Illustration of a pill bottle with stars and a crescent moon on the label, with floating pills alongside it against a dark blue background.

For many people, taking the prescription sleeping pill zolpidem (Ambien) isn’t a rare occurrence; it’s a nightly routine, and the only way they feel they can fall asleep. But the reliance on zolpidem has serious risks. Now, a trend in prescribing has shifted toward an “off-label” (unapproved) use of another pill known for its ability to make people drowsy: a low dose of the antidepressant drug trazodone.