Emergency services were alerted to reports of an injured man at the site on Waverley Road shortly after about 9.15am on Friday.
The Scottish Ambulance Service (SAS) dispatched an ambulance, a trauma team and a special operations team to the scene, while the Scottish Fire and Rescue Service (SFRS) sent two fire appliances and two special appliances.
Police were also in attendance.
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A 36-year-old man was taken to Queen Elizabeth University Hospital in Glasgow, where his condition is described as “critical”.
Officers said an investigation is ongoing, and that the Health and Safety Executive has been informed.
Queen Elizabeth University Hospital in Glasgow
A police cordon was put in place around the scene following the incident, with the public being asked to avoid the area.
A Police Scotland spokesperson said: “Officers and emergency services were called to a demolition site on Waverley Road in Paisley on Friday, January 9, 2026 after a man was injured.
“The 36-year-old was taken to hospital where hospital staff describe his condition as critical.
“An investigation into the circumstances remains ongoing and the Health and Safety Executive have been informed.
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“A cordon remains in place and the public should avoid the area.”
A SAS spokesperson said: “We received a call today to attend an incident on Waverley Road in Paisley.
“We dispatched one ambulance, our trauma team and our special operations team to the scene.
“We transported one male patient to Queen Elizabeth University Hospital.”