It comes as around 30 masked youths gathered close to Orchard Row shortly after 6pm.
Bricks, bottles and masonry have been thrown at police lines.
It’s the second night riot teams have been deployed in the city.
A PSNI spokesperson said: “Police are dealing with ongoing disorder in the Nailors Row area of Derry / Londonderry this evening, Tuesday 17th June.
“A number of missiles, including masonry and petrol bombs, have been thrown towards officers.
“We would ask motorists and pedestrians to avoid the area until further notice.”
Last night, officers came under attack after the same group of youths attempted to attack homes in the Fountain Estate.
Three officers were injured after police came under attack during the overnight disorder, an MLA has said.
Authorities were pelted with debris and fireworks shortly after 8pm, close to the city walls.
A crowd had gathered in the Orchard Row area of the city before police were attacked.
The gathering was organised over social media on Monday night.
It’s understood that several attempts were made to attack homes in the Fountain Estate before police intervened.
Videos posted to social media show crowds of youths shooting fireworks at officers in riot gear.
In an update this afternoon, police confirmed two arrests have been made.
A spokesperson added: “A second arrest has been made today, 17 June, by police in Derry/Londonderry in connection with disorder in the Nailors Row area of the city last night, 16 June.
“A 13-year-old boy was arrested on suspicion of riotous behaviour, and has since been released on bail to allow for further police enquiries to be conducted.”
More to follow
Police come under attack for a second night in Derry (Photo Belfast Telegraph)
News Catch Up – Tuesday 17th June