Associate director Alex Walker will head up the practice, moving into Park Square premises in a bid to better support its Northern clients.
Fellow director Nick Gregory will also be based at the office, which is looking to focus on the education, healthcare, residential, and industrial sectors.
Currently, the firm is on site with new schools in the north east, having recently completed a purpose-built-student-accommodation scheme in Durham.
CPMG also has studios in Nottingham, London, Birmingham, as well as bases in China and India.
Walker said: “Although CPMG has been actively working in the north of England for many years, it’s a proud moment for me personally to be leading our new studio in Leeds after more than 15 years with the practice.
“We believe Leeds is the ideal base for us to realise our growth ambitions across Yorkshire and surrounding regions.
“As we have done with our other studios, we’re excited to establish relationships with industry leaders in the different sectors and create pathways for local talent to forge a career in the design and construction industry.
“The new Leeds studio provides an opportunity to bring CPMG’s strong culture to a new city and build on our network of clients and contacts across the public and private sectors.”
Gregory said: “All of our studios have opened when the necessary criteria have fallen into place, so that our growth and expansion remains sustainable.
“Leeds will become our latest hub and it will enable us to increase our presence in Northern markets.
“Alex and I are both from the Leeds area, so we will have no problems speaking the local language, but we plan to allow our design ethos and experience to do the talking for us.”