{"id":38757,"date":"2026-04-07T20:46:09","date_gmt":"2026-04-07T20:46:09","guid":{"rendered":"https:\/\/www.europesays.com\/sk\/38757\/"},"modified":"2026-04-07T20:46:09","modified_gmt":"2026-04-07T20:46:09","slug":"baxdrostat-je-novy-liek-ktory-dokaze-znizit-krvny-tlak-ak-ziadna-bezna-liecba-uz-nezabera-vosveteit-sk","status":"publish","type":"post","link":"https:\/\/www.europesays.com\/sk\/38757\/","title":{"rendered":"Baxdrostat je nov\u00fd liek, ktor\u00fd dok\u00e1\u017ee zn\u00ed\u017ei\u0165 krvn\u00fd tlak, ak \u017eiadna be\u017en\u00e1 lie\u010dba u\u017e nezaber\u00e1 | Vosveteit.sk"},"content":{"rendered":"

Vysok\u00fd krvn\u00fd tlak<\/a> patr\u00ed medzi najroz\u0161\u00edrenej\u0161ie zdravotn\u00e9 probl\u00e9my dne\u0161ka. Postihuje pribli\u017ene 1,3 miliardy \u013eud\u00ed a u ve\u013ekej \u010dasti z nich lie\u010dba<\/a> nezaber\u00e1 tak, ako by mala. Pr\u00e1ve pre t\u00fato skupinu teraz prich\u00e1dza nov\u00fd liek, ktor\u00fd ide na probl\u00e9m \u00faplne inak.<\/p>\n

Vol\u00e1 sa baxdrostat a u\u017e\u00edva sa ako jednoduch\u00e1 tabletka raz denne, informuje Science Daily.<\/a> Od in\u00fdch liekov sa l\u00ed\u0161i t\u00fdm, \u017ee sa vedci tentoraz zamerali na samotn\u00fd zdroj probl\u00e9mu, nie len na jeho n\u00e1sledky. A pr\u00e1ve to rob\u00ed z tejto novinky zauj\u00edmav\u00fd kandid\u00e1t na v\u00fdrazn\u00fd posun v lie\u010dbe.<\/p>\n

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Ve\u013ek\u00e1 medzin\u00e1rodn\u00e1 \u0161t\u00fadia sledovala takmer 800 pacientov, ktor\u00fdm vysok\u00fd tlak ne\u0161lo dosta\u0165 pod kontrolu ani kombin\u00e1ciou viacer\u00fdch liekov. Po 12 t\u00fd\u017ed\u0148och sa uk\u00e1zal rozdiel, ktor\u00fd si zasl\u00fa\u017ei pozornos\u0165. Pacienti s baxdrostatom mali tlak ni\u017e\u0161\u00ed pribli\u017ene o 9 a\u017e 10 mmHg oproti skupine s placebom.<\/p>\n

Nov\u00fd liek baxdrostat uk\u00e1zal, \u017ee skuto\u010dne funguje, ak in\u00e9 lie\u010dby nezaberaj\u00fa<\/p>\n

Na prv\u00fd poh\u013ead to p\u00f4sob\u00ed ako mal\u00e1 zmena, no trval\u00e9 zn\u00ed\u017eenie tlaku o 10 mmHg znamen\u00e1 pribli\u017ene o 27 % ni\u017e\u0161ie riziko mozgovej pr\u00edhody<\/a>, o 28 % ni\u017e\u0161ie riziko zlyhania srdca a o 13 % ni\u017e\u0161ie riziko \u00famrtia na srdcovo-cievne ochorenia. In\u00fdmi slovami, ide o rozdiel, ktor\u00fd m\u00f4\u017ee re\u00e1lne zachra\u0148ova\u0165 \u017eivoty.<\/p>\n

\"tabletky\"tabletkyZdroj: vsurkov \/ depositphotos.com<\/a><\/p>\n

\u201eZn\u00ed\u017eenie systolick\u00e9ho tlaku takmer o 10 mmHg je ve\u013emi povzbudiv\u00e9, preto\u017ee sa sp\u00e1ja s v\u00fdrazne ni\u017e\u0161\u00edm rizikom infarktu, m\u0155tvice \u010di zlyhania srdca,\u201c vysvetlil profesor Bryan Williams.<\/p>\n

Takmer 40 % pacientov sa dostalo na zdrav\u00e9 hodnoty tlaku, pri\u010dom v\u00a0skupine bez lieku to nedosiahla ani p\u00e4tina. To znamen\u00e1, \u017ee liek fungoval v\u00fdrazne lep\u0161ie ne\u017e samotn\u00e1 \u0161tandardn\u00e1 lie\u010dba.<\/p>\n

Neprehliadni
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\"Tvoje\"Tvoje <\/p>\n

\n\t\t\t\t\tPopul\u00e1rna spravodajsk\u00e1 aplik\u00e1cia pre iOS a Android dostala ve\u013ek\u00fa aktualiz\u00e1ciu. Pribudlo mno\u017estvo nov\u00fdch funkci\u00ed, ktor\u00e9 mus\u00ed\u0161 vysk\u00fa\u0161a\u0165 <\/p>\n

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Rozdiel spo\u010d\u00edva v tom, ako baxdrostat zasahuje do fungovania tela. V\u00e4\u010d\u0161ina dne\u0161n\u00fdch liekov blokuje \u00fa\u010dinok horm\u00f3nu aldoster\u00f3nu a\u017e na konci procesu,\u00a0teda na receptoroch. Predstav si to ako snahu zachyt\u00e1va\u0165 vodu, ktor\u00e1 u\u017e te\u010die z koh\u00fatika.<\/p>\n

Baxdrostat pracuje s procesom, ktor\u00fd sa deje e\u0161te krok predt\u00fdm<\/p>\n

Baxdrostat ide o krok sp\u00e4\u0165, zablokuje enz\u00fdm, ktor\u00fd aldoster\u00f3n vyr\u00e1ba. Liek tak \u201ezavrie koh\u00fatik\u201c e\u0161te predt\u00fdm, ne\u017e sa probl\u00e9m rozbehne. Pr\u00e1ve tento pr\u00edstup vedci pova\u017euj\u00fa za k\u013e\u00fa\u010dov\u00fd rozdiel.<\/p>\n

Aldoster\u00f3n toti\u017e riadi, ko\u013eko soli a vody si telo zadr\u017e\u00ed. Ak ho telo produkuje pr\u00edli\u0161 ve\u013ea, objem krvi rastie a tlak st\u00fapa. Tento mechanizmus hr\u00e1 ve\u013ek\u00fa rolu najm\u00e4 u \u013eud\u00ed, ktor\u00ed konzumuj\u00fa ve\u013ea soli. To\u00a0je dnes be\u017en\u00e9 takmer v\u0161ade, od polotovarov a\u017e po fast food.<\/p>\n

Pr\u00e1ve preto m\u00f4\u017ee ma\u0165 baxdrostat \u0161ir\u0161\u00ed v\u00fdznam. Necieli len na jednotliv\u00fd probl\u00e9m, ale na jeden z hlavn\u00fdch \u201eciviliza\u010dn\u00fdch\u201c faktorov vysok\u00e9ho tlaku<\/a>.<\/p>\n

V\u00fdvoj tak\u00e9hoto lieku v\u0161ak nebol jednoduch\u00fd. Enz\u00fdm, ktor\u00fd vytv\u00e1ra aldoster\u00f3n, je ve\u013emi podobn\u00fd enz\u00fdmu zodpovedn\u00e9mu za tvorbu kortizolu, horm\u00f3nu, ktor\u00fd telo potrebuje na zvl\u00e1danie stresu. Star\u0161ie pokusy zasiahli oba naraz, \u010do sp\u00f4sobovalo nebezpe\u010dn\u00e9 ved\u013eaj\u0161ie \u00fa\u010dinky.<\/p>\n

\"srdce\"srdceZdroj: Patrick J. Lynch, medical illustrator (CC BY 2.5)<\/p>\n

Baxdrostat priniesol rie\u0161enie. Dok\u00e1\u017ee rozl\u00ed\u0161i\u0165 medzi t\u00fdmito dvoma enz\u00fdmami a zasiahne len ten spr\u00e1vny. Pr\u00e1ve t\u00e1to presnos\u0165 umo\u017enila vedcom posun\u00fa\u0165 v\u00fdvoj \u010falej.<\/p>\n

\u201eTieto v\u00fdsledky predstavuj\u00fa d\u00f4le\u017eit\u00fd krok v lie\u010dbe a z\u00e1rove\u0148 menia na\u0161e ch\u00e1panie pr\u00ed\u010din \u0165a\u017eko kontrolovate\u013en\u00e9ho tlaku,\u201c uviedol Williams.<\/p>\n

\u00da\u010dinok lieku navy\u0161e pretrval aj pri dlh\u0161om sledovan\u00ed. Pacienti si udr\u017eali ni\u017e\u0161\u00ed tlak a\u017e 32 t\u00fd\u017ed\u0148ov a v\u00fdskum neodhalil \u017eiadne ne\u010dakan\u00e9 bezpe\u010dnostn\u00e9 probl\u00e9my. To nazna\u010duje, \u017ee liek m\u00e1 potenci\u00e1l aj pri dlhodobom pou\u017e\u00edvan\u00ed.<\/p>\n

Probl\u00e9m vysok\u00e9ho tlaku sa dnes \u010doraz viac pres\u00fava mimo z\u00e1padn\u00e9ho sveta. Najviac pacientov \u017eije v \u00c1zii a rozvojov\u00fdch krajin\u00e1ch, kde sa men\u00ed strava aj \u017eivotn\u00fd \u0161t\u00fdl. Aj preto vedci odhaduj\u00fa, \u017ee podobn\u00fd typ lie\u010dby by mohol pom\u00f4c\u0165 stovk\u00e1m mili\u00f3nov \u013eud\u00ed.<\/p>\n

\u201eTento liek by mohol pom\u00f4c\u0165 a\u017e pol miliarde \u013eud\u00ed na svete,\u201c dodal Williams.<\/p>\n

Zatia\u013e v\u0161ak ide o v\u00fdsledky klinickej \u0161t\u00fadie. Liek \u010dakaj\u00fa \u010fal\u0161ie kroky, k\u00fdm sa dostane do be\u017enej praxe. Napriek tomu u\u017e teraz ukazuje, \u017ee aj pri tak roz\u0161\u00edrenom probl\u00e9me existuje priestor na nov\u00e9 rie\u0161enia, ktor\u00e9 zasiahnu priamo jeho pr\u00ed\u010dinu.<\/p>\n


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<\/p>\n","protected":false},"excerpt":{"rendered":"Vysok\u00fd krvn\u00fd tlak patr\u00ed medzi najroz\u0161\u00edrenej\u0161ie zdravotn\u00e9 probl\u00e9my dne\u0161ka. Postihuje pribli\u017ene 1,3 miliardy \u013eud\u00ed a u ve\u013ekej \u010dasti…\n","protected":false},"author":2,"featured_media":10324,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[32],"tags":[16900,34,37,13531,16901,4524,3500,16902,16903,33,2131,10330,43,40,39,42,41,36,7993,38,35,13650,16904],"class_list":{"0":"post-38757","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-spravy","8":"tag-baxdrostat","9":"tag-headlines","10":"tag-hlavne-spravy","11":"tag-infarkt","12":"tag-klinicke-testy","13":"tag-liecba","14":"tag-liek","15":"tag-lieky-na-vysoky-tlak","16":"tag-mrtvica","17":"tag-news","18":"tag-pacienti","19":"tag-riziko","20":"tag-sk","21":"tag-slovak","22":"tag-slovakia","23":"tag-slovencina","24":"tag-slovensko","25":"tag-spravy","26":"tag-testovanie","27":"tag-titulky","28":"tag-top-stories","29":"tag-ucinok","30":"tag-vysoky-tlak"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@sk\/116365386262596196","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/posts\/38757","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/comments?post=38757"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/posts\/38757\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/media\/10324"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/media?parent=38757"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/categories?post=38757"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/tags?post=38757"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}