The 16-year-old centre-back will initially link up with Chris Moore’s Under-18s squad as a first year scholar.
The capture of Moran is a real coup for Newcastle, with the young centre-back having made his debut for Liverpool’s Under-18s when he was just 15 in March, last year.
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Moran has also captained England at youth level and played six times at Under-15 level.
Steve Harper, Newcastle’s academy director, said: “Isaac joins us with a strong pedigree and a maturity beyond his years.
“The leadership qualities he has displayed to date speak volumes about his character, and we’re excited to help him continue developing both as a player and a person.
“He’s a driven individual who fits the values of our academy perfectly.”
“Isaac’s addition to the academy reflects the continued excellence of our recruitment team, whose efforts remain integral to our long-term strategy.”