The route is one of the busiest roads in the city and a major access point to Manchester city centre
The road will become 30mph.
The speed limit on a major Greater Manchester road is being lowered to try and improve air quality and stop traffic jams.
Regent Road in Salford will change from 40mph to 30mph between Gloucester Street and the M602 roundabout.
Salford council said new signs will be installed soon to make drivers aware of the change.
The route is one of the busiest roads in the city and a major access point to Manchester city centre.
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Coun Mike McCusker, Salford council’s transport lead, said the move is part of a region-wide scheme.
“This is all part of the Greater Manchester Clean Air plan to address nitrogen dioxide exceedances on the roads, to improve the flow of traffic, reducing emissions from drivers speeding up and slowing down,” he said.
Regent Road is a busy area of Salford, surrounded by a number of businesses as well as homes in Ordsall.
Other measures are also being planned along the road to help keep cars moving during periods with heavy traffic.
Coun McCusker added: “We have recently consulted on putting in yellow box junction cameras on Regent Road to prevent blockages at major junctions and help keep traffic flowing.”
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A number of large developments are being planned around region road, which could see thousands of people moving to the area in future.
This includes plans for 3,300 homes at Regent Retail Park, and 800 at Riverside Retail Park where there is currently a McDonald’s, KFC, and Grosvenor Casino.
Work is also taking place on roads in other parts of Salford, including a revamp of Chapel Street to make improvements for active travel such as walking and cycling.
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