":"tag-sverige","13":"tag-sweden","14":"tag-swedish"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@se\/115498058066200083","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/posts\/73234","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/comments?post=73234"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/posts\/73234\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/media\/73235"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/media?parent=73234"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/categories?post=73234"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/tags?post=73234"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}