{"id":91901,"date":"2025-11-28T08:42:07","date_gmt":"2025-11-28T08:42:07","guid":{"rendered":"https:\/\/www.europesays.com\/se\/91901\/"},"modified":"2025-11-28T08:42:07","modified_gmt":"2025-11-28T08:42:07","slug":"upptackt-om-hjarnreceptorer-kan-oppna-for-nya-alzheimerbehandlingar","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/se\/91901\/","title":{"rendered":"Uppt\u00e4ckt om hj\u00e4rnreceptorer kan \u00f6ppna f\u00f6r nya alzheimerbehandlingar"},"content":{"rendered":"

Bild:<\/p>\n

\"Per<\/p>\n

Rubrik:<\/p>\n

Per Nilsson, docent vid avdelningen f\u00f6r neurogeriatrik, NVS.
\nFoto: Erik Cronberg<\/p>\n

\u2013 V\u00e5ra fynd visar att hj\u00e4rnans eget f\u00f6rsvar mot amyloid-beta kan f\u00f6rst\u00e4rkas genom att stimulera dessa receptorer, s\u00e4ger Per Nilsson<\/a>, docent vid institutionen f\u00f6r neurobiologi, v\u00e5rdvetenskap och samh\u00e4lle<\/a>, Karolinska Institutet.<\/p>\n

I dagsl\u00e4get \u00e4r de mest avancerade alzheimerbehandlingarna baserade p\u00e5 antikroppar. Dessa \u00e4r f\u00f6rknippade med mycket h\u00f6ga kostnader och kan i vissa fall orsaka allvarliga biverkningar.<\/p>\n

\u2013 Om vi i st\u00e4llet kan utveckla sm\u00e5 molekyler som passerar blod-hj\u00e4rnbarri\u00e4ren \u00e4r v\u00e5r f\u00f6rhoppning att vi ska kunna behandla sjukdomen till en betydligt l\u00e4gre kostnad och utan sv\u00e5ra biverkningar, s\u00e4ger Per Nilsson.<\/p>\n

SST1 och SST4 \u00e4r s\u00e5 kallade G-proteinkopplade receptorer, som ofta l\u00e4mpar sig v\u00e4l som m\u00e5ltavlor f\u00f6r l\u00e4kemedelsbehandling. L\u00e4kemedel som riktar sig mot G-proteinkopplade receptorer \u00e4r generellt billiga att tillverka och kan tas som tabletter.<\/p>\n

Studien \u00e4r ett samarbete mellan Karolinska Institutet, RIKEN Center for Brain Science i Japan och flera internationella universitet. Forskningen har finansierats av bland annat Vetenskapsr\u00e5det, H\u00e5llsten Research Foundation, Alzheimerfonden och det privata initiativet Innovativa s\u00e4tt att bota Alzheimers. Forskarna rapporterar inga intressekonflikter.<\/p>\n

Publikation<\/p>\n

Somatostatin receptor subtypes 1 and 4 regulate neprilysin, the major amyloid-\u03b2 degrading enzyme in brain.<\/a>
Nilsson P, S\u00f6rgjerd K, Kakiya N, Sasaguri H, Watamura N, Johansson L, Shimozawa M, Tsubuki S, Zhou Z, Loera-Valencia R, Takamura R, Sekiguchi M, Pegel A, Schulz S, Saito T, Iwata N, Winblad B, Saido TC
J Alzheimers Dis 2025 Nov;():13872877251392782<\/p>\n","protected":false},"excerpt":{"rendered":"Bild: Rubrik: Per Nilsson, docent vid avdelningen f\u00f6r neurogeriatrik, NVS. Foto: Erik Cronberg \u2013 V\u00e5ra fynd visar att…\n","protected":false},"author":2,"featured_media":91902,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69],"tags":[113,112,34,31,33,32,30],"class_list":{"0":"post-91901","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-halsa","8":"tag-halsa","9":"tag-health","10":"tag-se","11":"tag-svenska","12":"tag-sverige","13":"tag-sweden","14":"tag-swedish"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@se\/115626439194556875","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/posts\/91901","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/comments?post=91901"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/posts\/91901\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/media\/91902"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/media?parent=91901"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/categories?post=91901"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/se\/wp-json\/wp\/v2\/tags?post=91901"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}