Wales have no injury concerns among their 23-player squad, with the utilisation of former captain Sophie Ingle likely to present Wilkinson with her biggest selection issue.
Ingle has declared herself fit to start in Lucerne, but having not played a competitive game in a over a year after anterior cruciate ligament surgery (ACL), her inclusion from the start would be a surprise.
“I think not playing any 90 minutes to go in 90 minutes would be a challenge, but she’s healthy and back fully with the squad. And that is for someone who had, obviously, an ACL,” Wilkinson said.
“She’s been so professional and so diligent and so focused to be here. And to have her healthy and available is a testament to the hard work that she’s invested. I am really happy to have her back healthy.”
Wales must come up with a solution to replacing teenage defender Mayzee Davies in defence as she misses the tournament having undergone ACL surgery.
Crystal Palace defender Josie Green could come into the side, while dropping Hayley Ladd back into defence is another option, with Wales expected to stick with three central defenders.
Netherlands boss Jonker confirmed his side have doubts over two of their main attacking threats.
Manchester City forward Vivianne Miedema is fit, but having been severely hampered by injuries in the past two years, might not be risked from the start as she chases her 100th international goal (she is currently on 99).
Wolfsburg forward Lineth Beerensteyn is also a doubt, having been unable to train since Netherlands arrived in Switzerland.
Jonker revealed in his pre-match press conference that he is yet to tell his players the starting XI for their Euro opener, whereas Wilkinson says she told her players “a few days ago.”