TN.cz<\/a>, vedcom sa podarilo odhali\u0165 takzvan\u00fd bod zlomu bunky \u2013 okamih, ke\u010f sa za\u010d\u00edna meni\u0165 jej spr\u00e1vanie sp\u00f4sobom, ktor\u00fd m\u00f4\u017ee vies\u0165 k rozvoju n\u00e1dorov\u00e9ho ochorenia.<\/p>\nV\u00fdsledky v\u00fdskumu vzbudili pozornos\u0165 aj v zahrani\u010d\u00ed a publikoval ich prest\u00ed\u017eny vedeck\u00fd \u010dasopis Science Advances.<\/p>\n
Rozhoduj\u00facu \u00falohu zohr\u00e1va komunik\u00e1cia medzi bunkami<\/p>\n
Hoci vznik rakoviny vedci sk\u00famaj\u00fa desa\u0165ro\u010dia, mnoh\u00e9 mechanizmy zost\u00e1vali doteraz neobjasnen\u00e9. Zjednodu\u0161ene povedan\u00e9, n\u00e1dor vznik\u00e1 vtedy, ke\u010f po\u0161koden\u00e1 bunka nezanikne prirodzen\u00fdm sp\u00f4sobom, ale za\u010dne sa nekontrolovane deli\u0165 a prestane spr\u00e1vne spolupracova\u0165 s ostatn\u00fdmi bunkami organizmu.<\/p>\n
Pr\u00e1ve t\u00e1to vz\u00e1jomn\u00e1 komunik\u00e1cia je pod\u013ea \u010desk\u00fdch vedcov mimoriadne d\u00f4le\u017eit\u00e1. K\u013e\u00fa\u010dov\u00fa \u00falohu pritom zohr\u00e1va takzvan\u00e1 signaliza\u010dn\u00e1 dr\u00e1ha WNT, ktor\u00e1 koordinuje fungovanie mili\u00e1rd buniek v \u013eudskom tele. V\u00fdskumn\u00fd t\u00edm zistil, \u017ee bunky na prijat\u00e9 sign\u00e1ly nereaguj\u00fa postupne, ale funguj\u00fa podobne ako vyp\u00edna\u010d \u2013 bu\u010f sa aktivuj\u00fa, alebo zostan\u00fa neakt\u00edvne.<\/p>\n
Rozhoduje jedin\u00fd prote\u00edn<\/p>\n
Prv\u00fd autor \u0161t\u00fadie Miroslav Micka vysvetlil, \u017ee rozhoduj\u00facu \u00falohu zohr\u00e1va prote\u00edn DVL. \u201eZistili sme, \u017ee prote\u00edn DVL sa spr\u00e1va ako prep\u00edna\u010d. Svoju \u0161trukt\u00faru zmen\u00ed a\u017e vo chv\u00edli, ke\u010f z\u00e1porn\u00fd n\u00e1boj na jeho povrchu prekro\u010d\u00ed ur\u010dit\u00fa prahov\u00fa hodnotu. A\u017e potom sa prestav\u00ed a umo\u017en\u00ed \u010fal\u0161\u00ed krok pri prenose sign\u00e1lu,\u201c citovala jeho vyjadrenie TN.cz.<\/p>\n
Pr\u00e1ve tento mechanizmus pod\u013ea vedcov predstavuje d\u00f4le\u017eit\u00fd moment, ktor\u00fd m\u00f4\u017ee rozhodova\u0165 o \u010fal\u0161om spr\u00e1van\u00ed bunky.<\/p>\n
Objav m\u00f4\u017ee pom\u00f4c\u0165 pri v\u00fdvoji novej lie\u010dby<\/p>\n
Pod\u013ea odborn\u00edkov vznikaj\u00fa v \u013eudskom organizme ka\u017ed\u00fd de\u0148 tis\u00edce po\u0161koden\u00fdch buniek. M\u00f4\u017eu by\u0165 d\u00f4sledkom prirodzen\u00fdch ch\u00fdb pri delen\u00ed buniek alebo p\u00f4sobenia vonkaj\u0161\u00edch faktorov, napr\u00edklad \u0161kodliv\u00e9ho \u017eiarenia \u010di chemick\u00fdch l\u00e1tok.<\/p>\n
Vo v\u00e4\u010d\u0161ine pr\u00edpadov ich v\u0161ak imunitn\u00fd syst\u00e9m dok\u00e1\u017ee rozpozna\u0165 a odstr\u00e1ni\u0165 sk\u00f4r, ne\u017e sp\u00f4sobia v\u00e1\u017enej\u0161\u00ed probl\u00e9m.<\/p>\n
Lek\u00e1r Cyril Mucha pre TN.cz vysvetlil, \u017ee pod\u013ea jednej z odborn\u00fdch te\u00f3ri\u00ed prekon\u00e1 ka\u017ed\u00fd \u010dlovek po\u010das \u017eivota vznik rakovinov\u00fdch buniek viackr\u00e1t, no zdrav\u00e1 imunita ich dok\u00e1\u017ee zlikvidova\u0165 e\u0161te v z\u00e1rodku.<\/p>\n
\u201eHovor\u00ed sa, \u017ee ide vlastne o poruchu imunity. Ka\u017ed\u00fd z n\u00e1s m\u00f4\u017ee po\u010das \u017eivota opakovane vytvori\u0165 rakovinov\u00e9 bunky, ale spr\u00e1vne funguj\u00faci imunitn\u00fd syst\u00e9m ich odstr\u00e1ni. A\u017e ke\u010f to z r\u00f4znych d\u00f4vodov nedok\u00e1\u017ee, rakovina sa za\u010dne rozv\u00edja\u0165,\u201c uviedol.<\/p>\n
Vedci sa odpove\u010f sna\u017eili n\u00e1js\u0165 cel\u00e9 roky<\/p>\n
Moment, ke\u010f sa zdrav\u00e1 bunka za\u010dne meni\u0165 na n\u00e1dorov\u00fa, patr\u00ed medzi najv\u00e4\u010d\u0161ie ot\u00e1zky modernej onkol\u00f3gie. Odborn\u00e9 t\u00edmy po celom svete sa jeho mechanizmus sna\u017eili objasni\u0165 dlh\u00e9 roky.<\/p>\n
Brnianski vedci teraz veria, \u017ee ich objav pom\u00f4\u017ee lep\u0161ie pochopi\u0165 vznik rakoviny a v bud\u00facnosti m\u00f4\u017ee prispie\u0165 aj k v\u00fdvoju \u00fa\u010dinnej\u0161\u00edch sp\u00f4sobov prevencie alebo lie\u010dby tohto z\u00e1va\u017en\u00e9ho ochorenia.<\/p>\n","protected":false},"excerpt":{"rendered":"BRNO – Vedci z Brna ozn\u00e1mili objav, ktor\u00fd m\u00f4\u017ee v\u00fdrazne posun\u00fa\u0165 v\u00fdskum rakoviny. Podarilo sa im identifikova\u0165 mechanizmus,…\n","protected":false},"author":2,"featured_media":140319,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_share_on_mastodon":"0"},"categories":[8],"tags":[2387,43504,33,5887,1793,1629,43,40,42,36,50,43505,49,48],"class_list":["post-140318","post","type-post","status-publish","format-standard","has-post-thumbnail","category-svet","tag-brno","tag-ceski-vedci","tag-news","tag-objav","tag-odhalenie","tag-rakovina","tag-sk","tag-slovak","tag-slovencina","tag-spravy","tag-svet","tag-vznik-rakoviny","tag-world","tag-world-news"],"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@sk\/117029665879142227","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/posts\/140318","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/comments?post=140318"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/posts\/140318\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/media\/140319"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/media?parent=140318"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/categories?post=140318"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/tags?post=140318"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}