A hearse and accompanying vehicles will slowly make their way down Broad Street from about 13:00 (12:00 GMT).
The procession will travel to the Black Sabbath Bridge and bench, where thousands of fans have left heartfelt messages and floral tributes.
The cortege will be accompanied by a live performance from Birmingham-based Bostin’ Brass Band and other local musicians.
A tram, named after Osbourne, unveiled in 2016, will also be parked nearby outside Birmingham Library while the cortege moves through the city.
The city council said the event was expected to draw large crowds of fans gathering to say goodbye to the man who “helped shape the global heavy metal genre” and “proudly carried the spirit of Birmingham”.