{"id":77842,"date":"2025-11-11T13:28:10","date_gmt":"2025-11-11T13:28:10","guid":{"rendered":"https:\/\/www.europesays.com\/se\/77842\/"},"modified":"2025-11-11T13:28:10","modified_gmt":"2025-11-11T13:28:10","slug":"ny-studie-avslojar-ovantad-diversifiering-av-blodstamceller","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/se\/77842\/","title":{"rendered":"Ny studie avsl\u00f6jar ov\u00e4ntad diversifiering av blodstamceller"},"content":{"rendered":"<p>Bild:<\/p>\n<p> <img decoding=\"async\" src=\"https:\/\/www.europesays.com\/se\/wp-content\/uploads\/2025\/11\/JacobsenStenEirik_custom20251111081457.webp.webp\" alt=\"Sten Eirik Jacobsen.\"\/><\/p>\n<p>Rubrik:<\/p>\n<p> Professor Sten Eirik Jacobsen, institutionen f\u00f6r cell- och molekyl\u00e4rbiologi och institutionen f\u00f6r medicin, Huddinge.<br \/>\nFoto: Magnus Bergstr\u00f6m<\/p>\n<p>&#8211; Vi blev entusiastiska n\u00e4r vi ins\u00e5g att vi kunde anv\u00e4nda naturligt f\u00f6rekommande mutationer i m\u00e4nskliga blodstamceller f\u00f6r att kartl\u00e4gga deras bidrag till olika blodlinjer, och \u00e4nnu mer n\u00e4r vi s\u00e5g att m\u00f6nstren f\u00f6r blodlinjef\u00f6rnyelse fr\u00e5n m\u00e4nskliga stamceller matchade dem vi tidigare observerat hos m\u00f6ss\u201d, s\u00e4ger <a href=\"https:\/\/ki.se\/personer\/sten-eirik-jacobsen#about-me\" rel=\"nofollow noopener\" target=\"_blank\">Sten Eirik Jacobsen, professor i stamcellsbiologi och regenerativ medicin<\/a> vid institutionen f\u00f6r cell- och molekyl\u00e4rbiologi samt institutionen f\u00f6r medicin, Huddinge och ledare f\u00f6r <a href=\"https:\/\/ki.se\/forskning\/forskningsomraden-centrum-och-natverk\/forskargrupper\/blodets-stamceller-hos-friska-och-sjuka-sten-eirik-w-jacobsen-forskargrupp\" rel=\"nofollow noopener\" target=\"_blank\">Hematopoietic Stem Cell Biology Group<\/a>.<\/p>\n<p>\u00c4ven efter transplantation f\u00f6rblev dessa m\u00f6nster of\u00f6r\u00e4ndrade, vilket indikerar att de \u00e4r stabila och inneboende programmerade. Avancerad retrospektiv fylogenetisk analys bekr\u00e4ftade att de flesta stamceller beh\u00e5ller sina linjem\u00f6nster i \u00e5rtionden, \u00e4ven om vissa blir mer begr\u00e4nsade med \u00e5ldern. Upprepade benm\u00e4rgsanalyser under fem \u00e5r f\u00f6rst\u00e4rkte denna l\u00e5ngsiktiga stabilitet.<\/p>\n<p><strong>Varf\u00f6r \u00e4r detta viktigt?<\/strong><\/p>\n<p>Uppt\u00e4ckten kan f\u00f6r\u00e4ndra hur man stimulerar blodproduktion efter benm\u00e4rgstransplantation eller cellgiftsbehandling och f\u00f6rb\u00e4ttra behandlingen av sjukdomar d\u00e4r blodbildningen \u00e4r st\u00f6rd. Dessutom \u00e4r kunskap om vilka stamceller som kan utvecklas till cancer avg\u00f6rande f\u00f6r att hitta nya m\u00e5ltavlor f\u00f6r behandling av blodcancer.<\/p>\n<p>Publikation<\/p>\n<p>&#8221;<a href=\"https:\/\/www.nature.com\/articles\/s41588-025-02405-w\" rel=\"nofollow noopener\" target=\"_blank\">Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis<\/a>&#8221;, Tetsuichi Yoshizato, Christer Nilsson, Francesca Grasso, Kari H\u00f6gstrand, Stefania Mazzi, Axel Winroth, Madeleine Lehander, Indira Barbosa, Gunilla Waldin, Teresa Mortera-Blanco, Monika Jansson, Mikaela Hillberg Widfeldt, Affaf Aliouat, Margs S. Brennan, Ellen Markljung, Amy Hillen, Edwin Chari, Eva Hellstr\u00f6m-Lindberg, Warren W. Kretzschmar, Petter S. Woll &amp; Sten Eirik W. Jacobsen<\/p>\n<p>Nature Genetics, 2025 Nov<\/p>\n","protected":false},"excerpt":{"rendered":"Bild: Rubrik: Professor Sten Eirik Jacobsen, institutionen f\u00f6r cell- och molekyl\u00e4rbiologi och institutionen f\u00f6r medicin, Huddinge. Foto: Magnus&hellip;\n","protected":false},"author":2,"featured_media":77843,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69],"tags":[113,112,34,31,33,32,30],"class_list":{"0":"post-77842","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-halsa","8":"tag-halsa","9":"tag-health","10":"tag-se","11":"tag-svenska","12":"tag-sverige","13":"tag-sweden","14":"tag-swedish"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@se\/115531304426541545","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/posts\/77842","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/comments?post=77842"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/posts\/77842\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/media\/77843"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/media?parent=77842"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/categories?post=77842"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/tags?post=77842"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}