Llandyrnog United are the visitors to Holyhead Road where new boss Ryan Roberts will be hoping for better luck in the cup.
They went out of the Welsh Cup last Sunday after a penalty shoot-out exit at home to Kinmel Bay.
Brad Pearce is still suspended but Brandon Edwards, Josh Williams and Matthew Cooke all return.
Young defender Dylan Northall, who also missed last week’s game, faces a late fitness test while new signing from Overton, Nathan Tombs, will join his brother, Matt, in the squad.
Kinmel Bay are now eyeing up another Ardal North cup scalp as they host Corwen tomorrow.
Corwen will just want a repeat of last week’s efforts on the North Wales coast where they triumphed 3-1 at previous Welsh Cup winners Prestatyn Town.
Rhydymwyn, with Anthony Weaver back in the manager’s hot-seat, host Pwllheli while Ruabon Rovers’ first game of the season is a trip to Llanfair United, who were beaten 4-1 by in-form Penycae on Tuesday night.
Penycae host one of the ties of the round with Gareth Thomas’ Prestatyn Town the visitors to Afoneitha.
Penycae have netted 11 goals in their opening two games of the season with captain Zac Davies bagging four of them.
Prestatyn head into the game on the back of a 3-1 win at home to Mynydd Isa in the Ardal North West League on Wednesday night.
Isa captain Sam Wainwright gave his side an early lead but the hosts hit back with goals from Casey Faulkner, Rob Parry and substitute Rob Hughes.
Isa will be aiming to bounce back at Forden United tomorrow while FC Queens Park host a Penrhyndeudraeth outfit who were floored 5-1 at Broughton United in the Welsh Cup.
Ryan Kershaw impressed for Park on his debut, scoring one and setting up the other in a 3-0 victory over Mynydd Llandegai.
Hawarden Rangers and Holywell United aim to make home advantage count against Llannefydd and Llanfairpwll respectively.
Saltney Town and Broughton will be looking to do the same in their home ties against Llandudno Amateurs and Meliden.