\u010cL\u00c1NOK POKRA\u010cUJE POD REKLAMOU<\/p>\n
Vedci hl\u00e1sia prelom, ktor\u00fd m\u00f4\u017ee z\u00e1sadne zmeni\u0165 lie\u010dbu nielen rakoviny, ale aj autoimunitn\u00fdch ochoren\u00ed. Ako informuje port\u00e1l IFL SCIENCE<\/a>, terapia zn\u00e1ma ako CAR-T priniesla mimoriadne v\u00fdsledky<\/a> u pacientky trpiacej viacer\u00fdmi v\u00e1\u017enymi diagn\u00f3zami.<\/p>\n Ide o modern\u00fa bunkov\u00fa lie\u010dbu, pri ktorej sa vyu\u017e\u00edvaj\u00fa vlastn\u00e9 imunitn\u00e9 bunky pacienta. Tie vedci upravia tak, aby dok\u00e1zali cielene ni\u010di\u0165 \u0161kodliv\u00e9 bunky v tele.<\/p>\n Tento pr\u00edstup sa u\u017e nieko\u013eko rokov vyu\u017e\u00edva najm\u00e4 pri niektor\u00fdch typoch rakoviny krvi, kde prin\u00e1\u0161a ve\u013emi s\u013eubn\u00e9 v\u00fdsledky.<\/p>\n Vedci objavili mo\u017en\u00fa lie\u010dbu<\/p>\n Najnov\u0161ie sa v\u0161ak ukazuje, \u017ee by tento pr\u00edstup mohol fungova\u0165 aj pri autoimunitn\u00fdch ochoreniach. V konkr\u00e9tnom pr\u00edpade i\u0161lo o 47-ro\u010dn\u00fa pacientku, ktor\u00e1 viac ne\u017e desa\u0165 rokov trpela tromi v\u00e1\u017enymi chorobami, a to konkr\u00e9tne autoimunitnou hemolytickou an\u00e9miou, imunitnou trombocytop\u00e9niou a antifosfolipidov\u00fdm syndr\u00f3mom.<\/p>\n Ka\u017ed\u00e9 z t\u00fdchto ochoren\u00ed zasahuje organizmus in\u00fdm sp\u00f4sobom, no spolo\u010dn\u00fdm probl\u00e9mom je, \u017ee imunitn\u00fd syst\u00e9m nap\u00e1da vlastn\u00e9 telo.<\/p>\n Pacientka absolvovala mno\u017estvo lie\u010debn\u00fdch postupov vr\u00e1tane imunosupres\u00edv, steroidov \u010di biologickej lie\u010dby. Napriek tomu sa jej stav nezlep\u0161oval. Lek\u00e1ri preto prist\u00fapili k experiment\u00e1lnej mo\u017enosti \u2013 CAR-T terapii.<\/p>\n \u010co je to CAR-T terapia?<\/p>\n Proces lie\u010dby spo\u010d\u00edva v odobrat\u00ed T-lymfocytov z krvi pacienta, ktor\u00e9 s\u00fa n\u00e1sledne geneticky upraven\u00e9. Tieto upraven\u00e9 bunky dok\u00e1\u017eu rozpozna\u0165 konkr\u00e9tny cie\u013e. V tomto pr\u00edpade i\u0161lo o B bunky, ktor\u00e9 zohr\u00e1vali k\u013e\u00fa\u010dov\u00fa \u00falohu pri vzniku ochoren\u00ed. Po ich namno\u017een\u00ed v laborat\u00f3riu sa vr\u00e1tia sp\u00e4\u0165 do tela pacienta, kde za\u010dn\u00fa p\u00f4sobi\u0165.<\/p>\n V\u00fdsledok prekvapil aj samotn\u00fdch vedcov. Lie\u010dba dok\u00e1zala odstr\u00e1ni\u0165 v\u0161etky tri ochorenia naraz. Pacientka u\u017e nepotrebuje transf\u00fazie krvi, jej krvn\u00e9 hodnoty sa stabilizovali a riziko zr\u00e1\u017eania krvi v\u00fdrazne kleslo.<\/p>\n \u201eLie\u010dba bola mimoriadne \u00fa\u010dinn\u00e1 pri odstr\u00e1nen\u00ed v\u0161etk\u00fdch troch autoimunitn\u00fdch ochoren\u00ed naraz. Po viac ako desa\u0165ro\u010d\u00ed choroby je pacientka teraz v remisii bez potreby lie\u010dby a m\u00f4\u017ee sa vr\u00e1ti\u0165 k takmer norm\u00e1lnemu \u017eivotu,\u201c uviedol vedec Fabian M\u00fcller.<\/p>\n \u201eResetovali\u201c jej imunitn\u00fd syst\u00e9m<\/p>\n Pod\u013ea jeho slov terapia v podstate \u201eresetovala\u201c imunitn\u00fd syst\u00e9m pacientky. Organizmus si n\u00e1sledne vytvoril nov\u00e9 bunky, ktor\u00e9 u\u017e nevykazovali patologick\u00e9 spr\u00e1vanie. \u201eR\u00fdchlos\u0165 a h\u013abka reakcie boli pozoruhodn\u00e9,\u201c dodal M\u00fcller.<\/p>\n Aj po roku od lie\u010dby zost\u00e1va pacientka bez potreby \u010fal\u0161ej terapie. Vedci v\u0161ak upozor\u0148uj\u00fa, \u017ee ide zatia\u013e len o jeden pr\u00edpad. Na potvrdenie \u00fa\u010dinnosti tejto met\u00f3dy pri autoimunitn\u00fdch ochoreniach bude potrebn\u00fd \u010fal\u0161\u00ed v\u00fdskum a klinick\u00e9 \u0161t\u00fadie.<\/p>\n Vyu\u017e\u00edvaj\u00fa ju aj na Slovensku<\/p>\n Ako sme \u0165a u\u017e informovali<\/a> v roku 2024, t\u00e1to revolu\u010dn\u00e1 lie\u010dba sa vyu\u017e\u00edva aj na Slovensku. V N\u00e1rodnom onkologickom \u00fastave v Bratislave ju za\u010dali aplikova\u0165 pri viacer\u00fdch diagn\u00f3zach rakoviny krvi a lymfatick\u00e9ho syst\u00e9mu. CAR-T bunky sa pritom upravuj\u00fa v laborat\u00f3riu tak, aby dok\u00e1zali rozpozna\u0165 a zni\u010di\u0165 n\u00e1dorov\u00e9 bunky.<\/p>\n Lek\u00e1ri vtedy upozor\u0148ovali, \u017ee ide o n\u00e1dej najm\u00e4 pre pacientov, ktor\u00ed vy\u010derpali v\u0161etky \u0161tandardn\u00e9 mo\u017enosti lie\u010dby. V niektor\u00fdch pr\u00edpadoch dok\u00e1\u017ee t\u00e1to terapia vylie\u010di\u0165 pribli\u017ene troch a\u017e \u0161tyroch pacientov z desiatich, \u010do je pri \u0165a\u017ek\u00fdch form\u00e1ch rakoviny v\u00fdznamn\u00fd posun.<\/p>\n Proces lie\u010dby je pomerne komplexn\u00fd. Pacientovi odober\u00fa biele krvinky \u2013 konkr\u00e9tne T-lymfocyty \u2013 ktor\u00e9 sa n\u00e1sledne geneticky upravia v \u0161pecializovanom laborat\u00f3riu. Do buniek sa vlo\u017e\u00ed g\u00e9n, v\u010faka ktor\u00e9mu dok\u00e1\u017eu rozpozna\u0165 nebezpe\u010dn\u00e9 bunky v tele. Po ich namno\u017een\u00ed sa vracaj\u00fa sp\u00e4\u0165 pacientovi vo forme inf\u00fazie. Tieto upraven\u00e9 bunky potom v tele p\u00f4sobia ako \u201e\u017eiv\u00fd liek\u201c a m\u00f4\u017eu pre\u017e\u00edva\u0165 aj nieko\u013eko rokov.<\/p>\n \n \u010c\u00edtaj viac z kateg\u00f3rie: Zauj\u00edmavosti<\/a>\n <\/p>\n \n \u010eakujeme, \u017ee \u010d\u00edta\u0161 Startitup. V pr\u00edpade, \u017ee m\u00e1\u0161 postreh alebo si na\u0161iel v \u010dl\u00e1nku chybu, nap\u00ed\u0161 n\u00e1m na redakcia@startitup.sk<\/a>.\n <\/p>\n Zdroje: IFL\u00a0SCIENCE<\/a>, Redakcia\u00a0Startitup<\/a>, eurekalert.org<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"\u010cL\u00c1NOK POKRA\u010cUJE POD REKLAMOU Vedci hl\u00e1sia prelom, ktor\u00fd m\u00f4\u017ee z\u00e1sadne zmeni\u0165 lie\u010dbu nielen rakoviny, ale aj autoimunitn\u00fdch ochoren\u00ed.…\n","protected":false},"author":2,"featured_media":42683,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[18158,18159,4524,1629,43,40,44,39,42,45,41],"class_list":{"0":"post-42682","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-slovensko","8":"tag-autoimunitne-ochorenia","9":"tag-car-t","10":"tag-liecba","11":"tag-rakovina","12":"tag-sk","13":"tag-slovak","14":"tag-slovak-republic","15":"tag-slovakia","16":"tag-slovencina","17":"tag-slovenska-republika","18":"tag-slovensko"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@sk\/116393147323103600","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/posts\/42682","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/comments?post=42682"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/posts\/42682\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/media\/42683"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/media?parent=42682"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/categories?post=42682"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/tags?post=42682"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}