Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations
Isogenic model for TP53 mutagenesis by CRISPR-HDR To assess the functional impact of TP53 variants in a controlled…
Human subcutaneous and visceral adipocyte atlases uncover classical and nonclassical adipocytes and depot-specific patterns
Human fat depot-specific adipocyte atlases To generate hSAT and hVAT depot-specific human adipocyte atlases, we performed single-nucleus RNA…
Should the EU ease regulation on new generation GMOs?
ADVERTISEMENT Few topics are as divisive and controversial as genetically modified organisms (GMOs). The same level of contention…
A Planned Economy in Modern Russia? It Didn’t Work Last Time and Won’t Work Today.
The Kremlin seems to be preparing to introduce state-mandated prices for food. Or at least some foodstuffs. Of…
Pesticides application rate maps in the European Union at a 250 m spatial resolution
Here, we detail the methodology employed to generate the high-resolution pesticide maps. Our work takes 2018 as the…
Unlocking Apple Texture: A Genetic Key to Firmness and Ripening
Newswise — Apple fruit quality depends heavily on traits such as firmness, flavor, and color, which are regulated…
Genetic insights into infertility from large-scale analyses
World Health Organization. Infertility Prevalence Estimates, 1990–2021 (WHO, 2023). Venkatesh, S. S. et al. Nat. Genet. https://doi.org/10.1038/s41588-025-02156-8 (2025).…
Oryza genome evolution through a tetraploid lens
Tanksley, S. D. & McCouch, S. R. Seed banks and molecular maps: unlocking genetic potential from the wild.…
Spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosis
Participants and samples The studies described here comply with ethical regulations as approved under local institutional review boards,…
Mutations in the small nuclear RNA gene RNU2-2 cause a severe neurodevelopmental disorder with prominent epilepsy
More than 4,000 genes have been established as etiological for a rare disease, of which only 69 are…