BBC reporter Giles Taylor, who was at the scene on the A46 in Leicestershire, said snow overnight had left conditions on the route “treacherous”.
He added “at least five vehicles” had left the road, between Six Hills and Widmerpool, some of which were in ditches.
It comes as snow and ice are expected across the UK on Friday, as forecasters warn of a “prolonged spell of very cold weather” to start 2026.
Delays and cancellations to rail and air travel, disruption on the roads and power cuts are all expected as a result of the wintry conditions.
Yellow warnings for snow and ice came into force for large parts of England, Northern Ireland and Wales at midnight on Thursday, remaining until midday on Friday in England and Wales.
Earlier, across the region in Derbyshire, the A38 was closed after being impacted by snow and “a number of collisions”.