UK police say they have arrested two suspects after “a number of people” were taken to hospital after a stabbing on a train in Cambridgeshire, in England’s east, about 120 kilometres north of London.

“We are currently responding to an incident on a train to Huntingdon where multiple people have been stabbed,” British Transport Police said on X, adding that “two people have been arrested”.

Cambridgeshire police said a number of people had been taken to hospital after the incident. 

Police cars and ambulances rushing to the scene at Huntingdon Station

Police cars and ambulances rushing to the scene in Huntingdon, about 120km north of London. (AFP: Justin Tallis)

Officers responded to calls at 7:39pm on Saturday of reports that multiple people had been stabbed on a train.

Armed police were at the scene and the train was stopped at Huntingdon, a market town in east England.

British Prime Minister Sir Keir Starmer called it an “appalling incident” that was deeply concerning.

“My thoughts are with all those affected, and my thanks go to the emergency services for their response. Anyone in the area should follow the advice of the police,” he said in a post on X.

Train operator London North Eastern Railway (LNER) said all its railway lines had been closed while emergency services dealt with the incident at Huntingdon station.

LNER, which runs rail services along the east of England and Scotland, urged passengers not to travel, warning of “major disruption”.

A screengrab of police running up a train platform.

Multiple people were stabbed in the incident.  (Tiktok: @.qonquest)

Home Secretary Shabana Mahmood asked people to “avoid comment and speculation” at this stage.

“I am deeply saddened to hear about the stabbings in Huntingdon. My thoughts go out to all those affected,” she said in a post on X.

“I am receiving regular updates on the investigation.”

Cambridgeshire and Peterborough Mayor Paul Bristow said he had heard of “horrendous scenes” on the train.

ABC/AFP