SAN DIEGO \u2013 Cukrovka nemus\u00ed vznika\u0165 len preto, \u017ee telo produkuje m\u00e1lo inzul\u00ednu. Vedci teraz objavili d\u00f4le\u017eit\u00fd mechanizmus, ktor\u00fd m\u00f4\u017ee po\u0161kodzova\u0165 bunky pankreasu e\u0161te sk\u00f4r, ne\u017e ochorenie naplno prepukne. Ak sa ich zistenia potvrdia, mohli by otvori\u0165 cestu k \u00faplne nov\u00e9mu sp\u00f4sobu lie\u010dby.<\/p>\n
Vedci urobili objav, ktor\u00fd m\u00f4\u017ee zmeni\u0165 poh\u013ead na vznik cukrovky 2. typu. Zistili, \u017ee probl\u00e9m nemus\u00ed spo\u010d\u00edva\u0165 len v nedostatku inzul\u00ednu, ale aj v tom, \u017ee sa jeho prekurzor nespr\u00e1vne \u201esklad\u00e1\u201c e\u0161te vo vn\u00fatri buniek pankreasu. Tak\u00e9to po\u0161koden\u00e9 bielkoviny n\u00e1sledne bunky pre\u0165a\u017euj\u00fa a postupne zni\u017euj\u00fa ich schopnos\u0165 produkova\u0165 inzul\u00edn.<\/p>\n
Ako informoval Sanford Burnham Prebys Medical Discovery Institute, v\u00fdsledky \u0161t\u00fadie publikovanej v odbornom \u010dasopise Proceedings of the National Academy of Sciences uk\u00e1zali, \u017ee spr\u00e1vne vytv\u00e1ranie inzul\u00ednu z\u00e1vis\u00ed od spolupr\u00e1ce viacer\u00fdch \u0161peci\u00e1lnych bielkov\u00edn. Ak jedna z nich ch\u00fdba, v bunk\u00e1ch sa za\u010dn\u00fa hromadi\u0165 chybne poskladan\u00e9 bielkoviny a produkcia inzul\u00ednu v\u00fdrazne kles\u00e1.<\/p>\n
Probl\u00e9m sa za\u010d\u00edna e\u0161te pred vznikom inzul\u00ednu<\/p>\n
Inzul\u00edn nevznik\u00e1 okam\u017eite. Bunky pankreasu najsk\u00f4r vytvoria l\u00e1tku naz\u00fdvan\u00fa proinzul\u00edn, z ktorej sa n\u00e1sledne vytvor\u00ed samotn\u00fd inzul\u00edn.<\/p>\n
Aby v\u0161etko fungovalo spr\u00e1vne, mus\u00ed sa proinzul\u00edn posklada\u0165 do presn\u00e9ho trojrozmern\u00e9ho tvaru. Ak sa tento proces pokaz\u00ed, vznikaj\u00fa po\u0161koden\u00e9 bielkoviny, ktor\u00e9 sa v bunk\u00e1ch hromadia a vyvol\u00e1vaj\u00fa stres.<\/p>\n
Pr\u00e1ve tento stres m\u00f4\u017ee pod\u013ea vedcov postupne po\u0161kodzova\u0165 beta bunky pankreasu, ktor\u00e9 inzul\u00edn produkuj\u00fa.<\/p>\n
Objavili d\u00f4le\u017eit\u00e9ho \u201epomocn\u00edka\u201c<\/p>\n
V\u00fdskumn\u00edci sk\u00famali bielkovinu BiP, ktor\u00e1 funguje ako ak\u00fdsi molekul\u00e1rny pomocn\u00edk zabezpe\u010duj\u00faci spr\u00e1vne skladanie proinzul\u00ednu.<\/p>\n
Zistili v\u0161ak, \u017ee sama nesta\u010d\u00ed. Rovnako d\u00f4le\u017eit\u00fa \u00falohu zohr\u00e1va \u010fal\u0161ia bielkovina s n\u00e1zvom p58IPK.<\/p>\n
Ke\u010f vedci t\u00fato bielkovinu odstr\u00e1nili z buniek aj z pokusn\u00fdch my\u0161\u00ed, mno\u017estvo nespr\u00e1vne poskladan\u00e9ho proinzul\u00ednu prudko vzr\u00e1stlo. Z\u00e1rove\u0148 sa v\u00fdrazne zn\u00ed\u017eila tvorba inzul\u00ednu.<\/p>\n
Jedna bielkovina nesta\u010d\u00ed<\/p>\n
Vedci n\u00e1sledne sk\u00fa\u0161ali bunk\u00e1m ch\u00fdbaj\u00facu bielkovinu op\u00e4\u0165 doda\u0165. V\u00fdsledky uk\u00e1zali, \u017ee schopnos\u0165 buniek vytv\u00e1ra\u0165 spr\u00e1vny proinzul\u00edn sa v\u00fdrazne zlep\u0161ila. Ak v\u0161ak ch\u00fdbal hlavn\u00fd pomocn\u00edk BiP, pozit\u00edvny efekt sa prakticky neprejavil. Pod\u013ea autorov v\u00fdskumu obe bielkoviny funguj\u00fa ako zohran\u00e1 dvojica.<\/p>\n
\u201eJe to podobn\u00e9, ako keby sa tenista sna\u017eil hra\u0165 \u0161tvorhru \u00faplne s\u00e1m. BiP nedok\u00e1\u017ee zabezpe\u010di\u0165 spr\u00e1vne skladanie proinzul\u00ednu bez svojho partnera p58IPK,\u201c vysvetlila hlavn\u00e1 autorka \u0161t\u00fadie Insook Jangov\u00e1.<\/p>\n
Nov\u00e1 n\u00e1dej pre lie\u010dbu cukrovky<\/p>\n
S\u00fa\u010dasn\u00e9 lieky na cukrovku sa zameriavaj\u00fa najm\u00e4 na zni\u017eovanie hladiny cukru v krvi alebo podporu uvo\u013e\u0148ovania inzul\u00ednu.<\/p>\n
Nov\u00fd objav v\u0161ak nazna\u010duje, \u017ee by bolo mo\u017en\u00e9 zasiahnu\u0165 e\u0161te sk\u00f4r \u2013 ochr\u00e1ni\u0165 samotn\u00e9 bunky pankreasu pred po\u0161koden\u00edm a zachova\u0165 ich schopnos\u0165 vytv\u00e1ra\u0165 inzul\u00edn.<\/p>\n
\u201eAk sa nau\u010d\u00edme ovplyvni\u0165 \u010dinnos\u0165 bielkoviny BiP a jej partnerov, mohli by sme n\u00e1js\u0165 nov\u00fd sp\u00f4sob, ako predch\u00e1dza\u0165 po\u0161kodeniu buniek produkuj\u00facich inzul\u00edn e\u0161te v po\u010diato\u010dn\u00fdch \u0161t\u00e1di\u00e1ch cukrovky,\u201c uviedol profesor Randal J. Kaufman, ktor\u00fd v\u00fdskum viedol.<\/p>\n
Cesta k nov\u00fdm liekom je e\u0161te dlh\u00e1<\/p>\n
Vedci upozor\u0148uj\u00fa, \u017ee ide zatia\u013e o z\u00e1kladn\u00fd laborat\u00f3rny v\u00fdskum. Objav s\u00edce otv\u00e1ra nov\u00e9 mo\u017enosti, no bude potrebn\u00fdch e\u0161te mnoho \u010fal\u0161\u00edch \u0161t\u00fadi\u00ed, aby sa potvrdilo, \u010di mo\u017eno tento mechanizmus vyu\u017ei\u0165 aj pri v\u00fdvoji nov\u00fdch liekov pre pacientov.<\/p>\n
Ak sa to podar\u00ed, bud\u00faca lie\u010dba cukrovky by sa nemusela zameriava\u0165 len na zvl\u00e1danie n\u00e1sledkov ochorenia, ale aj na ochranu buniek pankreasu e\u0161te pred ich nezvratn\u00fdm po\u0161koden\u00edm.
\n\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"SAN DIEGO \u2013 Cukrovka nemus\u00ed vznika\u0165 len preto, \u017ee telo produkuje m\u00e1lo inzul\u00ednu. Vedci teraz objavili d\u00f4le\u017eit\u00fd mechanizmus,…\n","protected":false},"author":2,"featured_media":143195,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_share_on_mastodon":"0"},"categories":[8],"tags":[7668,4524,33,5887,39744,43,40,42,36,50,5343,49,48],"class_list":["post-143194","post","type-post","status-publish","format-standard","has-post-thumbnail","category-svet","tag-cukrovka","tag-liecba","tag-news","tag-objav","tag-pricina","tag-sk","tag-slovak","tag-slovencina","tag-spravy","tag-svet","tag-vedci","tag-world","tag-world-news"],"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@sk\/117046691964532837","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/posts\/143194","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/comments?post=143194"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/posts\/143194\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/media\/143195"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/media?parent=143194"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/categories?post=143194"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/tags?post=143194"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}