Neon chief Tom Quinn, YouTuber Markiplier and actress Sophia Bush are among the speakers lined up for the conference strand at SXSW London, the U.K. spinoff of the Austin, Texas festival.

The second edition of the event, which runs in the hip Shoreditch district of London from June 1 to 6, has 300 conference sessions on a wide variety of subjects spanning technology, business, health and culture.

Other speakers include Eldridge’s Todd Boehly, fashion designer Katharine Hamnett, Cindy Rose, CEO of WPP, Mia Bays, director of BFI Film Fund, Ben Cohen, co-founder of Ben & Jerry’s, singer-songwriter Mike Skinner of The Streets, Nadia Fall, artistic director of the Young Vic theater and Lars Rasmussen, co-founder of Google Maps.

Six key themes feature in the program:

AI as the New Power Structure
Discussions span from the infrastructure that underpins global economies to the algorithms influencing them, the festival says. “As AI systems scale, questions of sovereignty, control, and ultimately, accountability are becoming everyday concerns.” Sessions will explore “who holds authority over the technologies defining the digital era and assess who bears responsibility within the algorithmic age.”

Living Longer, Living Better
“As technology changes how we understand health and longevity, reshaping healthcare far beyond traditional clinical settings,” the festival says. It will “explore how AI and machine learning are compressing timelines for medical discovery and development, and examine the real-world challenges of translating AI-led breakthroughs into treatments and therapies.”

Culture Can Save Humanity
“Culture has always been one of society’s most powerful forces for progress,” the festival says. This theme will explore “the growing complacency in creative industries, the power of music and creative communities to mobilize audiences and drive social impact, the role of nightlife culture in shaping communities, and artists using music to support climate action.”

Society Rewired
“Societies are being forced to confront new questions about governance and accountability as misinformation and media influence shift the boundaries of free speech,” SXSW London says. It will explore “how the rules that once defined public discourse are now redundant and how we navigate this evolving landscape, including the role of activism and how leaders are pushing back against authoritarian trends to defend democratic values.”

Creativity in the Algorithmic Age
“Platforms increasingly determine how audiences discover information, meaning creators and marketers alike are adapting to a world shaped by algorithms,” the festival states. Sessions will explore “how attention has become one of the most valuable currencies, question whether traditional marketing models are becoming obsolete, and examine how creators are learning to design content within algorithmic systems.”

Futurism in Practice
“Frontier technologies are redefining how people interact with the world, as advances in robotics, extended reality and AI reshape human experience,” SXSW London says. This theme will “explore the technologies blurring the boundaries between physical and digital environments – simultaneously examining breakthroughs emerging from advanced research institutions, including ARIA and Google DeepMind.”

Katy Arnander, director of programming at SXSW London, says: “SXSW London is centered around the idea of convergence, bringing together voices – even unexpected pairings – in ways that rarely happen elsewhere. This year’s agenda takes that idea even further. From frontier technology and medical innovation to music, activism and the creator economy, the program strikes a strong balance between tension and harmony, ultimately cultivating a space for healthy debate. By providing a space for this collision of ideas, SXSW London is the place for any business leader, venture capitalist, or marketer to gain insights, discover innovative concepts, and expand their professional networks.”