The junction of Cross Arthurlie Street with Allan’s Corner Roundabout and the junctions of Kirkton Avenue, Blackwood Street and Gertrude Place with Kelburn Street will all be affected.
The closures will be in place from Thursday, October 9 to Thursday, October 30.
Resurfacing works will be taking place during this time.
The works will be carried out in phases to allow access through Main Street and Kelburn Street at all times, along with access to the car parks at Tesco and the Westbourne Centre.
Temporary traffic signals will be in place to control traffic through the site.
All vehicles will be subject to the restrictions except those associated with the works and emergency vehicles attending an incident.
For the Cross Arthurlie junction closure, the alternative route will be Cross Arthurlie Street, Carlibar Road, Glen Street, Church Road, Main Street and vice versa.
For the Kirkton Avenue junction closure, the alternative route will be Kirkton Avenue, Levern Crescent, Springhill Road, Ralston Road, Main Street, Kelburn Street and vice versa.
For the Blackwood Street/Gertrude Place junction closure, the alternative route will be Blackwood Street/Gertrude Place, Kerr Street, Barnes Street, Cogan Street, Cross Arthurlie Street, Carlibar Road, Glen Street, Church Road, Main Street and vice versa.