![\"Thryv](\"https:\/\/s.yimg.com\/lo\/mysterio\/api\/844820ea068752d37f1c8d4f35ebe3c881ed5b3a981cdc8f40e8c7c104206f52\/lightyear_networkapi\/resizefit_w960%3Bquality_80%3Bformat_webp\/https%3A%2F%2Fmedia.zenfs.com%2Fen%2Fprnewswire.com%2Fa9251fab1fd0e867f22443a7fe6ceecc.jpg\")
<\/a> Thryv Therapeutics Inc. Logo <\/p>\nA second chemical scaffold <\/p>\n
Thryv’s existing clinical SGK1 inhibitor candidates were built through independent medicinal chemistry on a single in-licensed scaffold, supported by a library of more than 500 synthesized analogs and a granted selection patent estate. The CSIC\/UAM series is a distinct chemotype arising from an entirely separate discovery program, a genuinely new starting point rather than an extension of the existing series. Adding a second independent series gives Thryv the ability to match chemistry to indication, continuing to optimize its current molecules for cardiac and cardiometabolic diseases while developing compounds designed from the outset to reach the brain. <\/p>\n
Opening the neurodegeneration opportunity <\/p>\n
The licensed invention was developed by research groups with complementary expertise directly relevant to that ambition: the medicinal chemistry group led by Dr. Ana Mart\u00ednez and Dr. Carmen Gil and the cardiovascular group led by Dr. Eduardo Oliver P\u00e9rez at CSIC’s Centro de Investigaciones Biol\u00f3gicas Margarita Salas, together with the neurobiology group led by Dr. Isabel Lastres-Becker at UAM’s Institute for Biomedical Research and the vascular pharmacology group led by Dr. Ana Briones Alonso at UAM’s Department of Pharmacology. <\/p>\n
Activated SGK1 sits at the intersection of several pathways central to neurodegeneration. Published work has implicated the kinase in tau phosphorylation, in the handling of misfolded and aggregating proteins, in neuroinflammatory signaling, and in FOXO- and NRF2-dependent cellular stress responses. This disease biology is directly relevant to Parkinson’s disease, Alzheimer’s disease and related tauopathies. <\/p>\n
“This is a genuinely exciting day for Thryv,” said Debra Odink, President and Chief Development Officer of Thryv Therapeutics. “We have spent years building conviction that SGK1 is one of the most underexploited targets in medicine, and we have proven we can turn that conviction into clinical assets. What this license gives us is a second, independent chemical foundation: new scaffolds, new molecules, and the ability to go after diseases our current chemistry was never designed to reach. Very few companies of our size get to expand their platform this decisively.” <\/p>\n
“The work coming out of CSIC and UAM is exceptional, and the teams behind it are among the best in Europe at this intersection of chemistry and neurobiology,” Odink added. “Parkinson’s and Alzheimer’s disease remain two of the hardest problems in drug development. We now have a credible, systematic way to bring SGK1 biology to bear on them, while our cardiac programs continue to move forward at full speed.” <\/p>\n
Continuing momentum across the portfolio <\/p>\n
Thryv’s lead asset, THRV-1268, is an orally available, selective SGK1 inhibitor currently being evaluated in the WAVE II study in patients with Long QT Syndrome Type 2, with ASPIRE-HF, a Phase 2a study in heart failure with reduced ejection fraction, planned to follow. The newly licensed series is expected to be developed in parallel, with initial characterization work beginning immediately and a first development candidate targeted for nomination in 2027. <\/p>\n
About Thryv Therapeutics <\/p>\n
Thryv Therapeutics Inc. is a clinical-stage biopharmaceutical company advancing a proprietary portfolio of selective SGK1 inhibitors. The company pursues mechanisms with strong genetic and clinical validation, beginning in inherited arrhythmia syndromes and heart failure, and now extending into neurodegenerative diseases. Thryv is headquartered in Montr\u00e9al, Qu\u00e9bec. For more information, please visit www.thryvtrx.com<\/a>. <\/p>\n