Pan-genome analysis reveals the evolution and diversity of Malus
The Malus evolutionary genomic landscape We sequenced accessions from 30 species, de novo assembled high-quality genomes and anchored…
Advances in single-cell DNA sequencing enable insights into human somatic mosaicism
Bizzotto, S. et al. Landmarks of human embryonic development inscribed in somatic mutations. Science 371, 1249–1253 (2021). Article …
Pan-genomic analysis highlights genes associated with agronomic traits and enhances genomics-assisted breeding in alfalfa
Annicchiarico, P., Barrett, B., Brummer, E. C., Julier, B. & Marshall, A. H. Achievements and challenges in improving…
Transcriptome-wide analysis of differential expression in perturbation atlases
Dixit, A. et al. Perturb-seq: dissecting molecular circuits with scalable single-cell RNA profiling of pooled genetic screens. Cell…
Germany and Europe lead digital innovation and AI with collaborative health data use at continental level
Bienzeisler et al.1 show how federated access to 7.9 million data sets representing 2 million patients enables the…
Making cell therapy accessible: challenges and opportunities
Crystal Mackall: There are numerous bottlenecks. First, manufacturing of autologous products requires complex logistics wherein the product moves…
Genetic regulation of gene expression across multiple tissues in chickens
Hillier, L. W. & Miller, W. Sequence and comparative analysis of the chicken genome provide unique perspectives on…
Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery
Ethics statement This study complies with all relevant ethical regulations and was conducted in accordance with the research…
Vascular Ehlers Danlos Syndrome and Chromosome 2q32 Microdeletion Syndrome
Glass I, Swindlehurst C, Aitken D, McCrea W, Boyd E. Interstitial deletion of the long arm of chromosome…
The landscape of N6-methyladenosine in localized primary prostate cancer
The m6A landscape of localized prostate cancer We quantified the epitranscriptomes of 162 primary localized prostate tumors using…