The appeal comes as the NHS warns that supplies of this rare blood type are at risk of running low.
According to NHS Blood and Transplant, there are currently 1,497 B negative donors in the region who are eligible to give blood right now, as enough time has passed since their last donation.
They are being urged to come forward due to a combination of a shrinking B negative donor base and recent high demand for B negative blood.
With only two per cent of the population having B negative blood, it is one of the rarest types.
Patients with the B negative blood type can only receive B negative or O negative blood, meaning that low B negative stocks can also place a higher demand on vital emergency supplies of O negative.
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Currently, the number of active B negative donors has reached one of the lowest points in recent years, following a loss of 1,000 donors since 2023.
Fewer than 20,000 people with B negative blood currently donate regularly.
NHS Blood and Transplant is contacting all B negative donors, asking them to book an appointment to donate at the earliest opportunity.
Use the GiveBlood app or go to blood.co.uk to arrange an appointment.
Existing B negative donors will be given priority access to appointments and are urged to call 0300 123 23 23 if they are struggling to find availability.
Those with B negative blood are also asked to encourage family members to register and book an appointment to donate, as they are 30 per cent more likely to have this blood type than the general population.
New donors who already know they are B negative can now add their blood type when they register, allowing them also to be prioritised.
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Gerry Gogarty, director of blood supply, said: “B negative donors are immensely important to our lifesaving work, but as one of the rarest blood types, it can be a challenge to always collect enough. Right now B negative stocks are at risk of running low.
“With a blood type this rare, just a slight rise in hospital demand or one or two patients suddenly requiring a high number of units can put significant extra pressure on supplies.”
He added: “We urgently need existing B negative donors to make an appointment to donate, and more people with this blood type to become regular donors and help secure the life-saving supply of blood to patients in the weeks, months and years ahead.
“If you are a B negative donor and can’t find an appointment at a session near you, please call us and we will do what we can to make one available for you.
“If you have never given blood before and believe you are B negative, please sign up and book an appointment today.”
Donating a unit of blood takes just an hour, and each donation can save up to three lives.