Due to go ahead on March 26, the winner faces playing Bosnia or Wales in the deciding qualifying fixture.
The clash is expected to kick-off at around 7.45pm.
But how much of a bill can supporters expect to foot for a trip to the Green and White Army’s face off with the Azzurri?
For those seeking a direct flight to Bergamo’s Caravaggio International Airport, the most affordable flights would be from Belfast – but prices are subject to change.
A 9.25am flight the day of the match from Belfast International Airport would touch down shortly before 1pm in Bergamo with Ryanair.
The return flight would be at 10am the following day, totalling £413.
A departing flight at 5.35pm on March 25, the day before the match, currently costs £468 with a return flight at 10am on March 27.
However, there are a number of cheaper options available for passengers willing to stop for a layover in London.
British Airways are offering a March 25 flight from Belfast City Airport at 3.40pm, arriving at 5.05pm at Heathrow Airport, departing at 6.35pm and touching down in Milan Linate Airport.
Jamie Donley celebrates scoring for Northern Ireland against Luxembourg in a World Cup qualifier last month
News Catch Up – Thursday 4 December
The Italian airport is a 35-minute train ride from Bergamo. A return journey on March 27 will cost a total of £257 per person.
And for fans wanting to avoid an extra hotel bill, a flight from Dublin with Ryanair arrives at 3.05pm at Milan Malpensa Airport, a two-hour train ride from Bergamo, on the day of match.
The flight departs from Dublin at 11.35am and returns to Ireland the following day for a total of £316.
On March 25, a British Airways flight from Dublin departing at 10.20am arrives in Heathrow for a layover before jetting off for Milan Linate Airport.
While the airport is a two-hour train ride from Bergamo, it is one of the cheapest options available with a price tag of £229.
A return flight on March 27 is also included in the deal.
In terms of accommodation, B&Bs will offer the best value for money with some as low as £50. Meanwhile, Hotels in Bergamo range between £100 and £200.