The concert, which is part of the 22-date And Another Bloody Greatest Hits Tour, will be held at Bristol Beacon on March 24.
This tour follows their successful 2024 The Ultimate Ultimate Tour and will take them to major cities across the UK.
The final performance will be at London’s Royal Albert Hall in July.
Fronted by co-founder Graham Gouldman, 10cc have become a mainstream concert headliner in recent years.
The band has sold out top venues in cities such as Stockholm, San Francisco and Sydney.
The upcoming tour will feature a hit-packed setlist, including anthems like Rubber Bullets, Donna, Art for Art’s Sake and Dreadlock Holiday.
Fans can also expect to hear I’m Not in Love, which was recently performed by Gouldman and co-founder Kevin Godley in a BBC Radio 2 Piano Room session.
Gouldman said: “The tour title is not an expression of exasperation, but a humorous nod to the fact we’re out doing it again.
“We’ve had the Ultimate Greatest Hits Tour, then the Ultimate Ultimate tour and couldn’t add a third.
“Our audiences know what to expect – hit after hit after hit, with a few variations.”
The band comprises Gouldman on bass and guitars, Rick Fenn on lead electric guitar, Paul Burgess on drums and keyboards, Keith Hayman on keyboards and guitar and Iain Hornal on guitar, mandolin and vocals.
Earlier this year, Gouldman was awarded an MBE for services to music in the King’s Birthday Honours List.
The tour will start in March and tickets are set to be available soon.
Tickets are available via the Ticket Line website.