\u010cL\u00c1NOK POKRA\u010cUJE POD REKLAMOU<\/p>\n
Tvoje telo ti ka\u017ed\u00fd de\u0148 posiela spr\u00e1vy o tvojom zdravotnom stave priamo do tvojho krvn\u00e9ho obehu. O tom, \u017ee vedci z Kalifornskej univerzity v Los Angeles (UCLA) tento proces pr\u00e1ve de\u0161ifrovali, informoval web UCLA<\/a>.<\/p>\n Vyvinuli toti\u017e prelomov\u00fd, finan\u010dne nen\u00e1ro\u010dn\u00fd krvn\u00fd test, ktor\u00fd v r\u00e1mci prvotn\u00fdch \u0161t\u00fadi\u00ed preuk\u00e1zal schopnos\u0165 identifikova\u0165 nielen viacer\u00e9 typy onkologick\u00fdch ochoren\u00ed<\/a>, ale s\u00fa\u010dasne aj r\u00f4zne stavy pe\u010dene \u010di anom\u00e1lie in\u00fdch org\u00e1nov. Tento n\u00e1stroj by mohol znamena\u0165 z\u00e1sadn\u00fd posun k dostupnej\u0161iemu monitorovaniu tvojho zdravia.<\/p>\n DNA ako zrkadlo tvojich org\u00e1nov<\/p>\n Z\u00e1kladom tejto inov\u00e1cie je met\u00f3da nazvan\u00e1 MethylScan. Funguje na princ\u00edpe anal\u00fdzy takzvanej bezbunkovej DNA (cfDNA), \u010do s\u00fa drobn\u00e9 \u00falomky genetick\u00e9ho materi\u00e1lu, ktor\u00e9 sa uvo\u013e\u0148uj\u00fa do tvojej krvi, ke\u010f bunky v tele odumieraj\u00fa.<\/p>\n Ako vysvet\u013euje profesorka Jasmine Zhou, denne v tvojom tele zanikne 50 a\u017e 70 mili\u00e1rd buniek, ktor\u00e9 sa len tak nevyparia, ale zanechaj\u00fa svoju stopu v krvi. Ke\u010f\u017ee DNA uvo\u013e\u0148uje ka\u017ed\u00fd org\u00e1n, cfDNA v sebe nesie molekul\u00e1rne sign\u00e1ly o tom, \u010do sa pr\u00e1ve deje v tvojich p\u013e\u00facach, pe\u010deni \u010di \u017eal\u00fadku.<\/p>\n Ak sa podar\u00ed zachyti\u0165 rakovinu v prvom \u0161t\u00e1diu, vyhliadky na \u00faspe\u0161n\u00fa lie\u010dbu s\u00fa pod\u013ea doktorky Zhou neporovnate\u013ene lep\u0161ie, ne\u017e ke\u010f sa na \u0148u pr\u00edde a\u017e v \u0161t\u00e1diu \u0161tvrtom.<\/p>\n Inteligentn\u00e9 rie\u0161enie proti digit\u00e1lnemu \u0161umu<\/p>\n Hoci my\u0161lienka tekutej biopsie nie je \u00faplne nov\u00e1, doteraj\u0161ie testy sa \u010dasto zameriavali na drah\u00e9 h\u013eadanie mut\u00e1ci\u00ed v n\u00e1dorovej DNA. T\u00edm z UCLA sa v\u0161ak namiesto mut\u00e1ci\u00ed s\u00fastredil na chemick\u00e9 zna\u010dky, zn\u00e1me ako metyl\u00e1cia DNA, ktor\u00e9 reguluj\u00fa aktivitu g\u00e9nov. \u201eMetyl\u00e1cia DNA odr\u00e1\u017ea zdravotn\u00fd stav tkaniva,\u201c hovor\u00ed Dr. Wenyuan Li.<\/p>\n Najv\u00e4\u010d\u0161ou v\u00fdzvou bolo, \u017ee a\u017e 90 % DNA v tvojej krvi poch\u00e1dza z be\u017en\u00fdch krviniek, \u010do vytv\u00e1ra obrovsk\u00fd \u201e\u0161um\u201c. Vedci preto vyvinuli techniku, ktor\u00e1 pomocou \u0161peci\u00e1lnych enz\u00fdmov tento balast odstr\u00e1ni e\u0161te pred samotn\u00fdm sekvenovan\u00edm. V\u010faka tomu dok\u00e1\u017eu drasticky zn\u00ed\u017ei\u0165 n\u00e1klady \u2013 spracovanie vzorky by pri optim\u00e1lnych podmienkach mohlo st\u00e1\u0165 menej ako 20 dol\u00e1rov.<\/p>\n Presnos\u0165, ktor\u00e1 ti m\u00f4\u017ee zachr\u00e1ni\u0165 \u017eivot<\/p>\n Pri testovan\u00ed na vzork\u00e1ch od 1 061 \u013eud\u00ed MethylScan spr\u00e1vne identifikoval pribli\u017ene 63 % onkologick\u00fdch ochoren\u00ed<\/a> vo v\u0161etk\u00fdch \u0161t\u00e1di\u00e1ch a 55 % v t\u00fdch v\u010dasn\u00fdch. E\u0161te lep\u0161ie v\u00fdsledky dosiahol pri sledovan\u00ed rizikov\u00fdch pacientov s rakovinou pe\u010dene, kde zachytil takmer 80 % pr\u00edpadov.<\/p>\n Test navy\u0161e funguje ako tvoj osobn\u00fd zdravotn\u00fd radar \u2013 dok\u00e1\u017ee presne ur\u010di\u0165, z ktor\u00e9ho org\u00e1nu podozriv\u00fd sign\u00e1l poch\u00e1dza. Taktie\u017e dok\u00e1zal s 85 % \u00faspe\u0161nos\u0165ou rozl\u00ed\u0161i\u0165 medzi r\u00f4znymi typmi po\u0161kodenia pe\u010dene, \u010d\u00edm by ti v bud\u00facnosti mohol u\u0161etri\u0165 bolestiv\u00fa invaz\u00edvnu biopsiu.<\/p>\n Hoci n\u00e1s e\u0161te \u010dakaj\u00fa rozsiahlej\u0161ie testy, tento pokrok n\u00e1s v\u00fdrazne pribli\u017euje k univerz\u00e1lnemu testu na detekciu \u0161irok\u00e9ho spektra chor\u00f4b.<\/p>\n Chemick\u00fd odtla\u010dok rakovinovej bunky<\/p>\n Zatia\u013e \u010do kalifornsk\u00fd v\u00fdskum sa s\u00fastred\u00ed na chemick\u00e9 zna\u010dky v DNA, in\u00fd vedeck\u00fd t\u00edm h\u013ead\u00e1 odpovede v samotnom svetle. U\u017e v minulosti sme \u0165a informovali<\/a> o snah\u00e1ch diagnostikova\u0165 rakovinu z krvi, no britsk\u00ed odborn\u00edci posunuli hranicu mo\u017en\u00e9ho a\u017e na \u00farove\u0148 jedinej bunky.<\/p>\n Tento pr\u00edstup sa nes\u00fastre\u010fuje na genetick\u00fd k\u00f3d, ale na unik\u00e1tny \u201epodpis\u201c, ktor\u00fd po sebe zanech\u00e1vaj\u00fa rakovinov\u00e9 bunky putuj\u00face tvoj\u00edm telom.<\/p>\n Britsk\u00ed vedci z Loughborough University a ich partneri vyvinuli met\u00f3du, ktor\u00e1 vyu\u017e\u00edva infra\u010derven\u00e9 svetlo na anal\u00fdzu tvojej krvi. T\u00e1to technol\u00f3gia, odborne naz\u00fdvan\u00e1 FT-IR mikrospektroskopia, dok\u00e1\u017ee identifikova\u0165 jedin\u00fa rakovinov\u00fa bunku medzi mili\u00f3nmi zdrav\u00fdch krviniek.<\/p>\n Princ\u00edp je v podstate prost\u00fd \u2013 svetlo prech\u00e1dza bunkou a l\u00e1tky v nej ho absorbuj\u00fa unik\u00e1tnym sp\u00f4sobom, \u010d\u00edm vznik\u00e1 jej \u0161pecifick\u00fd chemick\u00fd odtla\u010dok. Tento odtla\u010dok prezrad\u00ed pr\u00edtomnos\u0165 cirkuluj\u00facich n\u00e1dorov\u00fdch buniek (CTC), ktor\u00e9 signalizuj\u00fa \u0161\u00edrenie choroby sk\u00f4r, ne\u017e by si si nie\u010do v\u0161imol.<\/p>\n V\u00fdhoda ukryt\u00e1 v chemickom zlo\u017een\u00ed<\/p>\n Star\u0161ie met\u00f3dy \u010dasto zlyh\u00e1vali, preto\u017ee rakovinov\u00e9 bunky s\u00fa majstrami v maskovan\u00ed a neust\u00e1le menia svoj tvar. Nov\u00fd test v\u0161ak toto maskovanie obch\u00e1dza, preto\u017ee sa nepozer\u00e1 na to, ako bunka vyzer\u00e1 navonok, ale na jej chemick\u00e9 vn\u00fatro.<\/p>\n Pr\u00edprava je pre tvoje pohodlie ve\u013emi nen\u00e1ro\u010dn\u00e1 \u2013 tvoja vzorka krvi sa jednoducho polo\u017e\u00ed na skl\u00ed\u010dko a nasvieti infra\u010derven\u00fdm l\u00fa\u010dom. Cel\u00fd proces je r\u00fdchly a cenovo dostupn\u00fd, \u010do znamen\u00e1, \u017ee by ho v doh\u013eadnej dobe mohlo zvl\u00e1da\u0165 ka\u017ed\u00e9 be\u017en\u00e9 nemocni\u010dn\u00e9 laborat\u00f3rium bez potreby extr\u00e9mne drah\u00e9ho vybavenia.<\/p>\n Bud\u00facnos\u0165 bez invaz\u00edvnych z\u00e1krokov<\/p>\n Cie\u013eom profesorov, ako je Paul Roach, je vytvori\u0165 plne automatizovan\u00fd syst\u00e9m, ktor\u00fd by sa stal be\u017enou s\u00fa\u010das\u0165ou zdravotnej starostlivosti. Tento test by mohol z\u00e1sadne ur\u00fdchli\u0165 odhalenie rakoviny p\u013e\u00fac a nesk\u00f4r aj in\u00fdch druhov onkologick\u00fdch ochoren\u00ed bez toho, aby si musel podstupova\u0165 bolestiv\u00e9 biopsie.<\/p>\n Moment\u00e1lne vedci h\u013eadaj\u00fa partnerov na \u010fal\u0161ie zdokona\u013eovanie technol\u00f3gie a testovanie na v\u00e4\u010d\u0161\u00edch skupin\u00e1ch pacientov. Ak sa v\u0161etko potvrd\u00ed, oby\u010dajn\u00fd odber krvi u lek\u00e1ra ti \u010doskoro poskytne tak\u00fa h\u013abkov\u00fa anal\u00fdzu tvojho zdravia, o akej sme pred p\u00e1r rokmi len sn\u00edvali.<\/p>\n \n \u010c\u00edtaj viac z kateg\u00f3rie: Wellbeing<\/a>\n <\/p>\n \n \u010eakujeme, \u017ee \u010d\u00edta\u0161 Startitup. V pr\u00edpade, \u017ee m\u00e1\u0161 postreh alebo si na\u0161iel v \u010dl\u00e1nku chybu, nap\u00ed\u0161 n\u00e1m na redakcia@startitup.sk<\/a>.\n <\/p>\n Zdroje: newsroom.ucla.edu<\/a>, startitup.sk<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"\u010cL\u00c1NOK POKRA\u010cUJE POD REKLAMOU Tvoje telo ti ka\u017ed\u00fd de\u0148 posiela spr\u00e1vy o tvojom zdravotnom stave priamo do tvojho…\n","protected":false},"author":2,"featured_media":59637,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[33,23619,1629,43,40,42,36,50,23620,49,48],"class_list":{"0":"post-59636","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-svet","8":"tag-news","9":"tag-novy-krvny-test-na-rakovinu","10":"tag-rakovina","11":"tag-sk","12":"tag-slovak","13":"tag-slovencina","14":"tag-spravy","15":"tag-svet","16":"tag-vedecky-objav","17":"tag-world","18":"tag-world-news"},"share_on_mastodon":{"url":"https:\/\/pubeurope.com\/@sk\/116507140628749205","error":""},"_links":{"self":[{"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/posts\/59636","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/comments?post=59636"}],"version-history":[{"count":0,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/posts\/59636\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/media\/59637"}],"wp:attachment":[{"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/media?parent=59636"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/categories?post=59636"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.europesays.com\/sk\/wp-json\/wp\/v2\/tags?post=59636"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}