While Pakistan captain Fatima Sana managed to break the stand, Bangladesh were within touching distance by then and went on to seal the win with composure.
In the first innings, an all-round bowling effort would help them secure firm footing in their opening contest.
Winning the toss and opting to bat first, Pakistan were put under the pump right from the get-go as Marufa Akter helped Bangladesh seize advantage with two prolific in-swinging deliveries in the powerplay, removing Omaima Sohail and Sidra Amin in her opening burst.
Nahida Akter then, added further pressure on Pakistan by claiming Muneeba Ali and Rameen Shamim (23), who was the highest run-getter for her side, inside two overs from her first spell.
Rabiya Khan then claimed the crucial wicket of Sidra Nawaz, trapping her plumb with half of the Pakistan side back in the hut.