Ryan Reynolds recalled a “profound” musing Conan O’Brien once told him about making people happy.

“He talks about people-pleasing and pleasers in Hollywood,” Reynolds, 48, said during an event for John Candy: I Like Me in Brooklyn on Wednesday, October 8, according to People. “And Bill Murray says it too. You just can’t — it doesn’t work.”

He continued, “And what I found really fascinating about that is … being a people-pleaser is, quite literally, antithetical to having a mental-health crisis or issue.”

According to the Deadpool star, people-pleasers tend to not “want to burden anyone with anything.”

“The only way out is to center yourself, and to the people-pleaser that’s [difficult],” Reynolds said. “So it’s a paradox that is fascinating to me.”

 <span class="wp-caption-text">JOHN ANGELILLO/UPI/Newscom/The Mega Agency</span>

JOHN ANGELILLO/UPI/Newscom/The Mega Agency

According to People, Reynolds previously opened up about his own struggles with people-pleasing and mental health during the Toronto Film Festival premiere of the John Candy documentary.

“They don’t coexist very well together at all … You never want to be a problem for anybody else,” he said, adding of the late Uncle Buck star, “I feel for that guy struggling through that for so long at a period where it was just starting to be acceptable to talk about it a little bit more.”

John Candy: I Like Me — which Reynolds co-produced — premieres on  Prime Video on October 10.

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