Scott Cummings will also reach a personal milestone when he comes off the bench with the Scotland and British & Irish Lions second-rower set to reach 150 appearances for the club, a week on from putting pen to paper on a new contract.
An all-new front-row sees Johnny Matthews return from injury to start at hooker, packing down between Patrick Schickerling and Sam Talakai. The starting front-row from last weekend – Nathan McBeth, Gregor Hiddleston and Zander Fagerson – will look to make an impact off the bench.
Alex Samuel also makes his return to action following injury alongside Alex Craig in the second-row, the latter making his first start since last month’s visit to the Scarlets.
Angus Fraser is the only change to the back-row that started at Hampden Park last weekend, replacing the benched Rory Darge at openside.
“We were pleased to get the win at Hampden Park last weekend, but we know that it is only half time in terms of the wider 1872 Cup series,” said head coach Smith.
“Edinburgh will bring physicality in both attack and defence in front of a passionate home support, and we know they will throw everything at us on Saturday afternoon.
“We are also pleased to see Kyle reach his century, and for Scott to reach 150 appearances – they each give their all each time they run out onto the field for this club, and we congratulate them on reaching their respective landmarks. From a personal perspective, I’m proud to see both men reach their milestones, and I know they will lead from the front on Saturday afternoon.”
Glasgow Warriors (v Edinburgh @ Murrayfiled on Saturday, 3pm kick-off BST – live on Premier Sports): O Smith; K Steyn ©, S McDowall, S Tuipulotu, J Dobie; A Hastings, G Horne; P Schickerking, J Matthews, S Talakai, A Craig, A Samuel, M Fagerson, A Fraser, J Dempsey. Replacements: G Hiddleston, N McBeth, Z Fagerson, S Cummings, G Brown, R Darge, B Afshar, D Lancaster.
Unavailable for selection: Jamie Bhatti (calf), Euan Ferrie (ankle), Huw Jones (ankle), Josh McKay (hamstring), Kyle Rowe (knee), Charlie Savala (knee), Tavi Tuipulotu (knee)