HCJ’s head of access, Emily Hoban, said there had been a “notable decline” in patients from Jersey using the service.
She said the bus had provided “an excellent and valuable service” for Jersey patients but was costing “significantly more” than the £19 an average taxi ride was costing.
“The Daisy Bus operates on a scheduled timetable and outside these times taxis are provided for patients, which is an additional cost.
“The decision was made to discontinue the service following a review which found that it was not the best value for money.”
She said Jersey patients would not be affected by the end of the bus service as taxis would be booked and paid for by HCJ.
Patients from the Isle of Wight who had also used the buses, have described them as an “essential” service for anyone on the island undergoing cancer treatment on the mainland.
A joint statement from Wessex Cancer Support and NHS trusts earlier this week said support for travelling patients remained available through NHS schemes for those who met eligibility criteria.
They include the NHS Healthcare Travel Costs Scheme (HTCS) and access to Non-Emergency Patient Transport Services (NEPTS).