Biomarker Research<\/a> nazna\u010duj\u00fa, \u017ee met\u00f3da dosahuje ve\u013emi vysok\u00fa presnos\u0165 a z\u00e1rove\u0148 je pre pacientov podstatne \u0161etrnej\u0161ia.<\/p>\nRakovina sa \u010dasto odhal\u00ed neskoro<\/p>\n
Rakovina \u00fastnej dutiny patr\u00ed medzi ochorenia, pri ktor\u00fdch zohr\u00e1va skor\u00e1 diagnostika rozhoduj\u00facu \u00falohu. Ka\u017ed\u00fd rok postihne pod\u013ea odborn\u00edkov pribli\u017ene 650-tis\u00edc \u013eud\u00ed na celom svete, pri\u010dom ve\u013ek\u00e1 \u010das\u0165 pr\u00edpadov sa zachyt\u00ed a\u017e v pokro\u010dilom \u0161t\u00e1diu. Medzi prv\u00e9 pr\u00edznaky patria nehojace sa ranky, biele alebo \u010derven\u00e9 \u0161kvrny \u010di zmeny na jazyku, \u010fasn\u00e1ch alebo vn\u00fatornej strane l\u00edc.<\/p>\n
Definit\u00edvne potvrdenie diagn\u00f3zy si dnes vo v\u00e4\u010d\u0161ine pr\u00edpadov vy\u017eaduje biopsiu \u2013 chirurgick\u00fd odber vzorky tkaniva. Ke\u010f\u017ee ide o nepr\u00edjemn\u00fd z\u00e1krok, niektor\u00ed pacienti odkladaj\u00fa kontroln\u00e9 vy\u0161etrenia alebo ich \u00faplne vynechaj\u00fa.<\/p>\n
Sta\u010d\u00ed jemn\u00fd v\u00fdter<\/p>\n
Nov\u00e1 met\u00f3da s n\u00e1zvom qMIDS funguje podstatne jednoduch\u0161ie. Lek\u00e1r pomocou malej kefky odoberie bunky z podozriv\u00e9ho miesta aj zo zdravej \u010dasti \u00fastnej dutiny. Laborat\u00f3rium n\u00e1sledne analyzuje aktivitu \u0161tyroch g\u00e9nov, ktor\u00e9 s\u00fa spojen\u00e9 so vznikom rakoviny \u00fastnej dutiny.<\/p>\n
V\u00fdhodou je, \u017ee cel\u00fd proces je neinvaz\u00edvny a v\u00fdsledok m\u00f4\u017ee by\u0165 k dispoz\u00edcii pribli\u017ene do jednej hodiny.<\/p>\n
Presnos\u0165 presiahla 95 percent<\/p>\n
Do \u0161t\u00fadie sa zapojilo 545 pacientov, od ktor\u00fdch vedci analyzovali viac ne\u017e tis\u00edc odobrat\u00fdch vzoriek. Nov\u00fd test dosiahol celkov\u00fa presnos\u0165 95,5 percenta, pri\u010dom podiel falo\u0161ne pozit\u00edvnych aj falo\u0161ne negat\u00edvnych v\u00fdsledkov zostal pod piatimi percentami.<\/p>\n
Pod\u013ea autorov ide o najv\u00e4\u010d\u0161ie klinick\u00e9 hodnotenie tejto met\u00f3dy, ak\u00e9 bolo doteraz uskuto\u010dnen\u00e9.<\/p>\n
\u201eTento test poskytuje lek\u00e1rom r\u00fdchly, presn\u00fd a neinvaz\u00edvny sp\u00f4sob, ako pos\u00fadi\u0165 riziko u pacientov. Ve\u013ekou v\u00fdhodou je, \u017ee ho mo\u017eno opakovane pou\u017e\u00edva\u0165 pri dlhodobom sledovan\u00ed \u013eud\u00ed s prekancer\u00f3znymi zmenami a zachyti\u0165 rakovinu ove\u013ea sk\u00f4r,\u201c uviedol ved\u00faci v\u00fdskumu Muy-Teck Teh z Queen Mary University of London.<\/p>\n
Vedcov prekvapilo, \u017ee v\u00fdsledky boli porovnate\u013en\u00e9 s ove\u013ea invaz\u00edvnej\u0161ou mikrobiopsiou. \u201eBoli sme \u00faprimne prekvapen\u00ed, \u017ee v\u00fdter dosiahol porovnate\u013en\u00fa \u00faspe\u0161nos\u0165. Znamen\u00e1 to, \u017ee biologick\u00fd sign\u00e1l t\u00fdchto \u0161tyroch g\u00e9nov je dostato\u010dne siln\u00fd na to, aby sa dal spo\u013eahlivo zachyti\u0165 aj z buniek odobrat\u00fdch z povrchu sliznice,\u201c vysvetlil Teh.<\/p>\n
M\u00f4\u017ee zn\u00ed\u017ei\u0165 po\u010det zbyto\u010dn\u00fdch biopsi\u00ed<\/p>\n
Vedci odhaduj\u00fa, \u017ee ak sa v\u00fdsledky potvrdia aj v \u010fal\u0161\u00edch klinick\u00fdch sk\u00fa\u0161kach, nov\u00fd test by mohol v\u00fdrazne obmedzi\u0165 po\u010det pacientov, ktor\u00ed bud\u00fa musie\u0165 podst\u00fapi\u0165 invaz\u00edvnu biopsiu. Pod\u013ea autorov by mohol pom\u00f4c\u0165 pred\u00eds\u0165 viac ako 90 percent\u00e1m zbyto\u010dn\u00fdch chirurgick\u00fdch odberov u pacientov s n\u00edzkym rizikom rakoviny.<\/p>\n
Z\u00e1rove\u0148 by umo\u017enil pravidelnej\u0161ie sledovanie \u013eud\u00ed s podozriv\u00fdmi zmenami v \u00fastnej dutine bez opakovan\u00fdch bolestiv\u00fdch z\u00e1krokov.<\/p>\n
Do praxe by sa mohol dosta\u0165 o dva roky<\/p>\n
V\u00fdskumn\u00fd t\u00edm u\u017e pracuje na komercializ\u00e1cii testu qMIDS. Ak \u00faspe\u0161ne prejde \u010fal\u0161\u00edmi klinick\u00fdmi overeniami a z\u00edska potrebn\u00e9 regula\u010dn\u00e9 schv\u00e1lenia, mohol by sa pod\u013ea vedcov za\u010da\u0165 pou\u017e\u00edva\u0165 v nemocniciach pribli\u017ene do dvoch rokov.<\/p>\n
Odborn\u00edci v\u0161ak zd\u00f4raz\u0148uj\u00fa, \u017ee zatia\u013e nejde o n\u00e1hradu v\u0161etk\u00fdch biopsi\u00ed. Nov\u00e1 met\u00f3da by mala sl\u00fa\u017ei\u0165 najm\u00e4 ako r\u00fdchly a \u0161etrn\u00fd sp\u00f4sob v\u010dasn\u00e9ho odhalenia rizikov\u00fdch zmien a v\u00fdberu pacientov, ktor\u00ed potrebuj\u00fa \u010fal\u0161ie podrobn\u00e9 vy\u0161etrenia.<\/p>\n
\n\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"LOND\u00ddN – Oby\u010dajn\u00fd v\u00fdter z \u00fastnej dutiny by mohol v bud\u00facnosti nahradi\u0165 \u010das\u0165 bolestiv\u00fdch biopsi\u00ed pri podozren\u00ed na…\n","protected":false},"author":2,"featured_media":141395,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_share_on_mastodon":"0"},"categories":[8],"tags":[43744,33,1629,43745,43,40,42,36,50,4056,11552,5343,351,43746,49,48],"class_list":["post-141394","post","type-post","status-publish","format-standard","has-post-thumbnail","category-svet","tag-biopsia","tag-news","tag-rakovina","tag-rakovina-ustnej-dutiny","tag-sk","tag-slovak","tag-slovencina","tag-spravy","tag-svet","tag-test","tag-ustna-dutina","tag-vedci","tag-vysetrenie","tag-vyter","tag-world","tag-world-news"],"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@sk\/117036008290323749","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/posts\/141394","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/comments?post=141394"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/posts\/141394\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/media\/141395"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/media?parent=141394"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/categories?post=141394"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/tags?post=141394"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}