LOND\u00ddN \u2013 Vedci urobili objav, ktor\u00fd by mohol v\u00fdrazne posun\u00fa\u0165 v\u00fdvoj lie\u010dby Alzheimerovej choroby. Po prv\u00fdkr\u00e1t identifikovali doteraz nezn\u00e1my mechanizmus, ktor\u00fdm odumieraj\u00fa mozgov\u00e9 bunky. Ak sa ho podar\u00ed zastavi\u0165, mohol by spomali\u0165 postup jedn\u00e9ho z naj\u010dastej\u0161\u00edch neurodegenerat\u00edvnych ochoren\u00ed.<\/p>\n
Alzheimerova choroba aj frontotempor\u00e1lna demencia patria medzi ochorenia, pri ktor\u00fdch postupne odumieraj\u00fa nervov\u00e9 bunky v mozgu. Vedci s\u00edce u\u017e desa\u0165ro\u010dia vedeli, \u017ee v mozgu pacientov sa hromadia \u0161kodliv\u00e9 bielkoviny, no presn\u00fd mechanizmus, ktor\u00fdm bunky hyn\u00fa, zost\u00e1val z\u00e1hadou. Ako informoval port\u00e1l ScienceDaily, v\u00fdskumn\u00edci z King’s College London teraz objavili d\u00f4le\u017eit\u00fd \u010dl\u00e1nok tejto sklada\u010dky.<\/p>\n
Objavili dovtedy nezn\u00e1my mechanizmus<\/p>\n
Vedci identifikovali proces naz\u00fdvan\u00fd karyopt\u00f3za, ktor\u00fd m\u00f4\u017ee zohr\u00e1va\u0165 k\u013e\u00fa\u010dov\u00fa \u00falohu pri odumieran\u00ed mozgov\u00fdch buniek. Ide o s\u00e9riu chemick\u00fdch reakci\u00ed, ktor\u00e9 sa spustia po nahromaden\u00ed toxick\u00fdch bielkov\u00edn v nervov\u00fdch bunk\u00e1ch. Tie postupne po\u0161kodzuj\u00fa bunkov\u00e9 jadro obsahuj\u00face genetick\u00fa inform\u00e1ciu. Jadro sa za\u010dne zmen\u0161ova\u0165, str\u00e1ca svoju \u0161trukt\u00faru a napokon sa \u00faplne rozpadne, \u010do vedie k smrti bunky.<\/p>\n
V\u00fdsledky v\u00fdskumu publikovan\u00e9ho v \u010dasopise Nature Communications vych\u00e1dzaj\u00fa z anal\u00fdzy pribli\u017ene 3 000 mozgov\u00fdch buniek od 28 pacientov s Alzheimerovou chorobou alebo frontotempor\u00e1lnou demenciou. Vedci zistili, \u017ee zn\u00e1mky karyopt\u00f3zy sa nach\u00e1dzali a\u017e v 35 percent\u00e1ch buniek pacientov s Alzheimerovou chorobou, zatia\u013e \u010do u zdrav\u00fdch star\u0161\u00edch \u013eud\u00ed ich na\u0161li len pribli\u017ene v 15 percent\u00e1ch buniek.<\/p>\n
Bielkoviny sp\u00fa\u0161\u0165aj\u00fa re\u0165azov\u00fa reakciu<\/p>\n
V\u00fdskumn\u00edci z\u00e1rove\u0148 odhalili molekul\u00e1rnu dr\u00e1hu, ktor\u00e1 cel\u00fd proces riadi. Zistili, \u017ee zhlukovanie toxick\u00fdch bielkov\u00edn nar\u00fa\u0161a vonkaj\u0161\u00ed obal bunkov\u00e9ho jadra. To n\u00e1sledne vedie k jeho postupn\u00e9mu rozpadu.<\/p>\n
V laborat\u00f3rnych pokusoch na neur\u00f3noch potkanov sa vedcom podarilo tento proces \u010diasto\u010dne utlmi\u0165 zablokovan\u00edm \u0161peci\u00e1lnych bielkov\u00edn naz\u00fdvan\u00fdch kin\u00e1zy. Najv\u00e4\u010d\u0161iu pozornos\u0165 vzbudila interakcia medzi enz\u00fdmom p38 MAP kin\u00e1za a bielkovinou LaminB1, ktor\u00e1 by sa v bud\u00facnosti mohla sta\u0165 cie\u013eom nov\u00fdch liekov.<\/p>\n
Nov\u00e1 n\u00e1dej pre pacientov<\/p>\n
Pod\u013ea ved\u00faceho v\u00fdskumu Dr. Manolisa Fanta by zacielenie na tento mechanizmus mohlo spomali\u0165 odumieranie mozgov\u00fdch buniek a z\u00edska\u0165 tak viac \u010dasu na lie\u010dbu samotn\u00e9ho ochorenia.<\/p>\n
Autori \u0161t\u00fadie zd\u00f4raz\u0148uj\u00fa, \u017ee nejde o objav nov\u00e9ho lieku, ale o v\u00fdznamn\u00fd krok k lep\u0161iemu pochopeniu Alzheimerovej choroby. Ak sa podar\u00ed tento mechanizmus potvrdi\u0165 aj v \u010fal\u0161\u00edch v\u00fdskumoch, m\u00f4\u017ee sa sta\u0165 z\u00e1kladom pre v\u00fdvoj terapi\u00ed, ktor\u00e9 bud\u00fa schopn\u00e9 spomali\u0165 priebeh ochorenia e\u0161te pred nezvratn\u00fdm po\u0161koden\u00edm mozgu.<\/p>\n
Ved\u00faca autorka \u0161t\u00fadie Dr. Rebecca Castertonov\u00e1 uviedla, \u017ee v\u00fdskumn\u00edci teraz vytvorili ak\u00fasi \u201emapu\u201c procesu, ktor\u00fdm mozgov\u00e9 bunky odumieraj\u00fa. Pr\u00e1ve t\u00e1 by mohla v bud\u00facnosti pom\u00f4c\u0165 vedcom vyv\u00edja\u0165 \u00fa\u010dinnej\u0161ie lieky proti demencii.<\/p>\n
Odborn\u00edci z\u00e1rove\u0148 upozor\u0148uj\u00fa, \u017ee hoci s\u00fa v\u00fdsledky ve\u013emi s\u013eubn\u00e9, ide zatia\u013e o laborat\u00f3rny v\u00fdskum. Bude potrebn\u00fdch e\u0161te nieko\u013eko rokov \u010fal\u0161\u00edch \u0161t\u00fadi\u00ed, k\u00fdm sa uk\u00e1\u017ee, \u010di sa nov\u00fd objav podar\u00ed pretavi\u0165 do lie\u010dby pacientov. Napriek tomu ide pod\u013ea vedcov o jeden z najv\u00fdznamnej\u0161\u00edch objavov v oblasti v\u00fdskumu Alzheimerovej choroby za posledn\u00e9 roky.<\/p>\n","protected":false},"excerpt":{"rendered":"LOND\u00ddN \u2013 Vedci urobili objav, ktor\u00fd by mohol v\u00fdrazne posun\u00fa\u0165 v\u00fdvoj lie\u010dby Alzheimerovej choroby. Po prv\u00fdkr\u00e1t identifikovali doteraz…\n","protected":false},"author":2,"featured_media":149881,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_share_on_mastodon":"0"},"categories":[8],"tags":[22949,743,33,43,40,42,36,50,5343,49,48],"class_list":["post-149880","post","type-post","status-publish","format-standard","has-post-thumbnail","category-svet","tag-alzheimerova-choroba","tag-mozog","tag-news","tag-sk","tag-slovak","tag-slovencina","tag-spravy","tag-svet","tag-vedci","tag-world","tag-world-news"],"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@sk\/117087338630194473","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/posts\/149880","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/comments?post=149880"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/posts\/149880\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/media\/149881"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/media?parent=149880"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/categories?post=149880"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/tags?post=149880"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}